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UniProtKB/Swiss-Prot entry Q96JB6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LOXL4_HUMAN
Primary accession number Q96JB6
Secondary accession numbers Q96DY1 Q96PC0 Q9H6T5
Integrated into Swiss-Prot on April 16, 2002
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 76)
Name and origin of the protein
Protein name Lysyl oxidase homolog 4 [Precursor]
Synonyms EC 1.4.3.-
Lysyl oxidase-like protein 4
Lysyl oxidase-related protein C
Gene name
Name: LOXL4
Synonyms: LOXC
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
DOI=10.1074/jbc.M100861200; PubMed=11292829 [NCBI, ExPASy, EBI, Israel, Japan]
Ito H., Akiyama H., Iguchi H., Iyama K., Miyamoto M., Ohsawa K., Nakamura T.;
"Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage.";
J. Biol. Chem. 276:24023-24029(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/S0945-053X(01)00157-3; PubMed=11691589 [NCBI, ExPASy, EBI, Israel, Japan]
Maeki J.M., Tikkanen H., Kivirikko K.I.;
"Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains.";
Matrix Biol. 20:493-496(2001).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
DOI=10.1016/S0945-053X(01)00161-5; PubMed=11691588 [NCBI, ExPASy, EBI, Israel, Japan]
Asuncion L., Fogelgren B., Fong K.S.K., Fong S.F.T., Kim Y., Csiszar K.;
"A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain.";
Matrix Biol. 20:487-491(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-405.
TISSUE=Eye;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 492-756.
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-383, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF338441; AAK71934.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY036093; AAK64186.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF395336; AAL27543.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007522; AAH07522.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC013153; AAH13153.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK025542; BAB15167.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00306402; -.
RefSeq NP_115587.6; -.
UniGene Hs.306814
3D structure databases
ModBase Q96JB6.
Protein-protein interaction databases
IntAct Q96JB6; 1.
Organism-specific databases
GeneCards GC10M099997; -.
H-InvDB HIX0009104; -.
HGNC HGNC:17171; LOXL4.
GenAtlas LOXL4.
MIM 607318; gene. [NCBI / EBI]
PharmGKB PA30431; -.
Gene expression databases
ArrayExpress Q96JB6; -.
Bgee Q96JB6; -.
CleanEx HS_LOXL4; -.
GermOnline ENSG00000138131; Homo sapiens.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016020; Cellular component: membrane (inferred from electronic annotation from InterPro).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005044; Molecular function: scavenger receptor activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001695; Lysyl_oxidase.
IPR019828; Lysyl_oxidase_CS.
IPR001190; Srcr_rcpt.
IPR017448; Srcr_rcpt-rel.
Graphical view of domain structure.
Pfam PF01186; Lysyl_oxidase; 1.
PF00530; SRCR; 4.
Pfam graphical view of domain structure.
PRINTS PR00074; LYSYLOXIDASE.
ProDom PD013887; Lysyl_oxidase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00202; SR; 4.
SMART graphical view of domain structure.
PROSITE PS00926; LYSYL_OXIDASE; 1.
PS00420; SRCR_1; 1.
PS50287; SRCR_2; 4.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q96JB6; -.
Genome annotation databases
Ensembl ENSG00000138131; Homo sapiens. [Contig view]
GeneID 84171; -.
KEGG hsa:84171; -.
Phylogenomic databases
HOGENOM Q96JB6; -.
HOVERGEN Q96JB6; -.
OMA Q96JB6; GFQNQVR.
Other
NextBio 73532; -.
SOURCE LOXL4; Homo sapiens.
ProtoNet Q96JB6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Copper; Disulfide bond; Glycoprotein; LTQ; Metal-binding; Oxidoreductase; Phosphoprotein; Polymorphism; Repeat; Secreted; Signal; TPQ.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    24  24     Potential. 
CHAIN   25   756  732     Lysyl oxidase homolog 4. PRO_0000018535
DOMAIN   32   133  102     SRCR 1. 
DOMAIN   159   287  129     SRCR 2. 
DOMAIN   311   411  101     SRCR 3. 
DOMAIN   421   529  109     SRCR 4. 
REGION   533   736  204     Lysyl-oxidase like. 
METAL   611   611        Copper (Potential). 
METAL   613   613        Copper (Potential). 
METAL   615   615        Copper (Potential). 
MOD_RES   383   383        Phosphotyrosine. 
MOD_RES   674   674        2',4',5'-topaquinone (By similarity). 
CARBOHYD   198   198        N-linked (GlcNAc...) (Potential). 
CARBOHYD   629   629        N-linked (GlcNAc...) (Potential). 
DISULFID   58   122        By similarity. 
DISULFID   71   132        By similarity. 
DISULFID   102   112        By similarity. 
DISULFID   191   276        By similarity. 
DISULFID   204   286        By similarity. 
DISULFID   251   261        By similarity. 
DISULFID   336   400        By similarity. 
DISULFID   349   410        By similarity. 
DISULFID   380   390        By similarity. 
DISULFID   450   515        By similarity. 
DISULFID   463   528        By similarity. 
DISULFID   497   507        By similarity. 
CROSSLNK   638   674        Lysine tyrosylquinone (Lys-Tyr) (By similarity). 
VARIANT   154   154  1     R -> Q (in dbSNP:rs33995374 [NCBI]). VAR_050012 
VARIANT   405   405  1     D -> A (in dbSNP:rs1983864 [NCBI]). VAR_050013 
CONFLICT   3     3        W -> R (in Ref. 4; AAH13153). 
CONFLICT   101   101        R -> Q (in Ref. 4; AAH13153). 
CONFLICT   493   493        S -> G (in Ref. 3; AAL27543). 
CONFLICT   539   539        A -> T (in Ref. 3; AAL27543). 
CONFLICT   542   542        V -> A (in Ref. 3; AAL27543). 
CONFLICT   703   703        Y -> H (in Ref. 3; AAL27543). 
Sequence information
Length: 756 AA [This is the length of the unprocessed precursor] Molecular weight: 84483 Da [This is the MW of the unprocessed precursor] CRC64: 13051ACADB922BBC [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAWSPPATLF LFLLLLGQPP PSRPQSLGTT KLRLVGPESK PEEGRLEVLH QGQWGTVCDD 

