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UniProtKB/Swiss-Prot entry Q96PU8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name QKI_HUMAN
Primary accession number Q96PU8
Secondary accession numbers Q2I375 Q5MJQ1 Q969L9 Q96EJ3 Q96KA3 Q96PU6 Q96PU7 Q9P0X6 Q9P0X7 Q9P0X8 Q9P0X9 Q9P0Y0 Q9P0Y1
Integrated into Swiss-Prot on June 13, 2006
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    July 1, 2008 (Entry version 53)
Name and origin of the protein
Protein name Protein quaking
Synonyms HqkI
Hqk
Gene name
Name: QKI
Synonyms: HKQ
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 6 AND 8).
TISSUE=Brain;
PubMed=11856480 [NCBI, ExPASy, EBI, Israel, Japan]
Li Z.Z., Kondo T., Murata T., Ebersole T.A., Nishi T., Tada K., Ushio Y., Yamamura K., Abe K.;
"Expression of Hqk encoding a KH RNA binding protein is altered in human glioma.";
Jpn. J. Cancer Res. 93:167-177(2002).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 7), AND NUCLEOTIDE SEQUENCE [MRNA] OF 5-341 (ISOFORM 9).
Xia J.-H., Xiao J.-F., He Y.-G., Yu K.-P., Pan Q., Dai H.-P.;
"Molecular cloning of human QUAKING gene.";
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-341 (ISOFORM 5).
Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Liang M., Tang Z., Huang B., Lin L., Yang S.;
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02055; PubMed=14574404 [NCBI, ExPASy, EBI, Israel, Japan]
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Placenta, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-341.
TISSUE=Embryo;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[7]
POSSIBLE INVOLVEMENT IN SCHIZOPHRENIA.
DOI=10.1002/ajmg.b.30243; PubMed=16342280 [NCBI, ExPASy, EBI, Israel, Japan]
Aeberg K., Saetre P., Lindholm E., Ekholm B., Pettersson U., Adolfsson R., Jazin E.;
"Human QKI, a new candidate gene for schizophrenia involved in myelination.";
Am. J. Med. Genet. B Neuropsychiatr. Genet. 141:84-90(2006).
[8]
POSSIBLE INVOLVEMENT IN ASTROCYTIC TUMORS.
DOI=10.1038/sj.onc.1209156; PubMed=16205629 [NCBI, ExPASy, EBI, Israel, Japan]
Ichimura K., Mungall A.J., Fiegler H., Pearson D.M., Dunham I., Carter N.P., Collins V.P.;
"Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH.";
Oncogene 25:1261-1271(2006).
[9]
POSSIBLE INVOLVEMENT IN SCHIZOPHRENIA.
DOI=10.1073/pnas.0601213103; PubMed=16641098 [NCBI, ExPASy, EBI, Israel, Japan]
Aberg K., Saetre P., Jareborg N., Jazin E.;
"Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia.";
Proc. Natl. Acad. Sci. U.S.A. 103:7482-7487(2006).
[10]
VARIANT [LARGE SCALE ANALYSIS] GLN-336.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB067798; BAB69496.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB067799; BAB69497.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB067800; BAB69498.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB067801; BAB69499.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB067808; BAB69681.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF142417; AAF63412.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF142418; AAF63413.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF142419; AAF63414.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF142420; AAF63415.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF142421; AAF63416.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF142422; AAF63417.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY780788; AAV98358.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ323998; ABC88600.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL356119; CAI23022.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031781; CAI23022.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL356119; CAI23023.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031781; CAI23023.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL356119; CAI23024.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031781; CAI23024.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031781; CAI21651.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL356119; CAI21651.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031781; CAI21652.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL356119; CAI21652.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031781; CAI21653.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL356119; CAI21653.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC012222; AAH12222.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC019917; AAH19917.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK027309; BAB55032.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_006766.1; -.
NP_996735.1; -.
NP_996736.1; -.
NP_996737.1; -.
UniGene Hs.510324
3D structure databases
HSSP Q9BW01; 1K1G. [HSSP ENTRY / PDB]
SMR Q96PU8; 81-214.
ModBase Q96PU8.
Protein-protein interaction databases
IntAct Q96PU8; -.
Organism-specific databases
H-InvDB HIX0006359; -.
HGNC HGNC:21100; QKI.
GeneLynx QKI; Homo sapiens.
GenAtlas QKI.
MIM 609590; gene. [NCBI / EBI]
PharmGKB PA134912180; -.
GeneCards Q96PU8.
Gene expression databases
ArrayExpress Q96PU8; -.
GermOnline ENSG00000112531; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR004087; KH.
IPR004088; KH_type_1.
Graphical view of domain structure.
Pfam PF00013; KH_1; 1.
Pfam graphical view of domain structure.
SMART SM00322; KH; 1.
SMART graphical view of domain structure.
PROSITE PS50084; KH_TYPE_1; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q96PU8.
Genome annotation databases
Ensembl ENSG00000112531; Homo sapiens. [Contig view]
GeneID 9444; -.
KEGG hsa:9444; -.
Phylogenomic databases
HOVERGEN Q96PU8; -.
Other
SOURCE QKI; Homo sapiens.
ProtoNet Q96PU8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cytoplasm; Developmental protein; Differentiation; Methylation; mRNA processing; mRNA splicing; mRNA transport; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; SH3-binding; Translation regulation; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   341  341     Protein quaking. PRO_0000239373
DOMAIN   87   153  67     KH. 
MOTIF   276   279  4     SH3-binding. 
MOTIF   324   330  7     Nuclear localization signal (By similarity). 
VAR_SEQ   1     1        M -> MLSLSSLRRNSGRNSGSCGAWNM (in isoform 2, isoform 4 and isoform 7). VSP_019187
VAR_SEQ   213   220        Missing (in isoform 3 and isoform 5). VSP_019188
VAR_SEQ   312   341        GAVATKVRRHDMRVHPYQRIVTADRAATGN -> GMAFPTKG (in isoform 2). VSP_019189
VAR_SEQ   312   341        GAVATKVRRHDMRVHPYQRIVTADRAATGN -> EWIEMPVMPDISAH (in isoform 5, isoform 6 and isoform 7). VSP_019190
VAR_SEQ   312   341        GAVATKVRRHDMRVHPYQRIVTADRAATGN -> GKFFSPWG (in isoform 8). VSP_019191
VARIANT   336   336  1     R -> Q (in a colorectal cancer sample; somatic mutation). VAR_036051 
CONFLICT   30    30        S -> G (in Ref. 3; ABC88600). 
CONFLICT   208   208        N -> D (in Ref. 5; AAH12222). 
Sequence information
Length: 341 AA [This is the length of the unprocessed precursor] Molecular weight: 37671 Da [This is the MW of the unprocessed precursor] CRC64: 43E7F3A426A494C4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT 

        70         80         90        100        110        120 
LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK 

       130        140        150        160        170        180 
IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV 

       190        200        210        220        230        240 
PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA 

       250        260        270        280        290        300 
LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI 

       310        320        330        340 
LEYPIEPSGV LGAVATKVRR HDMRVHPYQR IVTADRAATG N 

Q96PU8 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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