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UniProtKB/Swiss-Prot entry Q91UZ5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IMPA2_MOUSE
Primary accession number Q91UZ5
Secondary accession numbers None
Integrated into Swiss-Prot on May 10, 2005
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 53)
Name and origin of the protein
Protein name Inositol monophosphatase 2
Synonyms EC 3.1.3.25
Inositol-1(or 4)-monophosphatase 2
IMPase 2
IMP 2
Myo-inositol monophosphatase A2
Gene name
Name: Impa2
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=129/J;
DOI=10.1016/S0378-1119(01)00502-9; PubMed=11418250 [NCBI, ExPASy, EBI, Israel, Japan]
Shamir A., Sjoholt G., Ebstein R.P., Agam G., Steen V.M.;
"Characterization of two genes, Impa1 and Impa2 encoding mouse myo-inositol monophosphatases.";
Gene 271:285-291(2001).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF353730; AAK39516.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011093; AAH11093.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_444491.1; -.
UniGene Mm.34079
3D structure databases
HSSP P29218; 1IMF. [HSSP ENTRY / PDB]
SMR Q91UZ5; 17-283.
ModBase Q91UZ5.
Organism-specific databases
MGI MGI:2149728; Impa2.
Gene expression databases
ArrayExpress Q91UZ5; -.
CleanEx MM_IMPA2; -.
GermOnline ENSMUSG00000024525; Mus musculus.
Ontologies
GO
GO:0008934; Molecular function: inositol-1(or 4)-monophosphatase activity (inferred from electronic annotation from EC).
GO:0031403; Molecular function: lithium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006020; Biological process: inositol metabolic process (traceable author statement from MGI).
QuickGo view.
Family and domain databases
InterPro IPR000760; Inositol_P.
Graphical view of domain structure.
PANTHER PTHR20854; Inositol_P; 1.
Pfam PF00459; Inositol_P; 1.
Pfam graphical view of domain structure.
PRINTS PR00378; INOSPHPHTASE.
ProDom PD023420; Inositol_P; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00629; IMP_1; 1.
PS00630; IMP_2; 1.
ProtoNet Q91UZ5.
Genome annotation databases
Ensembl ENSMUSG00000024525; Mus musculus. [Contig view]
GeneID 114663; -.
KEGG mmu:114663; -.
Phylogenomic databases
HOVERGEN Q91UZ5; -.
Other
NextBio 368644; -.
SOURCE Impa2; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Hydrolase; Lithium; Magnesium; Metal-binding.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   290  290     Inositol monophosphatase 2. PRO_0000142521
METAL   83    83        Magnesium 1 (By similarity). 
METAL   103   103        Magnesium 1 (By similarity). 
METAL   103   103        Magnesium 2 (By similarity). 
METAL   105   105        Magnesium 1; via carbonyl oxygen (By similarity). 
METAL   106   106        Magnesium 2 (By similarity). 
METAL   233   233        Magnesium 2 (By similarity). 
Sequence information
Length: 290 AA [This is the length of the unprocessed precursor] Molecular weight: 31716 Da [This is the MW of the unprocessed precursor] CRC64: F27FDC7EB1D5A436 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKPSSEEEGE LVQGVGPWDE CFEVAVQLAL RAGQIIRKAL TEEKRVSTKT SAADLVTETD 

        70         80         90        100        110        120 
HRVEDLIVSE LRKRFPSHRF IAEEATASGA KCVLTHSPTW IIDPIDGTCN FVHRFPTVAV 

       130        140        150        160        170        180 
SIGFAVHQEL EFGVIHHCTE ERLYTGRRGQ GAFCNGQRLQ VSRETDLAKA LVLTEIGPKR 

       190        200        210        220        230        240 
DPDTLKVFLS NMERLLHAKA HGVRVIGSST LALCYLASGA ADAYYQFGLH CWDLAAATVI 

       250        260        270        280        290 
IREAGGIVID TSGGPLDLMS CRVVAAGTRE MAVLIAQALQ TINYGRDDEK
Q91UZ5 in FASTA format

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