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UniProtKB/Swiss-Prot entry Q92777


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SYN2_HUMAN
Primary accession number Q92777
Secondary accession number A8MY98
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on February 10, 2009 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 68)
Name and origin of the protein
Protein name Synapsin-2
Synonym Synapsin II
Gene name
Name: SYN2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB).
TISSUE=Brain;
DOI=10.1016/0378-1119(96)00234-X; PubMed=8964517 [NCBI, ExPASy, EBI, Israel, Japan]
Xie Y.;
"Cloning and sequencing analysis of a human synapsin IIb-encoding brain cDNA.";
Gene 173:289-290(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIA AND IIB).
TISSUE=Brain;
PubMed=10565545 [NCBI, ExPASy, EBI, Israel, Japan]
Porton B., Kao H.-T., Greengard P.;
"Cloning of cDNAs encoding human synapsins IIa and IIb.";
DNA Seq. 10:49-54(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04728; PubMed=16641997 [NCBI, ExPASy, EBI, Israel, Japan]
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
"The DNA sequence, annotation and analysis of human chromosome 3.";
Nature 440:1194-1198(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U40215; AAC50718.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF077671; AAC28368.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF077737; AAC33789.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC022234; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC026166; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC091492; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
IPI IPI00023302; -.
IPI00186299; -.
UniGene Hs.445503
3D structure databases
HSSP P17599; 1AUX. [HSSP ENTRY / PDB]
SMR Q92777; 112-419.
ModBase Q92777.
PTM databases
PhosphoSite Q92777; -.
Organism-specific databases
GeneCards GC03P012020; -.
H-InvDB HIX0023124; -.
HGNC HGNC:11495; SYN2.
GenAtlas SYN2.
HPA CAB009738; -.
MIM 600755; gene. [NCBI / EBI]
PharmGKB PA36277; -.
Gene expression databases
ArrayExpress Q92777; -.
Bgee Q92777; -.
CleanEx HS_SYN2; -.
Ontologies
GO
GO:0030054; Cellular component: cell junction (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0003824; Molecular function: catalytic activity (inferred from electronic annotation from InterPro).
GO:0007269; Biological process: neurotransmitter secretion (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013816; ATP_grasp_subdomain_2.
IPR001359; Synapsin.
IPR019735; Synapsin_CS.
IPR019569; Synapsin_N.
IPR019736; Synapsin_phosporylation.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
Pfam PF02078; Synapsin; 1.
PF02750; Synapsin_C; 1.
PF10581; Synapsin_N; 1.
Pfam graphical view of domain structure.
PRINTS PR01368; SYNAPSIN.
PROSITE PS00415; SYNAPSIN_1; 1.
PS00416; SYNAPSIN_2; 1.
Proteomic databases
PRIDE Q92777; -.
Genome annotation databases
Ensembl ENSG00000157152; Homo sapiens. [Contig view]
Phylogenomic databases
HOGENOM Q92777; -.
HOVERGEN Q92777; -.
Other
SOURCE SYN2; Homo sapiens.
ProtoNet Q92777.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell junction; Phosphoprotein; Synapse.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   582  582     Synapsin-2. PRO_0000183021
REGION   1    29  29     A. 
REGION   33   112  80     B; linker. 
REGION   113   420  308     C; actin-binding and synaptic-vesicle binding. 
REGION   421   457  37     G; Pro-rich linker. 
REGION   458   533  76     H; Pro/Ser-rich linker. 
REGION   534   582  49     E. 
COMPBIAS   34    42  9     Poly-Pro. 
COMPBIAS   486   496  11     Poly-Ser. 
COMPBIAS   512   516  5     Poly-Ser. 
MOD_RES   421   421        Phosphothreonine (By similarity). 
MOD_RES   425   425        Phosphoserine (By similarity). 
VAR_SEQ   458   480        GPGQPQGMQPPGKVLPPRRLPPG -> CLQYILDCNGIAVGPKQVQAS (in isoform IIb). VSP_006320
VAR_SEQ   481   582        Missing (in isoform IIb). VSP_006321
CONFLICT   34    34        A -> P (in Ref. 1 and 2; AAC28368/AAC33789). 
CONFLICT   36    36        T -> P (in Ref. 1 and 2; AAC28368/AAC33789). 
CONFLICT   61    61        T -> K (in Ref. 2; AAC28368/AAC33789). 
CONFLICT   61    61        T -> R (in Ref. 1; AAC50718). 
CONFLICT   64    64        A -> P (in Ref. 1 and 2; AAC28368/AAC33789). 
CONFLICT   70    70        P -> A (in Ref. 1; AAC50718). 
CONFLICT   71    71        P -> Q (in Ref. 1 and 2; AAC28368/AAC33789). 
CONFLICT   74    74        R -> P (in Ref. 1 and 2; AAC28368/AAC33789). 
CONFLICT   82    82        L -> F (in Ref. 1 and 2; AAC28368/AAC33789). 
CONFLICT   104   105        GA -> AP (in Ref. 1 and 2; AAC28368/AAC33789). 
Sequence information
Length: 582 AA [This is the length of the unprocessed precursor] Molecular weight: 62847 Da [This is the MW of the unprocessed precursor] CRC64: 70BB0F77CCF9B1E1 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQAPTPPPP GPGAASASAA PPTASPGPER 

        70         80         90        100        110        120 
TPPAASAPAP PPARTPSVGS SLFSSLSQAV KQTAASAGLV DAPGAAPAAA RKAKVLLVVD 

       130        140        150        160        170        180 
EPHADWAKCF RGKKVLGDYD IKVEQAEFSE LNLVAHADGT YAVDMQVLRN GTKVVRSFRP 

       190        200        210        220        230        240 
DFVLIRQHAF GMAENEDFRH LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG 

       250        260        270        280        290        300 
GEKFPLIEQT YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT 

       310        320        330        340        350        360 
YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS DRYKLWVDTC 

       370        380        390        400        410        420 
SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV EDRQLITELV ISKMNQLLSR 

       430        440        450        460        470        480 
TPALSPQRPL TTQQPQSGTL KDPDSSKTPP QRPPPQGGPG QPQGMQPPGK VLPPRRLPPG 

       490        500        510        520        530        540 
PSLPPSSSSS SSSSSSAPQR PGGPTTHGDA PSSSSSLAEA QPPLAAPPQK PQPHPQLNKS 

       550        560        570        580 
QSLTNAFSFS ESSFFRSSAN EDEAKAETIR SLRKSFASLF SD 

Q92777 in FASTA format

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