ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q93033


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name IGSF2_HUMAN
Primary accession number Q93033
Secondary accession number Q15856
Integrated into Swiss-Prot on October 17, 2006
Sequence was last modified on February 10, 2009 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 64)
Name and origin of the protein
Protein name Immunoglobulin superfamily member 2 [Precursor]
Synonyms Glu-Trp-Ile EWI motif-containing protein 101
EWI-101
Cell surface glycoprotein V7
CD101 antigen
Gene name
Name: IGSF2
Synonyms: CD101, EWI101, V7
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT VAL-415.
PubMed=7722300 [NCBI, ExPASy, EBI, Israel, Japan]
Ruegg C.L., Rivas A., Madani N.D., Zeitung J., Laus R., Engleman E.G.;
"V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene.";
J. Immunol. 154:4434-4443(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[3]
FUNCTION, GLYCOSYLATION, AND TISSUE SPECIFICITY.
PubMed=7722299 [NCBI, ExPASy, EBI, Israel, Japan]
Rivas A., Ruegg C.L., Zeitung J., Laus R., Warnke R., Benike C., Engleman E.G.;
"V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies.";
J. Immunol. 154:4423-4433(1995).
[4]
FUNCTION.
PubMed=9233604 [NCBI, ExPASy, EBI, Israel, Japan]
Soares L.R.B., Rivas A., Tsavaler L., Engleman E.G.;
"Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism.";
J. Immunol. 159:1115-1124(1997).
[5]
TISSUE SPECIFICITY, AND FUNCTION.
DOI=10.1111/j.1399-0039.1997.tb02898.x; PubMed=9389317 [NCBI, ExPASy, EBI, Israel, Japan]
Bagot M., Martinel I., Charue D., Weill F., Boulland M.-L., Wechsler J., Freeman G.J., Bensussan A., Boumsell L.;
"CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation.";
Tissue Antigens 50:439-448(1997).
[6]
FUNCTION.
PubMed=9647226 [NCBI, ExPASy, EBI, Israel, Japan]
Soares L.R.B., Tsavaler L., Rivas A., Engleman E.G.;
"V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation.";
J. Immunol. 161:209-217(1998).
[7]
FUNCTION.
DOI=10.1002/1521-4141(200011)30:11<3132::AID-IMMU3132>3.0.CO;2-E; PubMed=11093127 [NCBI, ExPASy, EBI, Israel, Japan]
Bouloc A., Bagot M., Delaire S., Bensussan A., Boumsell L.;
"Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production.";
Eur. J. Immunol. 30:3132-3139(2000).
[8]
TISSUE SPECIFICITY.
DOI=10.1046/j.1365-2559.2000.00827.x; PubMed=10692025 [NCBI, ExPASy, EBI, Israel, Japan]
Bouloc A., Boulland M.-L., Geissmann F., Fraitag S., Andry P., Teillac D., Bensussan A., Revuz J., Boumsell L., Wechsler J., Bagot M.;
"CD101 expression by Langerhans cell histiocytosis cells.";
Histopathology 36:229-232(2000).
[9]
DOMAIN EWI MOTIF.
DOI=10.1074/jbc.M107338200; PubMed=11504738 [NCBI, ExPASy, EBI, Israel, Japan]
Stipp C.S., Kolesnikova T.V., Hemler M.E.;
"EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.";
J. Biol. Chem. 276:40545-40554(2001).
[10]
FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1111/j.0022-202X.2005.23617.x; PubMed=15737213 [NCBI, ExPASy, EBI, Israel, Japan]
Meyer N., Petrella T., Poszepczynska-Guigne E., Boumsell L., Wechsler J., Bensussan A., Bagot M.;
"CD4+ CD56+ blastic tumor cells express CD101 molecules.";
J. Invest. Dermatol. 124:668-669(2005).
Comments
  • FUNCTION: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.
  • SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
  • TISSUE SPECIFICITY: Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.
  • PTM: N-glycosylated.
  • SIMILARITY: Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z33642; CAA83923.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL445231; CAH71959.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00003531; -.
PIR I39207; I39207.
RefSeq NP_004249.2; -.
UniGene Hs.654598
3D structure databases
ModBase Q93033.
Protein-protein interaction databases
IntAct Q93033; 4.
PTM databases
PhosphoSite Q93033; -.
Organism-specific databases
GeneCards GC01P117257; -.
H-InvDB HIX0023689; -.
HGNC HGNC:5949; IGSF2.
GenAtlas IGSF2.
MIM 604516; gene. [NCBI / EBI]
PharmGKB PA29762; -.
Gene expression databases
ArrayExpress Q93033; -.
Bgee Q93033; -.
CleanEx HS_IGSF2; -.
GermOnline ENSG00000134256; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (traceable author statement from ProtInc).
GO:0005886; Cellular component: plasma membrane (traceable author statement from ProtInc).
GO:0007166; Biological process: cell surface receptor linked signal transduction (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR013151; Ig.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013106; Ig_V-set.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 4.
Pfam PF00047; ig; 2.
PF07686; V-set; 4.
Pfam graphical view of domain structure.
SMART SM00409; IG; 7.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; 7.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q93033; -.
Genome annotation databases
Ensembl ENSG00000134256; Homo sapiens. [Contig view]
GeneID 9398; -.
KEGG hsa:9398; -.
Phylogenomic databases
HOVERGEN Q93033; -.
OMA Q93033; LELVCLV.
Other
NextBio 35203; -.
SOURCE IGSF2; Homo sapiens.
ProtoNet Q93033.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Repeat; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1     20  20     Potential. 
CHAIN   21   1021  1001     Immunoglobulin superfamily member 2. PRO_0000253539
TOPO_DOM   21    954  934     Extracellular (Potential). 
TRANSMEM   955    975  21     Potential. 
TOPO_DOM   976   1021  46     Cytoplasmic (Potential). 
DOMAIN   22    139  118     Ig-like C2-type 1. 
DOMAIN   144    265  122     Ig-like C2-type 2. 
DOMAIN   279    389  111     Ig-like C2-type 3. 
DOMAIN   408    525  118     Ig-like C2-type 4. 
DOMAIN   541    651  111     Ig-like C2-type 5. 
DOMAIN   656    794  139     Ig-like C2-type 6. 
DOMAIN   808    925  118     Ig-like C2-type 7. 
MOTIF   253    255  3     EWI motif. 
CARBOHYD   44     44        N-linked (GlcNAc...) (Potential). 
CARBOHYD   322    322        N-linked (GlcNAc...) (Potential). 
DISULFID   43    121        By similarity. 
DISULFID   168    249        By similarity. 
DISULFID   304    377        By similarity. 
DISULFID   434    511        By similarity. 
DISULFID   562    640        By similarity. 
DISULFID   697    778        By similarity. 
DISULFID   834    909        By similarity. 
VARIANT   157    157  1     G -> S (in dbSNP:rs34999087 [NCBI]). VAR_054434 
VARIANT   225    225  1     N -> S (in dbSNP:rs3754112 [NCBI]). VAR_028371 
VARIANT   415    415  1     M -> V (in dbSNP:rs2249265 [NCBI]). VAR_028372 
VARIANT   518    518  1     R -> Q (in dbSNP:rs17235766 [NCBI]). VAR_028373 
VARIANT   525    525  1     S -> R (in dbSNP:rs17235773 [NCBI]). VAR_028374 
VARIANT   631    631  1     T -> S (in dbSNP:rs34510762 [NCBI]). VAR_054435 
VARIANT   933    933  1     R -> Q (in dbSNP:rs12093834 [NCBI]). VAR_054436 
VARIANT   955    955  1     L -> F (in dbSNP:rs34223095 [NCBI]). VAR_054437 
VARIANT   965    965  1     V -> I (in dbSNP:rs12097758 [NCBI]). VAR_028375 
VARIANT   988    988  1     R -> C (in dbSNP:rs12067543 [NCBI]). VAR_028376 
VARIANT   992    992  1     R -> W (in dbSNP:rs34248572 [NCBI]). VAR_054438 
CONFLICT   91     91        S -> G (in Ref. 1; CAA83923). 
CONFLICT   129    129        K -> N (in Ref. 1; CAA83923). 
CONFLICT   135    135        S -> R (in Ref. 1; CAA83923). 
CONFLICT   352    352        V -> L (in Ref. 1; CAA83923). 
CONFLICT   684    684        V -> G (in Ref. 1; CAA83923). 
Sequence information
Length: 1021 AA [This is the length of the unprocessed precursor] Molecular weight: 115109 Da [This is the MW of the unprocessed precursor] CRC64: 12A07C648D21EB91 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAGISYVASF FLLLTKLSIG QREVTVQKGP LFRAEGYPVS IGCNVTGHQG PSEQHFQWSV 

        70         80         90        100        110        120 
YLPTNPTQEV QIISTKDAAF SYAVYTQRVR SGDVYVERVQ GNSVLLHISK LQMKDAGEYE 

       130        140        150        160        170        180 
CHTPNTDEKY YGSYSAKTNL IVIPDTLSAT MSSQTLGKEE GEPLALTCEA SKATAQHTHL 

       190        200        210        220        230        240 
SVTWYLTQDG GGSQATEIIS LSKDFILVPG PLYTERFAAS DVQLNKLGPT TFRLSIERLQ 

       250        260        270        280        290        300 
SSDQGQLFCE ATEWIQDPDE TWMFITKKQT DQTTLRIQPA VKDFQVNITA DSLFAEGKPL 

       310        320        330        340        350        360 
ELVCLVVSSG RDPQLQGIWF FNGTEIAHID AGGVLGLKND YKERASQGEL QVSKLGPKAF 

       370        380        390        400        410        420 
SLKIFSLGPE DEGAYRCVVA EVMKTRTGSW QVLQRKQSPD SHVHLRKPAA RSVVMSTKNK 

       430        440        450        460        470        480 
QQVVWEGETL AFLCKAGGAE SPLSVSWWHI PRDQTQPEFV AGMGQDGIVQ LGASYGVPSY 

       490        500        510        520        530        540 
HGNTRLEKMD WATFQLEITF TAITDSGTYE CRVSEKSRNQ ARDLSWTQKI SVTVKSLESS 

       550        560        570        580        590        600 
LQVSLMSRQP QVMLTNTFDL SCVVRAGYSD LKVPLTVTWQ FQPASSHIFH QLIRITHNGT 

       610        620        630        640        650        660 
IEWGNFLSRF QKKTKVSQSL FRSQLLVHDA TEEETGVYQC EVEVYDRNSL YNNRPPRASA 

       670        680        690        700        710        720 
ISHPLRIAVT LPESKLKVNS RSQVQELSIN SNTDIECSIL SRSNGNLQLA IIWYFSPVST 

       730        740        750        760        770        780 
NASWLKILEM DQTNVIKTGD EFHTPQRKQK FHTEKVSQDL FQLHILNVED SDRGKYHCAV 

       790        800        810        820        830        840 
EEWLLSTNGT WHKLGEKKSG LTELKLKPTG SKVRVSKVYW TENVTEHREV AIRCSLESVG 

       850        860        870        880        890        900 
SSATLYSVMW YWNRENSGSK LLVHLQHDGL LEYGEEGLRR HLHCYRSSST DFVLKLHQVE 

       910        920        930        940        950        960 
MEDAGMYWCR VAEWQLHGHP SKWINQASDE SQRMVLTVLP SEPTLPSRIC SSAPLLYFLF 

       970        980        990       1000       1010       1020 
ICPFVLLLLL LISLLCLYWK ARKLSTLRSN TRKEKALWVD LKEAGGVTTN RREDEEEDEG 


N 

Q93033 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!