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UniProtKB/Swiss-Prot entry Q92997


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DVL3_HUMAN
Primary accession number Q92997
Secondary accession numbers O14642 Q13531 Q8N5E9 Q92607
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on May 30, 2000 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 86)
Name and origin of the protein
Protein name Segment polarity protein dishevelled homolog DVL-3
Synonyms Dishevelled-3
DSH homolog 3
Gene name
Name: DVL3
Synonyms: KIAA0208
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1093/hmg/5.7.953; PubMed=8817329 [NCBI, ExPASy, EBI, Israel, Japan]
Pizzuti A., Amati F., Calabrese G., Mari A., Colosimo A., Silani V., Giardino L., Ratti A., Penso D., Calza L., Palka G., Scarlato G., Novelli G., Dallapiccola B.;
"cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.";
Hum. Mol. Genet. 5:953-958(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1006/bbrc.1997.7500; PubMed=9344861 [NCBI, ExPASy, EBI, Israel, Japan]
Bui T.D., Beier D.R., Jonssen M., Smith K., Dorrington S.M., Kaklamanis L., Kearney L., Regan R., Sussman D.J., Harris A.L.;
"cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.";
Biochem. Biophys. Res. Commun. 239:510-516(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/geno.1997.4713; PubMed=9192851 [NCBI, ExPASy, EBI, Israel, Japan]
Semenov M.V., Snyder M.;
"Human dishevelled genes constitute a DHR-containing multigene family.";
Genomics 42:302-310(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Bone marrow;
DOI=10.1093/dnares/3.5.321; PubMed=9039502 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.;
"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.";
DNA Res. 3:321-329(1996).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-433.
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
INTERACTION WITH LRRFIP2.
DOI=10.1073/pnas.0409472102; PubMed=15677333 [NCBI, ExPASy, EBI, Israel, Japan]
Liu J., Bang A.G., Kintner C., Orth A.P., Chanda S.K., Ding S., Schultz P.G.;
"Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.";
Proc. Natl. Acad. Sci. U.S.A. 102:1927-1932(2005).
[7]
VARIANT [LARGE SCALE ANALYSIS] THR-216.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U49262; AAB47447.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U75651; AAB84228.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF006013; AAB65244.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D86963; BAA13199.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC032459; AAH32459.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00643141; -.
PIR JC5763; JC5763.
RefSeq NP_004414.3; -.
UniGene Hs.388116
3D structure databases
HSSP P51142; 1L6O. [HSSP ENTRY / PDB]
SMR Q92997; 247-335.
ModBase Q92997.
Protein-protein interaction databases
IntAct Q92997; 16.
PTM databases
PhosphoSite Q92997; -.
Organism-specific databases
GeneCards GC03P185357; -.
H-InvDB HIX0003920; -.
HGNC HGNC:3087; DVL3.
GenAtlas DVL3.
HPA CAB001712; -.
MIM 601368; gene. [NCBI / EBI]
PharmGKB PA27543; -.
HUGE KIAA0208.
Gene expression databases
ArrayExpress Q92997; -.
Bgee Q92997; -.
CleanEx HS_DVL3; -.
GermOnline ENSG00000161202; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008013; Molecular function: beta-catenin binding (inferred from physical interaction from UniProtKB).
GO:0004871; Molecular function: signal transducer activity (inferred from electronic annotation from InterPro).
GO:0007507; Biological process: heart development (traceable author statement from ProtInc).
GO:0007242; Biological process: intracellular signaling cascade (inferred from electronic annotation from InterPro).
GO:0007399; Biological process: nervous system development (traceable author statement from ProtInc).
GO:0045893; Biological process: positive regulation of transcription, DNA-dependent (inferred from direct assay from UniProtKB).
GO:0016055; Biological process: Wnt receptor signaling pathway (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR008339; Dishevell.
IPR003351; Dishevelled.
IPR008342; Dishevelled_3_C.
IPR001158; DIX.
IPR015506; Dsh.
IPR001478; PDZ/DHR/GLGF.
IPR000591; Pleckstrin/G-protein_interact.
IPR011991; Wing_hlx_DNA_bd.
Graphical view of domain structure.
Gene3D G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
PANTHER PTHR10878; Dsh; 1.
Pfam PF00610; DEP; 1.
PF02377; Dishevelled; 1.
PF00778; DIX; 1.
