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UniProtKB/Swiss-Prot entry Q93062


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RBPMS_HUMAN
Primary accession number Q93062
Secondary accession numbers Q92516 Q92517 Q92518 Q96J26
Integrated into Swiss-Prot on February 21, 2001
Sequence was last modified on February 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 78)
Name and origin of the protein
Protein name RNA-binding protein with multiple splicing
Synonym RBP-MS
Gene name
Name: RBPMS
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D AND E).
TISSUE=Lip;
DOI=10.1073/pnas.93.20.10913; PubMed=8855282 [NCBI, ExPASy, EBI, Israel, Japan]
Shimamoto A., Kitao S., Ichikawa K., Suzuki N., Yamabe Y., Imamura O., Tokutake Y., Satoh M., Matsumoto T., Kuromitsu J., Kataoka H., Sugawara K., Sugawara M., Sugimoto M., Goto M., Furuichi Y.;
"A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs.";
Proc. Natl. Acad. Sci. U.S.A. 93:10913-10917(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
DOI=10.1186/gb-2004-5-2-r8; PubMed=14759258 [NCBI, ExPASy, EBI, Israel, Japan]
Hillman R.T., Green R.E., Brenner S.E.;
"An unappreciated role for RNA surveillance.";
Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D84110; BAA12228.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84107; BAA12225.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84108; BAA12226.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84109; BAA12227.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D84111; BAA12229.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC003608; AAH03608.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC6127; JC6127.
RefSeq NP_001008710.1; -.
NP_001008711.1; -.
NP_001008712.1; -.
NP_006858.1; -.
UniGene Hs.334587
3D structure databases
PDB
1BNY; Model; -; A=15-111.[ExPASy / RCSB / EBI]
PDBsum 1BNY; -.
ModBase Q93062.
Protein-protein interaction databases
IntAct Q93062; -.
Organism-specific databases
H-InvDB HIX0007433; -.
HGNC HGNC:19097; RBPMS.
GenAtlas RBPMS.
MIM 601558; gene. [NCBI / EBI]
PharmGKB PA134985584; -.
GeneCards Q93062.
Gene expression databases
ArrayExpress Q93062; -.
CleanEx HS_RBPMS; -.
GermOnline ENSG00000157110; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0003723; Molecular function: RNA binding (traceable author statement from ProtInc).
GO:0006396; Biological process: RNA processing (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR012677; a_b_plait_nuc_bd.
IPR000504; RRM_RNP1.
Graphical view of domain structure.
Gene3D G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
Pfam PF00076; RRM_1; 1.
Pfam graphical view of domain structure.
SMART SM00360; RRM; 1.
SMART graphical view of domain structure.
PROSITE PS50102; RRM; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q93062.
Genome annotation databases
Ensembl ENSG00000157110; Homo sapiens. [Contig view]
GeneID 11030; -.
KEGG hsa:11030; -.
Phylogenomic databases
HOVERGEN Q93062; -.
Other
LinkHub Q93062; -.
SOURCE RBPMS; Homo sapiens.
ProtoNet Q93062.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; RNA-binding.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   196  196     RNA-binding protein with multiple splicing. PRO_0000081793
DOMAIN   24   101  78     RRM. 
VAR_SEQ   133   196        YELTVPALYPSSPEVWAPYPLYPAELAPALPPPAFTYPAS LHAQMRWLPPSEATSQGWKSRQFC -> LGGANEHGERQ (in isoform D). VSP_005815
VAR_SEQ   133   176        Missing (in isoform E). VSP_005816
VAR_SEQ   177   196        MRWLPPSEATSQGWKSRQFC -> LCEGQTVRRSHPLSAPSPDSASLAWFPV (in isoform B). VSP_005813
VAR_SEQ   177   196        MRWLPPSEATSQGWKSRQFC -> CFSPEAKPNTPVFCPLLQQIRFVSGNVFVTYQPTADQQ RELPC (in isoform C). VSP_005814
STRAND   24    29  6      
HELIX   40    47  8      
TURN   48    50  3      
STRAND   53    57  5      
STRAND   60    62  3      
STRAND   65    70  6      
HELIX   72    81  10      
STRAND   92    95  4      
HELIX   101   104  4      
Sequence information
Length: 196 AA [This is the length of the unprocessed precursor] Molecular weight: 21802 Da [This is the MW of the unprocessed precursor] CRC64: 05DD964E62F8F88C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNNGGKAEKE NTPSEANLQE EEVRTLFVSG LPLDIKPREL YLLFRPFKGY EGSLIKLTSK 

        70         80         90        100        110        120 
QPVGFVSFDS RSEAEAAKNA LNGIRFDPEI PQTLRLEFAK ANTKMAKNKL VGTPNPSTPL 

       130        140        150        160        170        180 
PNTVPQFIAR EPYELTVPAL YPSSPEVWAP YPLYPAELAP ALPPPAFTYP ASLHAQMRWL 

       190 
PPSEATSQGW KSRQFC 

Q93062 in FASTA format

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