ID   ACVR1_CHICK             Reviewed;         504 AA.
AC   Q90ZK6; Q9YH45;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   22-JUL-2008, entry version 43.
DE   RecName: Full=Activin receptor type-1;
DE            EC=2.7.11.30;
DE   AltName: Full=Activin receptor type I;
DE   AltName: Full=Type I TGF B receptor;
DE   Flags: Precursor;
GN   Name=ACVR1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Leghorn; TISSUE=Heart;
RA   Brames G.P., Barnett J.V.;
RL   Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Derco brown;
RA   Kuchler K.;
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: On ligand binding, forms a receptor complex consisting
CC       of two type II and two type I transmembrane serine/threonine
CC       kinases. Type II receptors phosphorylate and activate type I
CC       receptors which autophosphorylate, then bind and activate SMAD
CC       transcriptional regulators. Receptor for activin (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 GS domain.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; U38622; AAC98806.1; -; mRNA.
DR   EMBL; AJ318064; CAC39433.1; -; mRNA.
DR   RefSeq; NP_989891.1; -.
DR   UniGene; Gga.2875; -.
DR   HSSP; P36897; 1IAS.
DR   Ensembl; ENSGALG00000012551; Gallus gallus.
DR   GeneID; 395246; -.
DR   KEGG; gga:395246; -.
DR   HOVERGEN; Q90ZK6; -.
DR   InterPro; IPR000333; Activin_II_recpt.
DR   InterPro; IPR000472; Activin_rcpt.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR003605; TGF_beta_rcpt_GS.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   PRINTS; PR00653; ACTIVIN2R.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00467; GS; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane;
KW   Metal-binding; Nucleotide-binding; Receptor;
KW   Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
FT   SIGNAL        1     16       Potential.
FT   CHAIN        17    504       Activin receptor type-1.
FT                                /FTId=PRO_0000253593.
FT   TOPO_DOM     17    119       Extracellular (Potential).
FT   TRANSMEM    120    140       Potential.
FT   TOPO_DOM    141    504       Cytoplasmic (Potential).
FT   DOMAIN      173    202       GS.
FT   DOMAIN      203    497       Protein kinase.
FT   NP_BIND     209    217       ATP (By similarity).
FT   ACT_SITE    331    331       Proton acceptor (By similarity).
FT   BINDING     230    230       ATP (By similarity).
FT   CARBOHYD     94     94       N-linked (GlcNAc...) (Potential).
FT   CONFLICT    211    212       KG -> SN (in Ref. 2; AAC98806).
SQ   SEQUENCE   504 AA;  56225 MW;  C7F045D6A25A071E CRC64;
     MALPVLLLLL ALPSRSVQDE ELKLNECVCE GMSCGNGDRC QGQQCFASLS INDGAKVYQK
     GCFQVYEQGK MTCKTPPSPD QAVECCQGYL CNMNITAKLP SSKGQTLQGE AAGYSMETLI
     IVILAPVVVL VIFSVVAVLI IRRIQKNHME RLNSRDAEYG TIEGLIASNV GDSTLADLLD
     HSCTSGSGSG LPFLVQRTVA RQITLVECVG KGRYGEVWRG QWQGENVAVK IFSSRDEKSW
     FRETELYNTV LLRHENILGF IASDMTSRNS STQLWLITHY HEMGSLYDYL QLTTLDTVSC
     LRIVLSIASG LAHLHIEIFG TQGKPAISHR DLKSKNILVK KNGQCCIADL GLAVMHSQST
     NQLDVGNNPR VGTKRYMAPE VLDETIQADC FDSYKRVDIW AFGLVLWEVA RRMVSNGIVE
     DYKPPFYDLV PNDPSFEDMR KVVCVDQQRP NIPNRWFSDP TLTSLAKLMK ECWYQNPSAR
     LTALRIKKTL TKIDNSLDKL KADC
//