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UniProtKB/Swiss-Prot entry Q92058

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PPBT_CHICK
Primary accession number Q92058
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 59)
Name and origin of the protein
Protein name Alkaline phosphatase, tissue-nonspecific isozyme [Precursor]
Synonyms EC 3.1.3.1
AP-TNAP
TNSALP
Gene name
Name: ALPL
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8563025 [NCBI, ExPASy, EBI, Israel, Japan]
Crawford K., Weissig H., Binette F., Millan J.L., Goetinck P.F.;
"Tissue-nonspecific alkaline phosphatase participates in the establishment and growth of feather germs in embryonic chick skin cultures.";
Dev. Dyn. 204:48-56(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U19108; AAA92562.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Gga.760
3D structure databases
HSSP P05187; 1EW2. [HSSP ENTRY / PDB]
ModBase Q92058.
Ontologies
GO
GO:0031225; Cellular component: anchored to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004035; Molecular function: alkaline phosphatase activity (inferred from electronic annotation from EC).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR017849; Alkaline_Pase-like_a/b/a.
IPR001952; Alkaline_phosphatase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.720.10; Alk_phosphtse; 1.
Pfam PF00245; Alk_phosphatase; 1.
Pfam graphical view of domain structure.
PRINTS PR00113; ALKPHPHTASE.
SMART SM00098; alkPPc; 1.
SMART graphical view of domain structure.
PROSITE PS00123; ALKALINE_PHOSPHATASE; 1.
ProtoNet Q92058.
Genome annotation databases
Ensembl ENSGALG00000023542; Gallus gallus. [Contig view]
Phylogenomic databases
HOVERGEN Q92058; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Glycoprotein; GPI-anchor; Hydrolase; Lipoprotein; Magnesium; Membrane; Metal-binding; Phosphoprotein; Signal; Zinc.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    16  16     Potential. 
CHAIN   17   498  482     Alkaline phosphatase, tissue-nonspecific isozyme. PRO_0000024029
PROPEP   499   519  21     Removed in mature form (Potential). PRO_0000024030
ACT_SITE   109   109        Phosphoserine intermediate (By similarity). 
METAL   59    59        Magnesium (Potential). 
METAL   59    59        Zinc 2 (Potential). 
METAL   172   172        Magnesium (Potential). 
METAL   331   331        Magnesium (Potential). 
METAL   336   336        Zinc 1 (Potential). 
METAL   340   340        Zinc 1 (Potential). 
METAL   377   377        Zinc 2 (Potential). 
METAL   378   378        Zinc 2 (Potential). 
METAL   453   453        Zinc 1 (Potential). 
LIPID   498   498        GPI-anchor amidated serine (Potential). 
CARBOHYD   139   139        N-linked (GlcNAc...) (Potential). 
CARBOHYD   229   229        N-linked (GlcNAc...) (Potential). 
CARBOHYD   278   278        N-linked (GlcNAc...) (Potential). 
CARBOHYD   302   302        N-linked (GlcNAc...) (Potential). 
CARBOHYD   429   429        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 519 AA [This is the length of the unprocessed precursor] Molecular weight: 56760 Da [This is the MW of the unprocessed precursor] CRC64: 7934C0EEC3B17B89 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKAFLLTLLA QLCSASLVPE REKDPEYWRQ QAQETLRDAL RLQHLNQNVA KNLILFLGDG 

        70         80         90        100        110        120 
MGVSTVTAAR ILKGQLQHRK GEESLLEMDK FPYVALAKTY NTNAQVPDSA GTATAYLCGV 

       130        140        150        160        170        180 
KANEGTVGVS AGVTRDRCNT TKGQEVTSIL RWAKDEGKAV GIVTTTRVTH ATPSAAYAHS 

       190        200        210        220        230        240 
ANRDWYSDGE MPLDALEGGC KDIARQLVDN IPDIEVILGG GRKYMFPKNT SDVEYPQEER 

       250        260        270        280        290        300 
HRGTRLDGKD LVQAWHDTKP AGKVAKYVWH RRELLALNVS RVDFLLGLFE PGDMVYELDR 

       310        320        330        340        350        360 
NNETDPSLSE MVAVAIRMLQ KNPRGFFLLV EGGRIDHGHH EGKAKQALHE AVELDRAVGL 

       370        380        390        400        410        420 
AGRLTSPRDT LSVVTADHSH VFTFGGYTPR GNPIFGLAPM QSDVDRKPFT SILYGNGPGY 

       430        440        450        460        470        480 
KIVGGERENV SAVDFAHANY QAQAAVPLRQ ETHGGEDVAV FARGPMAHLL HGVDEQNYIP 

       490        500        510 
HAMAYAACIG PNRAHCSSAA RPAATATLLP VLLLLLLLC
Q92058 in FASTA format

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