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UniProtKB/Swiss-Prot entry Q8YXA2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_ANASP
Primary accession number Q8YXA2
Secondary accession numbers None
Integrated into Swiss-Prot on October 19, 2002
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 40)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: alr1313
From
Anabaena sp. (strain PCC 7120) [TaxID: 103690] [HAMAP proteome]
Taxonomy Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1093/dnares/8.5.205; PubMed=11759840 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M., Takazawa M., Yamada M., Yasuda M., Tabata S.;
"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120.";
DNA Res. 8:205-213(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000019; BAB73270.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AF1970; AF1970.
RefSeq NP_485356.1; -.
3D structure databases
HSSP Q56268; 1A05. [HSSP ENTRY / PDB]
ModBase Q8YXA2.
Enzyme and pathway databases
BioCyc NSP103690:ALR1313-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01033; -; 1.
PBIL [Tree]
InterPro IPR004429; 3-isopropylmalate_DHase.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF13; IPMDH; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00169; leuB; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q8YXA2.
Genome annotation databases
GeneID 1104908; -.
GenomeReviews BA000019_GR; alr1313.
KEGG ana:alr1313; -.
NMPDR fig|103690.1.peg.1623; -.
Phylogenomic databases
HOGENOM Q8YXA2; -.
Genome annotation databases
CMR Q8YXA2; alr1313.
Other
ProtoNet Q8YXA2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   362  362     3-isopropylmalate dehydrogenase. PRO_0000083628
NP_BIND   78    91  14     NAD (By similarity). 
NP_BIND   284   296  13     NAD (By similarity). 
METAL   226   226        Magnesium or manganese (By similarity). 
METAL   250   250        Magnesium or manganese (By similarity). 
METAL   254   254        Magnesium or manganese (By similarity). 
BINDING   98    98        Substrate (By similarity). 
BINDING   108   108        Substrate (By similarity). 
BINDING   136   136        Substrate (By similarity). 
BINDING   226   226        Substrate (By similarity). 
SITE   143   143  1     Important for catalysis (By similarity). 
SITE   194   194  1     Important for catalysis (By similarity). 
Sequence information
Length: 362 AA [This is the length of the unprocessed precursor] Molecular weight: 38769 Da [This is the MW of the unprocessed precursor] CRC64: E414E8BCC353E6D0 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTQNYRITLL PGDGIGPEIM AVAVDVLKVV GQQFDIQFDF QEALIGGAAI DATGEPLPSA 

        70         80         90        100        110        120 
TLDTCRHSDA VLLAAIGGYK WDSLPPHQRP EGGLLGLRAG LELFANLRPA QILPQLIDAS 

       130        140        150        160        170        180 
TLKREVVEGV DIMVVRELTG GIYFGKPRGI FTTETGEKRG VNTMVYTESE IDRIGRIAFE 

       190        200        210        220        230        240 
TARKRRGKLC SVDKANVLDV SQLWRDRITN LSQEYPDVEL SHLYVDNAAM QLVRAPKQFD 

       250        260        270        280        290        300 
TIVTGNLFGD ILSDAAAMLT GSIGMLPSAS LGASGPGVFE PVHGSAPDIA GQDKANPLAQ 

       310        320        330        340        350        360 
VLSAAMMLRY ALDQPQAADK IEQAVLQVLE QGDRTGDIIS VGMNLLGCRG MGDSLIKALA 


KS
Q8YXA2 in FASTA format

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