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[1]
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NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 154-169; 172-184 AND 199-223, HOMOTETRAMERIZATION, AND TISSUE SPECIFICITY.
DOI=10.1016/S0009-2797(00)00315-X; PubMed=11306103 [NCBI, ExPASy, EBI, Israel, Japan]
Ishikura S.,
Isaji T.,
Usami N.,
Kitahara K.,
Nakagawa J.,
Hara A.;
"Molecular cloning, expression and tissue distribution of hamster diacetyl reductase. Identity with L-xylulose reductase.";
Chem. Biol. Interact. 130:879-889(2001).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], ENZYME ACTIVITY, AND TISSUE SPECIFICITY.
STRAIN=Syrian;
TISSUE=Liver;
DOI=10.1074/jbc.M110703200; PubMed=11882650 [NCBI, ExPASy, EBI, Israel, Japan]
Nakagawa J.,
Ishikura S.,
Asami J.,
Isaji T.,
Usami N.,
Hara A.,
Sakurai T.,
Tsuritani K.,
Oda K.,
Takahashi M.,
Yoshimoto M.,
Otsuka N.,
Kitamura K.;
"Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney.";
J. Biol. Chem. 277:17883-17891(2002).
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[3]
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SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1002/(SICI)1098-2795(199902)52:2<225::AID-MRD14>3.0.CO;2-M; PubMed=9890754 [NCBI, ExPASy, EBI, Israel, Japan]
Legare C.,
Berube B.,
Boue F.,
Lefievre L.,
Morales C.R.,
El-Alfy M.,
Sullivan R.;
"Hamster sperm antigen P26h is a phosphatidylinositol-anchored protein.";
Mol. Reprod. Dev. 52:225-233(1999).
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- FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
- CATALYTIC ACTIVITY: Xylitol + NADP+ = L-xylulose + NADPH.
- SUBUNIT: Homotetramer.
- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Acrosome. Note=Probably recruited to membranes via an interaction with phosphatidylinositol. During epididymal transit, it accumulates on the acrosomal cap of spermatozoa.
- TISSUE SPECIFICITY: Highly expressed in kidney and liver. Expressed in epididymis. Weakly expressed in brain, heart, lung, spleen and testis.
- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 244 AA [This is the length of the unprocessed precursor] |
Molecular weight: 25675 Da [This is the MW of the unprocessed precursor] |
CRC64: 76F7EC25BAA56D01 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MDLGLAGRRA LVTGAGKGIG RSTVLALQAA GAHVVAVSRT QADLDSLVSE CPGVETVCVD
70 80 90 100 110 120
LADWEATEQA LSSVGPVDLL VNNAAVALLQ PFLEVTKEAF DMSFNVNLRA VIQVSQIVAR
130 140 150 160 170 180
GMIARGAPGA IVNVSSQASQ RALANHSVYC STKGALDMLT KMMALELGPH KIRVNAVNPT
190 200 210 220 230 240
VVMTSMGRTN WSDPHKAKVM LDRIPLGKFA EVENVVDAIL FLLSHRSNMT TGSTLPVDGG
FLVT
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Q91XV4 in FASTA format |
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