[1]	NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, FUNCTION, AND INDUCTION. DOI=10.1006/dbio.1995.0015; PubMed=7589799 [NCBI, ExPASy, EBI, Israel, Japan] Stern C.D., Yu R.T., Kakizuka A., Kintner C.R., Mathews L.S., Vale W.W., Evans R.M., Umesono K.; "Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo."; Dev. Biol. 172:192-205(1995).
[2]	FUNCTION, AND DEVELOPMENTAL STAGE. DOI=10.1002/neu.1019; PubMed=11291100 [NCBI, ExPASy, EBI, Israel, Japan] Kos K., Fine L., Coulombe J.N.; "Activin type II receptors in embryonic dorsal root ganglion neurons of the chicken."; J. Neurobiol. 47:93-108(2001).
[3]	FUNCTION, AND DEVELOPMENTAL STAGE. DOI=10.1016/j.ydbio.2005.05.039; PubMed=16039645 [NCBI, ExPASy, EBI, Israel, Japan] Timmer J., Chesnutt C., Niswander L.; "The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube."; Dev. Biol. 285:1-10(2005).
[4]	TISSUE SPECIFICITY. DOI=10.1677/joe.1.06303; PubMed=16135664 [NCBI, ExPASy, EBI, Israel, Japan] Lovell T.M., Knight P.G., Gladwell R.T.; "Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle."; J. Endocrinol. 186:447-455(2005).
[5]	FUNCTION, AND TISSUE SPECIFICITY. DOI=10.1677/joe.1.06525; PubMed=16461550 [NCBI, ExPASy, EBI, Israel, Japan] Lovell T.M., Knight P.G., Gladwell R.T.; "Differential expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and activin type-I and type-II receptors in preovulatory and prehierarchical follicles of the laying hen ovary."; J. Endocrinol. 188:241-249(2006).

Comments

FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Not expressed in hen anterior pituitary during the ovulatory cycle but expressed in the ovarian follicle.
DEVELOPMENTAL STAGE: Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG).
INDUCTION: By activin.
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

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Cross-references

Sequence databases

EMBL

U31223; AAA87842.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_989648.1; -.

UniGene

Gga.764

3D structure databases

HSSP

P27038; 1BTE. [HSSP ENTRY / PDB]

SMR

Q90670; 24-117.

ModBase

Q90670.

Family and domain databases

InterPro

IPR000333; Activin_II_recpt.
IPR015768; Activin_II_recpt_C.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.

PANTHER

PTHR23255:SF10; Activin_II_recpt_C; 1.

Pfam

PF01064; Activin_recp; 1.
Pfam graphical view of domain structure.

PRINTS

PR00653; ACTIVIN2R.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q90670.

Genome annotation databases

Ensembl

ENSGALG00000006158; Gallus gallus. [Contig view]

GeneID

374213; -.

KEGG

gga:374213; -.

Phylogenomic databases

HOVERGEN

Q90670; -.

Other

ProtoNet

Q90670.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 24`	`24`	`Potential.`
`CHAIN`	`25 512`	`488`	`Activin receptor type-2B.`	`PRO_0000269546`
`TOPO_DOM`	`25 137`	`113`	`Extracellular (Potential).`
`TRANSMEM`	`138 158`	`21`	`Potential.`
`TOPO_DOM`	`159 512`	`354`	`Cytoplasmic (Potential).`
`DOMAIN`	`190 478`	`289`	`Protein kinase.`
`NP_BIND`	`196 204`	`9`	`ATP (By similarity).`
`COMPBIAS`	`128 133`	`6`	`Poly-Pro.`
`COMPBIAS`	`176 183`	`8`	`Poly-Pro.`
`ACT_SITE`	`321 321`		`Proton acceptor (By similarity).`
`BINDING`	`217 217`		`ATP (By similarity).`
`CARBOHYD`	`42 42`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`65 65`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`29 59`		`By similarity.`
`DISULFID`	`49 77`		`By similarity.`
`DISULFID`	`84 103`		`By similarity.`
`DISULFID`	`90 102`		`By similarity.`
`DISULFID`	`104 109`		`By similarity.`

Sequence information

Length: 512 AA [This is the length of the unprocessed precursor]

Molecular weight: 57776 Da [This is the MW of the unprocessed precursor]

CRC64: 6051F0CBE94AE060 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSASWLTLAV LCATLGAGPG HGEAETRECI YYNANWELEK TNQSGVERCE GEKDKRLHCY 

        70         80         90        100        110        120 
ASWRNNSGSI ELVKKGCWLD DFNCYDRQEC VATEENPQVF FCCCEGNYCN EKFTHLPEVT 

       130        140        150        160        170        180 
GPEVIYEPPP PTPSLLNILV YSLLPIAVLS VAILLAFWMY RHRKPPYGHV DINEDPGPPP 

       190        200        210        220        230        240 
PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDYVAVKIFP IQDKQSWQSE REIFNTPGMK 

       250        260        270        280        290        300 
HENLLQFIAA EKRGTNLETE LWLITAFHDK GSLTDYLKGN IISWNELCHV AETMARGLSY 

       310        320        330        340        350        360 
LHEDVPWCKG EGHKPAIAHR DFKSKNVLLK NDLTAVLADF GLAVRFEPGK PPGDTHGQVG 

       370        380        390        400        410        420 
TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC RAVDGPVDEY MLPFEEEIGQ 

       430        440        450        460        470        480 
HPSLEDLQEV VVHKKMRPVF KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERIAQ 

       490        500        510 
IRKSVNGTTS DCLVSIVTSV TNVDLPPKES SI

Q90670 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools