[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Oocyte; DOI=10.1016/S0378-1119(97)00325-9; PubMed=9370292 [NCBI, ExPASy, EBI, Israel, Japan] Ladomery M.R., Lyons S., Sommerville J.; "Xenopus HDm, a maternally expressed histone deacetylase, belongs to an ancient family of acetyl-metabolizing enzymes."; Gene 198:275-280(1997).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Oocyte; NIH - Xenopus Gene Collection (XGC) project; Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
[3]	TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INTERACTION WITH RBBP4. PubMed=10381399 [NCBI, ExPASy, EBI, Israel, Japan] Ryan J., Llinas A.J., White D.A., Turner B.M., Sommerville J.; "Maternal histone deacetylase is accumulated in the nuclei of Xenopus oocytes as protein complexes with potential enzyme activity."; J. Cell Sci. 112:2441-2452(1999).

Comments

FUNCTION: Histone deacetylase that is only required during early steps of development. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
CATALYTIC ACTIVITY: Hydrolysis of an N⁶-acetyl-lysine residue of a histone to yield a deacetylated histone.
SUBUNIT: Part of a large multiprotein complex that also contains RBBP4.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Oocyte.
DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Accumulates in previtellogenic oocytes and is maintained at constant level throughout oogenesis and into early embryogenesis. Declines through gastrula to neurula. Not detectable between neurula and tailbud, nor in adult tissues other than ovary.
SIMILARITY: Belongs to the histone deacetylase family. Type 1 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X78454; CAA55211.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC081136; AAH81136.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S60381; S60381.

NP_001081491.1; -.

3D structure databases

HSSP

O67135; 1C3P. [HSSP ENTRY / PDB]

ModBase

Q91695.

Ontologies

GO:0005634;	Cellular component: nucleus (inferred from electronic annotation from InterPro).
GO:0004407;	Molecular function: histone deacetylase activity (inferred from electronic annotation from InterPro).
GO:0016575;	Biological process: histone deacetylation (inferred from electronic annotation from InterPro).
GO:0007275;	Biological process: multicellular organismal development (inferred from electronic annotation from UniProtKB-KW).
GO:0006355;	Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000286; His_deacetylse.
IPR003084; His_deacetylse_1.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.800.20; His_deacetylse; 1.

PANTHER

PTHR10625; His_deacetylse; 1.
PTHR10625:SF28; His_deacetylse_1; 1.

Pfam

PF00850; Hist_deacetyl; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF037913; His_deacetylse_1; 1.

PRINTS

PR01270; HDASUPER.
PR01271; HISDACETLASE.

ProtoNet

Q91695.

Genome annotation databases

GeneID

397868; -.

KEGG

xla:397868; -.

Phylogenomic databases

HOVERGEN

Q91695; -.

Other

LinkHub

Q91695; -.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Chromatin regulator; Developmental protein; Hydrolase; Nucleus; Repressor; Transcription; Transcription regulation.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 480`	`480`	`Probable histone deacetylase 1-A.`	`PRO_0000114691`
`REGION`	`10 321`	`312`	`Histone deacetylase.`
`COMPBIAS`	`299 302`	`4`	`Poly-Gly.`
`ACT_SITE`	`141 141`		`By similarity.`

Sequence information

Length: 480 AA [This is the length of the unprocessed precursor]

Molecular weight: 54748 Da [This is the MW of the unprocessed precursor]

CRC64: 7B831822235DADB5 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MALTLGTKKK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIFRPHKAS 

        70         80         90        100        110        120 
AEDMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSAGGSVAS 

       130        140        150        160        170        180 
AVKLNKQQTD ISVNWSGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV VYIDIDIHHG 

       190        200        210        220        230        240 
DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYALRD GIDDESYEAI 

       250        260        270        280        290        300 
FKPVMSKVME MFQPSAVVLQ CGADSLSGDR LGCFNLTIKG HAKCVEFIKT FNLPLLMLGG 

       310        320        330        340        350        360 
GGYTIRNVAR CWTYETAVAL DSEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE 

       370        380        390        400        410        420 
KIKQRLFENL RMLPHAPGVQ MQAVAEDSIH DDSGEEDEDD PDKRISIRSS DKRIACDEEF 

       430        440        450        460        470        480 
SDSEDEGEGG RKNVANFKKV KRVKTEEEKE GEDKKDVKEE EKAKDEKTDS KRVKEETKSV

Q91695 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools