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UniProtKB/Swiss-Prot entry Q90922

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NET1_CHICK
Primary accession number Q90922
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 67)
Name and origin of the protein
Protein name Netrin-1 [Precursor]
Synonyms None
Gene name
Name: NTN1
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=White leghorn;
TISSUE=Embryonic brain;
DOI=10.1016/0092-8674(94)90420-0; PubMed=8062384 [NCBI, ExPASy, EBI, Israel, Japan]
Serafini T., Kennedy T.E., Galko M.J., Mirzayan C., Jessell T.M., Tessier-Lavigne M.;
"The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.";
Cell 78:409-424(1994).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L34549; AAA60369.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00570611; -.
PIR A54665; A54665.
RefSeq NP_990750.1; -.
UniGene Gga.794
3D structure databases
HSSP P02468; 1NPE. [HSSP ENTRY / PDB]
ModBase Q90922.
Protein-protein interaction databases
IntAct Q90922; 3.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005578; Cellular component: proteinaceous extracellular matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR013032; EGF-like_reg_CS.
IPR002049; EGF_laminin.
IPR008211; Laminin_N.
IPR001134; Netrin_domain.
IPR018933; Netrin_module_non-TIMP.
Graphical view of domain structure.
Pfam PF00053; Laminin_EGF; 3.
PF00055; Laminin_N; 1.
PF01759; NTR; 1.
Pfam graphical view of domain structure.
SMART SM00643; C345C; 1.
SM00180; EGF_Lam; 3.
SM00136; LamNT; 1.
SMART graphical view of domain structure.
PROSITE PS00022; EGF_1; 2.
PS01248; EGF_LAM_1; 3.
PS50027; EGF_LAM_2; 3.
PS51117; LAMININ_NTER; 1.
PS50189; NTR; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 396389; -.
KEGG gga:396389; -.
Phylogenomic databases
HOVERGEN Q90922; -.
Other
ProtoNet Q90922.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Disulfide bond; Extracellular matrix; Glycoprotein; Laminin EGF-like domain; Repeat; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    25  25     Potential. 
CHAIN   26   606  581     Netrin-1. PRO_0000017084
DOMAIN   49   286  238     Laminin N-terminal. 
DOMAIN   287   342  56     Laminin EGF-like 1. 
DOMAIN   343   405  63     Laminin EGF-like 2. 
DOMAIN   406   455  50     Laminin EGF-like 3. 
DOMAIN   474   603  130     NTR. 
MOTIF   532   534  3     Cell attachment site (Potential). 
CARBOHYD   97    97        N-linked (GlcNAc...) (Potential). 
CARBOHYD   118   118        N-linked (GlcNAc...) (Potential). 
CARBOHYD   133   133        N-linked (GlcNAc...) (Potential). 
CARBOHYD   419   419        N-linked (GlcNAc...) (Potential). 
DISULFID   121   154        By similarity. 
DISULFID   287   296        By similarity. 
DISULFID   289   306        By similarity. 
DISULFID   308   317        By similarity. 
DISULFID   320   340        By similarity. 
DISULFID   343   352        By similarity. 
DISULFID   345   370        By similarity. 
DISULFID   373   382        By similarity. 
DISULFID   385   403        By similarity. 
DISULFID   406   418        By similarity. 
DISULFID   408   425        By similarity. 
DISULFID   427   436        By similarity. 
DISULFID   439   453        By similarity. 
DISULFID   474   546        By similarity. 
DISULFID   493   603        By similarity. 
Sequence information
Length: 606 AA [This is the length of the unprocessed precursor] Molecular weight: 68127 Da [This is the MW of the unprocessed precursor] CRC64: 9BFF0E3B07A71AE1 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPRRGAEGPL ALLLAAAWLA QPLRGGYPGL NMFAVQTAQP DPCYDEHGLP RRCIPDFVNS 

        70         80         90        100        110        120 
AFGKEVKVSS TCGKPPSRYC VVTEKGEEQV RSCHLCNASD PKRAHPPSFL TDLNNPHNLT 

       130        140        150        160        170        180 
CWQSDSYVQY PHNVTLTLSL GKKFEVTYVS LQFCSPRPES MAIYKSMDYG KTWVPFQFYS 

       190        200        210        220        230        240 
TQCRKMYNKP SRAAITKQNE QEAICTDSHT DVRPLSGGLI AFSTLDGRPT AHDFDNSPVL 

       250        260        270        280        290        300 
QDWVTATDIK VTFSRLHTFG DENEDDSELA RDSYFYAVSD LQVGGRCKCN GHASRCVRDR 

       310        320        330        340        350        360 
DDNLVCDCKH NTAGPECDRC KPFHYDRPWQ RATAREANEC VACNCNLHAR RCRFNMELYK 

       370        380        390        400        410        420 
LSGRKSGGVC LNCRHNTAGR HCHYCKEGFY RDLSKPISHR KACKECDCHP VGAAGQTCNQ 

       430        440        450        460        470        480 
TTGQCPCKDG VTGITCNRCA KGYQQSRSPI APCIKIPAAP PPTAASSTEE PADCDSYCKA 

       490        500        510        520        530        540 
SKGKLKINMK KYCKKDYAVQ IHILKAEKNA DWWKFTVNII SVYKQGSNRL RRGDQTLWVH 

       550        560        570        580        590        600 
AKDIACKCPK VKPMKKYLLL GSTEDSPDQS GIIADKSSLV IQWRDTWARR LRKFQQREKK 


GKCRKA
Q90922 in FASTA format

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