        70         80         90        100        110        120 
NFAIQEATVA CRQLGFEAAL TWAHSAKYGQ GEGPIWLDNV RCVGTESSLD QCGSNGWGVS 

       130        140        150        160        170        180 
DCSHSEDVGV ICHPRRHRGY LSETVSNALG PQGRRLEEVR LKPILASAKQ HSPVTEGAVE 

       190        200        210        220        230        240 
VKYEGHWRQV CDQGWTMNNS RVVCGMLGFP SEVPVDSHYY RKVWDLKMRD PKSRLKSLTN 

       250        260        270        280        290        300 
KNSFWIHQVT CLGTEPHMAN CQVQVAPARG KLRPACPGGM HAVVSCVAGP HFRPPKTKPQ 

       310        320        330        340        350        360 
RKGSWAEEPR VRLRSGAQVG EGRVEVLMNR QWGTVCDHRW NLISASVVCR QLGFGSAREA 

       370        380        390        400        410        420 
LFGARLGQGL GPIHLSEVRC RGYERTLSDC PALEGSQNGC QHENDAAVRC NVPNMGFQNQ 

       430        440        450        460        470        480 
VRLAGGRIPE EGLLEVQVEV NGVPRWGSVC SENWGLTEAM VACRQLGLGF AIHAYKETWF 

       490        500        510        520        530        540 
WSGTPRAQEV VMSGVRCSGT ELALQQCQRH GPVHCSHGGG RFLAGVSCMD SAPDLVMNAQ 

       550        560        570        580        590        600 
LVQETAYLED RPLSQLYCAH EENCLSKSAD HMDWPYGYRR LLRFSTQIYN LGRTDFRPKT 

       610        620        630        640        650        660 
GRDSWVWHQC HRHYHSIEVF THYDLLTLNG SKVAEGHKAS FCLEDTNCPT GLQRRYACAN 

       670        680        690        700        710        720 
FGEQGVTVGC WDTYRHDIDC QWVDITDVGP GNYIFQVIVN PHYEVAESDF SNNMLQCRCK 

       730        740        750 
YDGHRVWLHN CHTGNSYPAN AELSLEQEQR LRNNLI 

Q96JB6 in FASTA format

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