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UniProtKB/Swiss-Prot entry Q8ZES9


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LCFA_YERPE
Primary accession number Q8ZES9
Secondary accession number Q0WF82
Integrated into Swiss-Prot on November 1, 2002
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 50)
Name and origin of the protein
Protein name Long-chain-fatty-acid--CoA ligase
Synonyms EC 6.2.1.3
Long-chain acyl-CoA synthetase
Gene name
Name: fadD
OrderedLocusNames: YPO2074, y2236, YP_1917
From
Yersinia pestis [TaxID: 632] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Yersinia.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CO-92 / Biovar Orientalis;
DOI=10.1038/35097083; PubMed=11586360 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
"Genome sequence of Yersinia pestis, the causative agent of plague.";
Nature 413:523-527(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=KIM5 / Biovar Mediaevalis;
DOI=10.1128/JB.184.16.4601-4611.2002; PubMed=12142430 [NCBI, ExPASy, EBI, Israel, Japan]
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
"Genome sequence of Yersinia pestis KIM.";
J. Bacteriol. 184:4601-4611(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=91001 / Biovar Mediaevalis;
DOI=10.1093/dnares/11.3.179; PubMed=15368893 [NCBI, ExPASy, EBI, Israel, Japan]
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.;
"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans.";
DNA Res. 11:179-197(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL590842; CAL20709.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE009952; AAM85796.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE017042; AAS62135.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AB0253; AB0253.
RefSeq NP_669545.1; -.
NP_993258.1; -.
3D structure databases
HSSP P08659; 1LCI. [HSSP ENTRY / PDB]
ModBase Q8ZES9.
Enzyme and pathway databases
BioCyc YPES187410:Y2236-MON; -.
YPES214092:YPO2074-MON; -.
YPES229193:YP1917-MON; -.
Ontologies
GO
GO:0016020; Cellular component: membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004467; Molecular function: long-chain-fatty-acid-CoA ligase activity (inferred from electronic annotation from EC).
GO:0006631; Biological process: fatty acid metabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000873; AMP-dep_Synth/Lig.
Graphical view of domain structure.
Pfam PF00501; AMP-binding; 1.
Pfam graphical view of domain structure.
PRINTS PR00154; AMPBINDING.
PROSITE PS00455; AMP_BINDING; 1.
ProtoNet Q8ZES9.
Genome annotation databases
GeneID 1147183; -.
2766250; -.
GenomeReviews AE009952_GR; y2236.
AE017042_GR; YP_1917.
AL590842_GR; YPO2074.
KEGG ype:YPO2074; -.
ypk:y2236; -.
ypm:YP_1917; -.
Phylogenomic databases
HOGENOM Q8ZES9; -.
Genome annotation databases
CMR Q8ZES9; YPO2074.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Fatty acid metabolism; Ligase; Lipid metabolism; Membrane; Nucleotide-binding.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   562  562     Long-chain-fatty-acid--CoA ligase. PRO_0000193130
NP_BIND   213   224  12     ATP (Probable). 
VARIANT   504   504  1     N -> K (in strain: KIM5 and 91001). 
Sequence information
Length: 562 AA [This is the length of the unprocessed precursor] Molecular weight: 62639 Da [This is the MW of the unprocessed precursor] CRC64: 812A872B3713D3FD [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEKVWLKRYP ADVPAEIDPD RYSSLIEMFE NAALRYADQP AFINMGEVMT FRKLEERSRA 

        70         80         90        100        110        120 
FAAYLQQGLG LQKGDRVALM MPNLLQYPIA LFGVLRAGMI VVNVNPLYTP RELEHQLSDS 

       130        140        150        160        170        180 
GAVAIVIVSN FAHTLEKVVF KTQVRHVILT RMGDQLSAAK GTLVNFVVKY IKRLVPKYYL 

       190        200        210        220        230        240 
PDAISFRTVL QKGRRMQYVK PDVINTDTAF LQYTGGTTGV AKGAILTHRN MQSNLEQAKA 

       250        260        270        280        290        300 
AYAPLLQPGR DLVVTALPLY HIFALTVNCL LFIELGGRSL LITNPRDIPG MVKELSRYPF 

       310        320        330        340        350        360 
TAITGVNTLF NALLNNEEFT HLDFSTLRLS VGGGMPVQKA VAEKWETLTG KHLLEGYGLT 

       370        380        390        400        410        420 
ECSPLVTGNP YDLKHYSGSI GLPVPSTDVR LRDDDGNDVE LGKPGELWVR GPQVMLGYWQ 

       430        440        450        460        470        480 
RPDATDDVLK DGWLATGDIA TMDEDGFLRI VDRKKDMILV SGFNVYPNEI EEVVALHAKV 

       490        500        510        520        530        540 
LESAVIGVPN EVSGEAVKVF VVKNDASLTP EELLTHCRRY LTGYKVPKIV EFRDELPKSN 

       550        560 
VGKILRRELR DEEVKVGTTD AA 

Q8ZES9 in FASTA format

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