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UniProtKB/Swiss-Prot entry Q92AH1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_LISIN
Primary accession number Q92AH1
Secondary accession numbers None
Integrated into Swiss-Prot on June 20, 2002
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 48)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: lin1951
From
Listeria innocua [TaxID: 1642] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Listeriaceae; Listeria.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CLIP 11262 / Serovar 6a;
DOI=10.1126/science.1063447; PubMed=11679669 [NCBI, ExPASy, EBI, Israel, Japan]
Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
"Comparative genomics of Listeria species.";
Science 294:849-852(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL596170; CAC97181.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AE1676; AE1676.
RefSeq NP_471285.1; -.
3D structure databases
HSSP P81006; 1GKR. [HSSP ENTRY / PDB]
ModBase Q92AH1.
Protein family/group databases
MEROPS M38.972; -.
Enzyme and pathway databases
BioCyc LINN272626:LIN1951-MON; -.
Organism-specific databases
ListiList LIN01951; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q92AH1.
Genome annotation databases
GeneID 1130647; -.
GenomeReviews AL592022_GR; lin1951.
KEGG lin:lin1951; -.
NMPDR fig|272626.1.peg.1938; -.
Phylogenomic databases
HOGENOM Q92AH1; -.
Genome annotation databases
CMR Q92AH1; lin1951.
Other
ProtoNet Q92AH1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   426  426     Dihydroorotase. PRO_0000147239
METAL   58    58        Zinc 1 (By similarity). 
METAL   60    60        Zinc 1 (By similarity). 
METAL   140   140        Zinc 1 (via carbamate group) (By similarity). 
METAL   140   140        Zinc 2 (via carbamate group) (By similarity). 
METAL   177   177        Zinc 2 (By similarity). 
METAL   230   230        Zinc 2 (By similarity). 
METAL   303   303        Zinc 1 (By similarity). 
MOD_RES   140   140        N6-carboxylysine (By similarity). 
Sequence information
Length: 426 AA [This is the length of the unprocessed precursor] Molecular weight: 46201 Da [This is the MW of the unprocessed precursor] CRC64: D8591D40D111FED3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MYVLKNGQVL NESGELENKD VLIQNGKVNL IADSIEVTSG EEFDATGKLI APGFIDVHVH 

        70         80         90        100        110        120 
LREPGGEHKE TILTGTKAAA RGGYTTICSM PNTKPVPDSK EVMNSLQAKI KETAEVRVLP 

       130        140        150        160        170        180 
YASITTSLGT DELVDFEALK EAGAFAFTDD GVGVQLAGTM YEAMKRAAAL DMAIVAHCED 

       190        200        210        220        230        240 
NSLIYGGVVH DGIFAEKEGL KGIPNIAESV QIARDVLLAE AAGCHYHVCH ISTKESVRVV 

       250        260        270        280        290        300 
RDAKRAGIRV TAEVSPHHLI LDEEDIPGND GNWKMNPPLR SKEDRAALLE GLLDGTIDFI 

       310        320        330        340        350        360 
ATDHAPHAAE EKNVPMEQAA FGIVGLETAF PLLYTHFVKT NEWTLKQLID WMTVKPAECF 

       370        380        390        400        410        420 
KLPYGKLEEG AVADIVVLDL EKEATIDPAT FYSKGKNTPF VGETCIGWPV ATFAEGELVY 


NEGENK
Q92AH1 in FASTA format

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