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UniProtKB/Swiss-Prot entry Q96RK0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CIC_HUMAN
Primary accession number Q96RK0
Secondary accession numbers Q7LGI1 Q9UEG5 Q9Y6T1
Integrated into Swiss-Prot on September 27, 2005
Sequence was last modified on October 17, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 59)
Name and origin of the protein
Protein name Protein capicua homolog
Synonyms None
Gene name
Name: CIC
Synonyms: KIAA0306
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, AND VARIANT GLY-982.
DOI=10.1016/S0169-328X(02)00439-4; PubMed=12393275 [NCBI, ExPASy, EBI, Israel, Japan]
Lee C.-J., Chan W.-I., Cheung M., Cheng Y.-C., Appleby V.J., Orme A.T., Scotting P.J.;
"CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons.";
Brain Res. Mol. Brain Res. 106:151-156(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02399; PubMed=15057824 [NCBI, ExPASy, EBI, Israel, Japan]
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 158-1608, AND VARIANT GLY-982.
TISSUE=Brain;
DOI=10.1093/dnares/4.2.141; PubMed=9205841 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.";
DNA Res. 4:141-150(1997).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1397 AND SER-1409, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
[5]
TISSUE SPECIFICITY, AND EXPRESSION IN MEDULLOBLASTOMA.
DOI=10.1007/s11060-004-4598-2; PubMed=15981098 [NCBI, ExPASy, EBI, Israel, Japan]
Lee C.-J., Chan W.-I., Scotting P.J.;
"CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas.";
J. Neurooncol. 73:101-108(2005).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279 AND SER-1462, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1373; SER-1378 AND SER-1382, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
[8]
VARIANTS [LARGE SCALE ANALYSIS] LYS-104 AND THR-652.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF363689; AAK73515.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC006486; AAD11988.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB002304; BAA20765.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_055940.3; -.
UniGene Hs.388236
3D structure databases
HSSP P35710; 1I11. [HSSP ENTRY / PDB]
ModBase Q96RK0.
Protein-protein interaction databases
IntAct Q96RK0; -.
PTM databases
PhosphoSite Q96RK0; -.
Organism-specific databases
H-InvDB HIX0015175; -.
HGNC HGNC:14214; CIC.
GenAtlas CIC.
PharmGKB PA26513; -.
GeneCards Q96RK0.
HUGE KIAA0306.
Gene expression databases
CleanEx HS_CIC; -.
GermOnline ENSG00000079432; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR000910; HMG_1/2_box.
Graphical view of domain structure.
Gene3D G3DSA:1.10.30.10; HMG-box; 1.
Pfam PF00505; HMG_box; 1.
Pfam graphical view of domain structure.
SMART SM00398; HMG; 1.
SMART graphical view of domain structure.
PROSITE PS50118; HMG_BOX_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q96RK0.
Genome annotation databases
Ensembl ENSG00000079432; Homo sapiens. [Contig view]
GeneID 23152; -.
KEGG hsa:23152; -.
NMPDR fig|9606.3.peg.16553; -.
Phylogenomic databases
HOGENOM Q96RK0; -.
HOVERGEN Q96RK0; -.
Other
LinkHub Q96RK0; -.
ProtoNet Q96RK0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Repressor; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1608  1608     Protein capicua homolog. PRO_0000048598
DNA_BIND   200    268  69     HMG box. 
REGION   28     46  19     Interaction with ATXN1 (By similarity). 
COMPBIAS   42    138  97     Pro-rich. 
COMPBIAS   508   1303  796     Pro-rich. 
COMPBIAS   1524   1601  78     Pro-rich. 
MOD_RES   279    279        Phosphoserine. 
MOD_RES   904    904        Phosphoserine (By similarity). 
MOD_RES   1291   1291        Phosphothreonine (By similarity). 
MOD_RES   1294   1294        Phosphoserine (By similarity). 
MOD_RES   1373   1373        Phosphoserine. 
MOD_RES   1378   1378        Phosphoserine. 
MOD_RES   1382   1382        Phosphoserine. 
MOD_RES   1397   1397        Phosphoserine. 
MOD_RES   1402   1402        Phosphoserine (By similarity). 
MOD_RES   1409   1409        Phosphoserine. 
MOD_RES   1462   1462        Phosphoserine. 
VARIANT   104    104  1     E -> K (in a breast cancer sample; somatic mutation). VAR_035936 
VARIANT   652    652  1     A -> T (in a breast cancer sample; somatic mutation). VAR_035937 
VARIANT   982    982  1     S -> G (in dbSNP:rs17339472 [NCBI]). VAR_028302 
Sequence information
Length: 1608 AA [This is the length of the unprocessed precursor] Molecular weight: 163820 Da [This is the MW of the unprocessed precursor] CRC64: 355603C8BD67244E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MYSAHRPLMP ASSAASRGLG MFVWTNVEPR SVAVFPWHSL VPFLAPSQPD PSVQPSEAQQ 

