ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q8ZBU2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name GSH1_YERPE
Primary accession number Q8ZBU2
Secondary accession number Q0WBZ1
Integrated into Swiss-Prot on August 30, 2002
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 52)
Name and origin of the protein
Protein name Glutamate--cysteine ligase
Synonyms EC 6.3.2.2
Gamma-glutamylcysteine synthetase
Gamma-ECS
GCS
Gene name
Name: gshA
OrderedLocusNames: YPO3301, y0887, YP_0385
From
Yersinia pestis [TaxID: 632] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Yersinia.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CO-92 / Biovar Orientalis;
DOI=10.1038/35097083; PubMed=11586360 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
"Genome sequence of Yersinia pestis, the causative agent of plague.";
Nature 413:523-527(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=KIM5 / Biovar Mediaevalis;
DOI=10.1128/JB.184.16.4601-4611.2002; PubMed=12142430 [NCBI, ExPASy, EBI, Israel, Japan]
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
"Genome sequence of Yersinia pestis KIM.";
J. Bacteriol. 184:4601-4611(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=91001 / Biovar Mediaevalis;
DOI=10.1093/dnares/11.3.179; PubMed=15368893 [NCBI, ExPASy, EBI, Israel, Japan]
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.;
"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans.";
DNA Res. 11:179-197(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL590842; CAL21892.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE009952; AAM84471.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE017042; AAS60658.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AI0400; AI0400.
RefSeq NP_668220.1; -.
NP_991781.1; -.
3D structure databases
ModBase Q8ZBU2.
Enzyme and pathway databases
BioCyc YPES187410:Y0887-MON; -.
YPES214092:YPO3301-MON; -.
YPES229193:YP0385-MON; -.
Ontologies
GO
GO:0004357; Molecular function: glutamate-cysteine ligase activity (inferred from electronic annotation from HAMAP).
GO:0006750; Biological process: glutathione biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00578; -; 1.
PBIL [Tree]
InterPro IPR007370; Glu_cys_ligase.
IPR006334; Glut_cys_ligase.
Graphical view of domain structure.
Pfam PF04262; Glu_cys_ligase; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01434; glu_cys_ligase; 1.
ProtoNet Q8ZBU2.
Genome annotation databases
GeneID 1145834; -.
2764400; -.
GenomeReviews AE009952_GR; y0887.
AE017042_GR; YP_0385.
AL590842_GR; YPO3301.
KEGG ype:YPO3301; -.
ypk:y0887; -.
ypm:YP_0385; -.
Phylogenomic databases
HOGENOM Q8ZBU2; -.
Genome annotation databases
CMR Q8ZBU2; YPO3301.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glutathione biosynthesis; Ligase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   519  519     Glutamate--cysteine ligase. PRO_0000192547
Sequence information
Length: 519 AA [This is the length of the unprocessed precursor] Molecular weight: 58471 Da [This is the MW of the unprocessed precursor] CRC64: 3B639BF12E4286A2 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MIPDVSHALT WLEAHPKALK GIRRGIERET LRVTADGHLA STGHPESLGA ALTHQWITTD 

        70         80         90        100        110        120 
FAEALLEFIT PVDGDIDHLL TFLRDIHRYT ARKLGDERMW PLSMPCFIEA EQDIELAKYG 

       130        140        150        160        170        180 
SSNIGRFKTL YREGLKNRYG ALMQTISGVH YNFSLPLEFW QAWAGVTDEQ SGKEEISAGY 

       190        200        210        220        230        240 
FRLIRNYYRF GWVIPYLFGA SPAICSSFLQ GRETALPFER NGKGMCYLPY ATSLRLSDLG 

       250        260        270        280        290        300 
YTNKSQSNLG ITFNDLHTYV DALKRAIQTP SEEYVALGLK DGDRHLQLNT NVLQIENELY 

       310        320        330        340        350        360 
APIRPKRVTR AGESPSDALL RGGIEYIEVR SLDINPFSPI GVDAVQARFL DLFLIWCVLA 

       370        380        390        400        410        420 
DAPEMSSDEL LCTRKNWDRV ILEGRKPGQT IGIGCSDSRQ PLETVGKALF ADLRRVAEVL 

       430        440        450        460        470        480 
DGSESASYQQ VCDELVASFD DPELTFSARI LKVMQEKGSG GVGLELAEHY REMLQNEPLE 

       490        500        510 
LLTEEQLSAE RDASRQRQHE LELKDKLSFE EYLALHGGQ 

Q8ZBU2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!