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UniProtKB/Swiss-Prot entry Q8Z8S4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COPA_SALTI
Primary accession number Q8Z8S4
Secondary accession numbers None
Integrated into Swiss-Prot on April 3, 2002
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    September 23, 2008 (Entry version 57)
Name and origin of the protein
Protein name Copper-exporting P-type ATPase A
Synonym EC 3.6.3.n1
Gene name
Name: copA
OrderedLocusNames: STY0544, t2362
From
Salmonella typhi [TaxID: 601] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CT18;
DOI=10.1038/35101607; PubMed=11677608 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18.";
Nature 413:848-852(2001).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700931 / Ty2;
DOI=10.1128/JB.185.7.2330-2337.2003; PubMed=12644504 [NCBI, ExPASy, EBI, Israel, Japan]
Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.;
"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18.";
J. Bacteriol. 185:2330-2337(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL627267; CAD04983.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014613; AAO69954.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_455093.1; -.
NP_806094.1; -.
3D structure databases
HSSP O32221; 1K0V. [HSSP ENTRY / PDB]
ModBase Q8Z8S4.
Enzyme and pathway databases
BioCyc SENT209261:T2362-MON; -.
SENT220341:STY0544-MON; -.
Family and domain databases
InterPro IPR006416; ATPase-IB_hvy.
IPR001757; ATPase_P.
IPR006403; ATPase_P_cat/Cu.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
IPR000695; H_ATPase.
IPR006121; HeavyMe_transpt.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00122; E1-E2_ATPase; 1.
PF00403; HMA; 2.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
PR00120; HATPASE.
TIGRFAMs TIGR01511; ATPase-IB1_Cu; 1.
TIGR01525; ATPase-IB_hvy; 1.
TIGR01494; ATPase_P-type; 2.
PROSITE PS00154; ATPASE_E1_E2; 1.
PS01047; HMA_1; 2.
PS50846; HMA_2; 2.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q8Z8S4.
Genome annotation databases
GeneID 1067370; -.
1247015; -.
GenomeReviews AL513382_GR; STY0544.
AE014613_GR; t2362.
KEGG stt:t2362; -.
sty:STY0544; -.
Phylogenomic databases
HOGENOM Q8Z8S4; -.
Genome annotation databases
CMR Q8Z8S4; STY0544.
Other
ProtoNet Q8Z8S4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell membrane; Complete proteome; Copper; Copper transport; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Repeat; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   833  832     Copper-exporting P-type ATPase A. PRO_0000046322
TRANSMEM   186   206  21     Potential. 
TRANSMEM   217   237  21     Potential. 
TRANSMEM   253   273  21     Potential. 
TRANSMEM   283   303  21     Potential. 
TRANSMEM   437   457  21     Potential. 
TRANSMEM   463   483  21     Potential. 
TRANSMEM   778   798  21     Potential. 
TRANSMEM   800   820  21     Potential. 
DOMAIN   4    65  62     HMA 1. 
DOMAIN   99   162  64     HMA 2. 
ACT_SITE   522   522        4-aspartylphosphate intermediate (Probable). 
METAL   14    14        Copper (Potential). 
METAL   17    17        Copper (Potential). 
METAL   109   109        Copper (Potential). 
METAL   112   112        Copper (Potential). 
METAL   719   719        Magnesium (By similarity). 
METAL   723   723        Magnesium (By similarity). 
CONFLICT   290   290        M -> V (in Ref. 2; AAO69954). 
Sequence information
Length: 833 AA [This is the length of the unprocessed precursor] Molecular weight: 87838 Da [This is the MW of the unprocessed precursor] CRC64: 350813001A756871 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSQTIDLTLD GLSCGHCVKR VKESLEQRPD VELADVTVTE AHVTGTASAD ALIETIKQAG 

        70         80         90        100        110        120 
YGATLSHPKA KPLTESSIPS EALAAVPHEL PVATADEESQ QLLLSGMSCA SCVTRVQHAL 

       130        140        150        160        170        180 
QSVPGVTQAR VNLAERTALV MGSASAADLV QAVEKAGYGA EAIEDDIKRR ERQQETAIAT 

       190        200        210        220        230        240 
MKRFRWQAIV ALAVGIPVMV WGMIGDNMMV TGDNRSLWLA IGLITLAVMV FAGGHFYRNA 

       250        260        270        280        290        300 
WKSLLNGTAT MDTLVALGTG VAWLYSMSVN LWPQWFPMEA RHLYYEASAM IIGLINLGHM 

       310        320        330        340        350        360 
LEARARQRSS KALEKLLDLT PPTARVVTED GEKSVPLADV QPGMLLRLTT GDRVPVDGEI 

       370        380        390        400        410        420 
TQGEAWLDEA MLTGEPIPQQ KGEGDSVHAG TVVQDGSILF RASAVGSHTT LSRIIRMVRQ 

       430        440        450        460        470        480 
AQSSKPEIGQ LADKISAVFV PVVVAIALFS AAIWYFFGPA PQIVYTLVIA TTVLIIACPC 

       490        500        510        520        530        540 
ALGLATPMSI ISGVGRAAEF GVLVRDADAL QRASTLDTLV FDKTGTLTEG KPQVVAVKTF 

       550        560        570        580        590        600 
NGVDEAQALR LAAALEQGSS HPLAHAILEK AGDDKLPQVN GFRTLRGLGV SGEAEGHQLL 

       610        620        630        640        650        660 
LGNQALLNEQ HVATDDMTAE ITAQASQGST PVLLAIDGKA AALLAVRDPL RSDSIAALER 

       670        680        690        700        710        720 
LHNAGYRLVM LTGDNPTTAN AIAKEAGIDE VIAGVLPDGK ADAIKRLQSQ GRQVAMVGDG 

       730        740        750        760        770        780 
INDAPALAQA DVGIAMGGGS DVAIETAAIT LMRHSLMGVA DALAISRATL RNMKQNLLGA 

       790        800        810        820        830 
FIYNSIGIPV AAGILWPFTG TLLNPVVAGA AMALSSITVV SNANRLLRFK PKA
Q8Z8S4 in FASTA format

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