        70         80         90        100        110        120 
PASHPVASNQ SKEPAESAAV AHERPPGGTG SADPERPPGA TCPESPGPGP PHPLGVVESG 

       130        140        150        160        170        180 
KGPPPTTEEE ASGPPGEPRL DSETESDHDD AFLSIMSPEI QLPLPPGKRR TQSLSALPKE 

       190        200        210        220        230        240 
RDSSSEKDGR SPNKREKDHI RRPMNAFMIF SKRHRALVHQ RHPNQDNRTV SKILGEWWYA 

       250        260        270        280        290        300 
LGPKEKQKYH DLAFQVKEAH FKAHPDWKWC NKDRKKSSSE AKPTSLGLAG GHKETRERSM 

       310        320        330        340        350        360 
SETGTAAAPG VSSELLSVAA QTLLSSDTKA PGSSSCGAER LHTVGGPGSA RPRAFSHSGV 

       370        380        390        400        410        420 
HSLDGGEVDS QALQELTQMV SGPASYSGPK PSTQYGAPGP FAAPGEGGAL AATGRPPLLP 

       430        440        450        460        470        480 
TRASRSQRAA SEDMTSDEER MVICEEEGDD DVIADDGFGT TDIDLKCKER VTDSESGDSS 

       490        500        510        520        530        540 
GEDPEGNKGF GRKVFSPVIR SSFTHCRPPL DPEPPGPPDP PVAFGKGYGS APSSSASSPA 

       550        560        570        580        590        600 
SSSASAATSF SLGSGTFKAQ ESGQGSTAGP LRPPPPGAGG PATPSKATRF LPMDPATFRR 

       610        620        630        640        650        660 
KRPESVGGLE PPGPSVIAAP PSGGGNILQT LVLPPNKEEQ EGGGARVPSA PAPSLAYGAP 

       670        680        690        700        710        720 
AAPLSRPAAT MVTNVVRPVS STPVPIASKP FPTSGRAEAS PNDTAGARTE MGTGSRVPGG 

       730        740        750        760        770        780 
SPLGVSLVYS DKKSAAATSP APHLVAGPLL GTVGKAPATV TNLLVGTPGY GAPAPPAVQF 

       790        800        810        820        830        840 
IAQGAPGGGT TAGSGAGAGS GPNGPVPLGI LQPGALGKAG GITQVQYILP TLPQQLQVAP 

       850        860        870        880        890        900 
APAPAPGTKA AAPSGPAPTT SIRFTLPPGT STNGKVLAAT APTPGIPILQ SVPSAPPPKA 

       910        920        930        940        950        960 
QSVSPVQAPP PGGSAQLLPG KVLVPLAAPS MSVRGGGAGQ PLPLVSPPFS VPVQNGAQPP 

       970        980        990       1000       1010       1020 
SKIIQLTPVP VSTPSGLVPP LSPATLPGPT SQPQKVLLPS STRITYVQSA GGHALPLGTS 

      1030       1040       1050       1060       1070       1080 
PASSQAGTVT SYGPTSSVAL GFTSLGPSGP AFVQPLLSAG QAPLLAPGQV GVSPVPSPQL 

      1090       1100       1110       1120       1130       1140 
PPACAAPGGP VITAFYSGSP APTSSAPLAQ PSQAPPSLVY TVATSTTPPA ATILPKGPPA 

      1150       1160       1170       1180       1190       1200 
PATATPAPTS PFPSATAGSM TYSLVAPKAQ RPSPKAPQKV KAAIASIPVG SFEAGASGRP 

      1210       1220       1230       1240       1250       1260 
GPAPRQPLEP GPVREPTAPE SELEGQPTPP APPPLPETWT PTARSSPPLP PPAEERTSAK 

      1270       1280       1290       1300       1310       1320 
GPETMASKFP SSSSDWRVPG QGLENRGEPP TPPSPAPAPA VAPGGSSESS SGRAAGDTPE 

      1330       1340       1350       1360       1370       1380 
RKEAAGTGKK VKVRPPPLKK TFDSVDNRVL SEVDFEERFA ELPEFRPEEV LPSPTLQSLA 

      1390       1400       1410       1420       1430       1440 
TSPRAILGSY RKKRKNSTDL DSAPEDPTSP KRKMRRRSSC SSEPNTPKSA KCEGDIFTFD 

      1450       1460       1470       1480       1490       1500 
RTGTEAEDVL GELEYDKVPY SSLRRTLDQR RALVMQLFQD HGFFPSAQAT AAFQARYADI 

      1510       1520       1530       1540       1550       1560 
FPSKVCLQLK IREVRQKIMQ AATPTEQPPG AEAPLPVPPP TGTAAAPAPT PSPAGGPDPT 

      1570       1580       1590       1600 
SPSSDSGTAQ AAPPLPPPPE SGPGQPGWEG APQPSPPPPG PSTAATGR 

Q96RK0 in FASTA format

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