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UniProtKB/Swiss-Prot entry Q96AY3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FKB10_HUMAN
Primary accession number Q96AY3
Secondary accession numbers Q7Z3R4 Q9H3N3 Q9H6N5 Q9UF89
Integrated into Swiss-Prot on September 19, 2002
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 67)
Name and origin of the protein
Protein name FK506-binding protein 10 [Precursor]
Synonyms EC 5.2.1.8
Peptidyl-prolyl cis-trans isomerase
PPIase
Rotamase
Immunophilin FKBP65
65 kDa FK506-binding protein
FKBP65
Gene name
Name: FKBP10
Synonyms: FKBP65
ORFNames: PSEC0056
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
Rulten S., Kinloch R.A., Robinson C., Gettins L., Kay J.E.;
"The human FK506-binding protein repertoire.";
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Teratocarcinoma;
Ota T., Nishikawa T., Kawai Y., Suzuki Y., Ishii S., Saito K., Yamamoto J., Sugano S., Isogai T.;
"HRI human cDNA sequencing project.";
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Endometrial tumor, and Uterus;
The German cDNA consortium;
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-582.
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
GLYCOSYLATION AT ASN-182 AND ASN-407.
DOI=10.1038/nbt827; PubMed=12754519 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang H., Li X.-J., Martin D.B., Aebersold R.;
"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.";
Nat. Biotechnol. 21:660-666(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF337909; AAM15770.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB045981; BAB20974.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX537452; CAD97695.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL133116; CAB61418.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC016467; AAH16467.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK025694; BAB15220.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T42709; T42709.
RefSeq NP_068758.3; -.
UniGene Hs.463035
3D structure databases
HSSP P20081; 1YAT. [HSSP ENTRY / PDB]
ModBase Q96AY3.
Organism-specific databases
H-InvDB HIX0013820; -.
HGNC HGNC:18169; FKBP10.
GenAtlas FKBP10.
MIM 607063; gene. [NCBI / EBI]
PharmGKB PA28152; -.
GeneCards Q96AY3.
Gene expression databases
ArrayExpress Q96AY3; -.
CleanEx HS_FKBP10; -.
GermOnline ENSG00000141756; Homo sapiens.
Ontologies
GO
GO:0005788; Cellular component: endoplasmic reticulum lumen (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002048; EF_hand_Ca_bd.
IPR000886; ER_targeting_sequence.
IPR001179; PPIase_FKBP.
Graphical view of domain structure.
PANTHER PTHR10516; PPIase_FKBP; 1.
Pfam PF00036; efhand; 2.
PF00254; FKBP_C; 4.
Pfam graphical view of domain structure.
SMART SM00054; EFh; 2.
SMART graphical view of domain structure.
PROSITE PS00018; EF_HAND_1; 1.
PS50222; EF_HAND_2; 2.
PS00014; ER_TARGET; 1.
PS50059; FKBP_PPIASE; 4.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q96AY3.
Proteomic databases
PeptideAtlas Q96AY3; -.
Genome annotation databases
Ensembl ENSG00000141756; Homo sapiens. [Contig view]
GeneID 60681; -.
KEGG hsa:60681; -.
Phylogenomic databases
HOGENOM Q96AY3; -.
HOVERGEN Q96AY3; -.
Other
SOURCE FKBP10; Homo sapiens.
ProtoNet Q96AY3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Endoplasmic reticulum; Glycoprotein; Isomerase; Phosphoprotein; Repeat; Rotamase; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    26  26     Potential. 
CHAIN   27   582  556     FK506-binding protein 10. PRO_0000025517
DOMAIN   62   150  89     PPIase FKBP-type 1. 
DOMAIN   174   262  89     PPIase FKBP-type 2. 
DOMAIN   286   374  89     PPIase FKBP-type 3. 
DOMAIN   399   486  88     PPIase FKBP-type 4. 
DOMAIN   497   532  36     EF-hand 1. 
DOMAIN   542   577  36     EF-hand 2. 
CA_BIND   510   521  12     1 (Potential). 
CA_BIND   555   566  12     2 (Potential). 
MOTIF   579   582  4     Prevents secretion from ER (Potential). 
CARBOHYD   70    70        N-linked (GlcNAc...) (Potential). 
CARBOHYD   182   182        N-linked (GlcNAc...). 
CARBOHYD   294   294        N-linked (GlcNAc...) (Potential). 
CARBOHYD   310   310        N-linked (GlcNAc...) (Potential). 
CARBOHYD   352   352        N-linked (GlcNAc...) (Potential). 
CARBOHYD   393   393        N-linked (GlcNAc...) (Potential). 
CARBOHYD   407   407        N-linked (GlcNAc...). 
CONFLICT   190   190        S -> F (in Ref. 2; BAB20974). 
CONFLICT   456   456        V -> L (in Ref. 3; CAD97695). 
Sequence information
Length: 582 AA [This is the length of the unprocessed precursor] Molecular weight: 64245 Da [This is the MW of the unprocessed precursor] CRC64: 98257459158407C2 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFPAGPPSHS LLRLPLLQLL LLVVQAVGRG LGRASPAGGP LEDVVIERYH IPRACPREVQ 

        70         80         90        100        110        120 
MGDFVRYHYN GTFEDGKKFD SSYDRNTLVA IVVGVGRLIT GMDRGLMGMC VNERRRLIVP 

       130        140        150        160        170        180 
PHLGYGSIGL AGLIPPDATL YFDVVLLDVW NKEDTVQVST LLRPPHCPRM VQDGDFVRYH 

       190        200        210        220        230        240 
YNGTLLDGTS FDTSYSKGGT YDTYVGSGWL IKGMDQGLLG MCPGERRKII IPPFLAYGEK 

       250        260        270        280        290        300 
GYGTVIPPQA SLVFHVLLID VHNPKDAVQL ETLELPPGCV RRAGAGDFMR YHYNGSLMDG 

       310        320        330        340        350        360 
TLFDSSYSRN HTYNTYIGQG YIIPGMDQGL QGACMGERRR ITIPPHLAYG ENGTGDKIPG 

       370        380        390        400        410        420 
SAVLIFNVHV IDFHNPADVV EIRTLSRPSE TCNETTKLGD FVRYHYNCSL LDGTQLFTSH 

       430        440        450        460        470        480 
DYGAPQEATL GANKVIEGLD TGLQGMCVGE RRQLIVPPHL AHGESGARGV PGSAVLLFEV 

       490        500        510        520        530        540 
ELVSREDGLP TGYLFVWHKD PPANLFEDMD LNKDGEVPPE EFSTFIKAQV SEGKGRLMPG 

       550        560        570        580 
QDPEKTIGDM FQNQDRNQDG KITVDELKLK SDEDEERVHE EL 

Q96AY3 in FASTA format

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