PF00595; PDZ; 1.
Pfam graphical view of domain structure.
PRINTS PR01760; DISHEVELLED.
PR01763; DISHEVELLED3.
ProDom PD003639; DIX; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00021; DAX; 1.
SM00049; DEP; 1.
SM00228; PDZ; 1.
SMART graphical view of domain structure.
PROSITE PS50186; DEP; 1.
PS50841; DIX; 1.
PS50106; PDZ; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q92997; -.
Genome annotation databases
Ensembl ENSG00000161202; Homo sapiens. [Contig view]
GeneID 1857; -.
KEGG hsa:1857; -.
Phylogenomic databases
HOGENOM Q92997; -.
HOVERGEN Q92997; -.
OMA Q92997; GPEHTTR.
Other
NextBio 7609; -.
SOURCE DVL3; Homo sapiens.
ProtoNet Q92997.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Developmental protein; Polymorphism; Wnt signaling pathway.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   716  716     Segment polarity protein dishevelled homolog DVL-3. PRO_0000145749
DOMAIN   1    82  82     DIX. 
DOMAIN   249   321  73     PDZ. 
DOMAIN   422   496  75     DEP. 
VARIANT   216   216  1     R -> T (in a breast cancer sample; somatic mutation). VAR_036116 
VARIANT   433   433  1     W -> L (in dbSNP:rs17853048 [NCBI]). VAR_025519 
CONFLICT   2     2        G -> D (in Ref. 1; AAB47447). 
CONFLICT   76    76        S -> Y (in Ref. 2; AAB84228). 
CONFLICT   102   102        P -> S (in Ref. 1; AAB47447). 
CONFLICT   151   151        G -> W (in Ref. 1; AAB47447). 
CONFLICT   182   182        S -> R (in Ref. 1; AAB47447). 
CONFLICT   218   218        K -> N (in Ref. 1; AAB47447). 
CONFLICT   222   222        R -> W (in Ref. 1; AAB47447). 
CONFLICT   230   230        E -> D (in Ref. 1; AAB47447). 
CONFLICT   233   233        S -> C (in Ref. 1; AAB47447). 
CONFLICT   236   236        S -> T (in Ref. 1; AAB47447). 
CONFLICT   239   239        T -> S (in Ref. 1; AAB47447). 
CONFLICT   242   242        T -> A (in Ref. 1; AAB47447). 
CONFLICT   303   303        N -> K (in Ref. 1; AAB47447). 
CONFLICT   431   431        R -> C (in Ref. 1; AAB47447). 
CONFLICT   450   450        W -> C (in Ref. 1; AAB47447). 
CONFLICT   465   465        R -> P (in Ref. 1; AAB47447). 
CONFLICT   472   472        L -> V (in Ref. 1; AAB47447). 
CONFLICT   543   543        P -> R (in Ref. 3; AAB65244). 
CONFLICT   553   554        FP -> LG (in Ref. 3; AAB65244). 
CONFLICT   629   629        A -> T (in Ref. 1; AAB47447). 
CONFLICT   633   633        S -> I (in Ref. 1; AAB47447). 
CONFLICT   682   716        PPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM -> LRAATWPQCPRN (in Ref. 4; BAA13199). 
Sequence information
Length: 716 AA [This is the length of the unprocessed precursor] Molecular weight: 78055 Da [This is the MW of the unprocessed precursor] CRC64: B1A55EBF9507D06E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD DDFGVVKEEI 

        70         80         90        100        110        120 
SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP PPMERTGGIG DSRPPSFHPH 

       130        140        150        160        170        180 
AGGGSQENLD NDTETDSLVS AQRERPRRRD GPEHATRLNG TAKGERRREP GGYDSSSTLM 

       190        200        210        220        230        240 
SSELETTSFF DSDEDDSTSR FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD 

       250        260        270        280        290        300 
STMSLNIITV TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 

       310        320        330        340        350        360 
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS EPIRPIDPAA 

       370        380        390        400        410        420 
WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER LDDFHLSIHS DMAAIVKAMA 

       430        440        450        460        470        480 
SPESGLEVRD RMWLKITIPN AFIGSDVVDW LYHNVEGFTD RREARKYASN LLKAGFIRHT 

       490        500        510        520        530        540 
VNKITFSEQC YYIFGDLCGN MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY 

       550        560        570        580        590        600 
PPPPHPYNPH PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG 

       610        620        630        640        650        660 
SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL ASSLRSHHTH PSYGPPGVPP 

       670        680        690        700        710 
LYGPPMLMMP PPPAAMGPPG APPGRDLASV PPELTASRQS FRMAMGNPSE FFVDVM 

Q92997 in FASTA format

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