[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). TISSUE=Brain; DOI=10.1006/geno.1996.0440; PubMed=8812431 [NCBI, ExPASy, EBI, Israel, Japan] Chestkov A.V., Baka I.D., Kost M.V., Georgiev G.P., Buchman V.L.; "The d4 gene family in the human genome."; Genomics 36:174-177(1996).

Comments

FUNCTION: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor.
SUBCELLULAR LOCATION: Cytoplasm (Potential). Nucleus (Potential).
ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing. Additional isoforms seem to exist.

Name 1

Isoform ID Q92782-1

This is the isoform sequence displayed in this entry.

Name 2

Isoform ID Q92782-2

Features which should be applied to build the isoform sequence: VSP_005607.
SIMILARITY: Belongs to the requiem/DPF family.
SIMILARITY: Contains 2 PHD-type zinc fingers.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U43843; AAC50685.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00216452; -.
IPI00291761; -.

RefSeq

NP_004638.2; -.

UniGene

Hs.631576

3D structure databases

HSSP

Q14839; 1MM2. [HSSP ENTRY / PDB]

ModBase

Q92782.

Protein-protein interaction databases

IntAct

Q92782; 1.

Organism-specific databases

GC19M043394; -.

HIX0015085; -.

HGNC:20225; DPF1.

601670; gene. [NCBI / EBI]

PharmGKB

PA134879894; -.

Gene expression databases

Q92782; -.

Q92782; -.

HS_DPF1; -.

ENSG00000011332; Homo sapiens.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005634;	Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005515;	Molecular function: protein binding (inferred from electronic annotation from InterPro).
GO:0008270;	Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006917;	Biological process: induction of apoptosis (traceable author statement from ProtInc).
GO:0006355;	Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0006350;	Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR019786; Zinc_finger_PHD-type_CS.
IPR001965; Znf_PHD.
IPR019787; Znf_PHD-finger.
IPR001841; Znf_RING.
Graphical view of domain structure.

Pfam

PF00628; PHD; 2.
Pfam graphical view of domain structure.

SMART

SM00249; PHD; 2.
SM00184; RING; 2.
SMART graphical view of domain structure.

PROSITE

PS01359; ZF_PHD_1; 1.
PS50016; ZF_PHD_2; 2.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSG00000011332; Homo sapiens. [Contig view]

GeneID

8193; -.

Phylogenomic databases

HOVERGEN

Q92782; -.

Other

30890; -.

DPF1; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Cytoplasm; Metal-binding; Nucleus; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 353`	`353`	`Zinc finger protein neuro-d4.`	`PRO_0000168145`
`ZN_FING`	`227 284`	`58`	`PHD-type 1.`
`ZN_FING`	`281 341`	`61`	`PHD-type 2.`
`VAR_SEQ`	`294 303`		`Missing (in isoform 2).`	`VSP_005607`

Sequence information

Length: 353 AA [This is the length of the unprocessed precursor]

Molecular weight: 39876 Da [This is the MW of the unprocessed precursor]

CRC64: 137D8310E77FB111 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MATVIPSPLS LGEDFYREAI EHCRSYNARL CAERSLRLPF LDSQTGVAQN NCYIWMEKTH 

        70         80         90        100        110        120 
RGPGLAPGQI YTYPARCWRK KRRLNILEDP RLRPCEYKID CEAPLKKEGG LPEGPVLEAL 

       130        140        150        160        170        180 
LCAETGEKKI ELKEEETIMD CQKQQLLEFP HDLEVEDLED DIPRRKNRAK GKAYGIGGLR 

       190        200        210        220        230        240 
KRQDTASLED RDKPYVCDKF YKELAWVPEA QRKHTAKKAP DGTVIPNGYC DFCLGGSKKT 

       250        260        270        280        290        300 
GCPEDLISCA DCGRSGHPSC LQFTVNMTAA VRTYRWQCIE CKSCSLCGTS ENDGASWAGL 

       310        320        330        340        350 
TPQDQLLFCD DCDRGYHMYC LSPPMAEPPE GSWSCHLCLR HLKEKASAYI TLT

Q92782 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools