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UniProtKB/Swiss-Prot entry Q96KC8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNJC1_HUMAN
Primary accession number Q96KC8
Secondary accession numbers B0YIZ8 Q5VX89 Q9H6B8
Integrated into Swiss-Prot on January 17, 2003
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 70)
Name and origin of the protein
Protein name DnaJ homolog subfamily C member 1 [Precursor]
Synonym DnaJ protein homolog MTJ1
Gene name
Name: DNAJC1
Synonyms: HTJ1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH SERPINA3.
TISSUE=Liver;
DOI=10.1074/jbc.M310903200; PubMed=14668352 [NCBI, ExPASy, EBI, Israel, Japan]
Kroczynska B., Evangelista C.M., Samant S.S., Elguindi E.C., Blond S.Y.;
"The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity.";
J. Biol. Chem. 279:11432-11443(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
NHLBI resequencing and genotyping service (RS&G);
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02462; PubMed=15164054 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381 AND SER-430, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[7]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
[8]
STRUCTURE BY NMR OF 327-385 AND 484-543.
RIKEN structural genomics initiative (RSGI);
"Solution structure of RSGI RUH-037, a Myb DNA-binding domain in human.";
Submitted (NOV-2005) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY225122; AAP50497.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK026062; BAB15343.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK027263; BAB55004.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EF444973; ACA05978.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EF444973; ACA05979.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL445431; CAI13668.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL359697; CAI13668.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL359697; CAH73412.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL445431; CAH73412.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC110894; AAI10895.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00074870; -.
RefSeq NP_071760.2; -.
UniGene Hs.499000
3D structure databases
PDB
2CQQ; NMR; -; A=327-385.[ExPASy / RCSB / EBI]
2CQR; NMR; -; A=484-543.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2CQQ; -.
2CQR; -.
ModBase Q96KC8.
Protein-protein interaction databases
IntAct Q96KC8; 3.
PTM databases
PhosphoSite Q96KC8; -.
Organism-specific databases
GeneCards GC10M022085; -.
HGNC HGNC:20090; DNAJC1.
GenAtlas DNAJC1.
HPA HPA013432; -.
MIM 611207; gene. [NCBI / EBI]
PharmGKB PA128394706; -.
Gene expression databases
ArrayExpress Q96KC8; -.
Bgee Q96KC8; -.
CleanEx HS_DNAJC1; -.
GermOnline ENSG00000136770; Homo sapiens.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005792; Cellular component: microsome (inferred from electronic annotation from UniProtKB-SubCell).
GO:0031965; Cellular component: nuclear membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0001671; Molecular function: ATPase activator activity (traceable author statement from UniProtKB).
GO:0003677; Molecular function: DNA binding (inferred from electronic annotation from UniProtKB-KW).
GO:0031072; Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
GO:0051082; Molecular function: unfolded protein binding (inferred from electronic annotation from InterPro).
GO:0045861; Biological process: negative regulation of proteolysis (traceable author statement from UniProtKB).
GO:0050708; Biological process: regulation of protein secretion (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001623; DnaJ_N.
IPR018253; Heat_shock_DnaJ_CS.
IPR015609; Hsp40/DnaJ_Rel.
IPR003095; Hsp_DnaJ.
IPR014778; Myb_DNA-bd.
IPR001005; SANT_DNA-bd.
IPR017884; SANT_eukarya.
Graphical view of domain structure.
Gene3D G3DSA:1.10.287.110; DnaJ_N; 1.
PANTHER PTHR11821; Hsp40/DnaJ_Rel; 1.
Pfam PF00226; DnaJ; 1.
PF00249; Myb_DNA-binding; 1.
Pfam graphical view of domain structure.
PRINTS PR00625; DNAJPROTEIN.
SMART SM00271; DnaJ; 1.
SM00717; SANT; 2.
SMART graphical view of domain structure.
PROSITE PS00636; DNAJ_1; 1.
PS50076; DNAJ_2; 1.
PS51293; SANT; 2.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q96KC8; -.
Genome annotation databases
Ensembl ENSG00000136770; Homo sapiens. [Contig view]
GeneID 64215; -.
KEGG hsa:64215; -.
Phylogenomic databases
HOGENOM Q96KC8; -.
HOVERGEN Q96KC8; -.
OMA Q96KC8; TQREDAE.
Other
NextBio 66123; -.
SOURCE DNAJC1; Homo sapiens.
ProtoNet Q96KC8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Chaperone; DNA-binding; Endoplasmic reticulum; Membrane; Microsome; Nucleus; Phosphoprotein; Repeat; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    47  47     Potential. 
CHAIN   48   554  507     DnaJ homolog subfamily C member 1. PRO_0000071042
TOPO_DOM   48   153  106     Lumenal (By similarity). 
TRANSMEM   154   174  21     Potential. 
TOPO_DOM   175   554  380     Cytoplasmic (By similarity). 
DOMAIN   65   129  65     J. 
DOMAIN   325   379  55     SANT 1. 
DOMAIN   492   547  56     SANT 2. 
MOD_RES   363   363        Phosphoserine (By similarity). 
MOD_RES   365   365        Phosphothreonine (By similarity). 
MOD_RES   381   381        Phosphoserine. 
MOD_RES   430   430        Phosphoserine. 
MOD_RES   479   479        Phosphoserine (By similarity). 
MOD_RES   480   480        Phosphoserine (By similarity). 
HELIX   332   344  13      
HELIX   352   360  9      
HELIX   364   376  13      
TURN   489   491  3      
HELIX   499   511  13      
STRAND   514   516  3      
HELIX   517   523  7      
HELIX   524   526  3      
STRAND   528   530  3      
Sequence information
Length: 554 AA [This is the length of the unprocessed precursor] Molecular weight: 63883 Da [This is the MW of the unprocessed precursor] CRC64: 65EAAB16C65E2B46 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTAPCSQPAQ LPGRRQLGLV PFPPPPPRTP LLWLLLLLLA AVAPARGWES GDLELFDLVE 

        70         80         90        100        110        120 
EVQLNFYQFL GVQQDASSAD IRKAYRKLSL TLHPDKNKDE NAETQFRQLV AIYEVLKDDE 

       130        140        150        160        170        180 
RRQRYDDILI NGLPDWRQPV FYYRRVRKMS NAELALLLFI ILTVGHYAVV WSIYLEKQLD 

       190        200        210        220        230        240 
ELLSRKKREK KKKTGSKSVD VSKLGASEKN ERLLMKPQWH DLLPCKLGIW FCLTLKALPH 

       250        260        270        280        290        300 
LIQDAGQFYA KYKETRLKEK EDALTRTELE TLQKQKKVKK PKPEFPVYTP LETTYIQSYD 

       310        320        330        340        350        360 
HGTSIEEIEE QMDDWLENRN RTQKKQAPEW TEEDLSQLTR SMVKFPGGTP GRWEKIAHEL 

       370        380        390        400        410        420 
GRSVTDVTTK AKQLKDSVTC SPGMVRLSEL KSTVQNSRPI KTATTLPDDM ITQREDAEGV 

       430        440        450        460        470        480 
AAEEEQEGDS GEQETGATDA RPRRRKPARL LEATAKPEPE EKSRAKRQKD FDIAEQNESS 

       490        500        510        520        530        540 
DEESLRKERA RSAEEPWTQN QQKLLELALQ QYPRGSSDRW DKIARCVPSK SKEDCIARYK 

       550 
LLVELVQKKK QAKS 

Q96KC8 in FASTA format

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