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UniProtKB/Swiss-Prot entry Q8YI63

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DDLB_BRUME
Primary accession number Q8YI63
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 2003
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 43)
Name and origin of the protein
Protein name D-alanine--D-alanine ligase B
Synonyms EC 6.3.2.4
D-alanylalanine synthetase B
D-Ala-D-Ala ligase B
Gene name
Name: ddlB
OrderedLocusNames: BMEI0582
From
Brucella melitensis [TaxID: 29459] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=16M / ATCC 23456 / NCTC 10094 / Biotype 1;
DOI=10.1073/pnas.221575398; PubMed=11756688 [NCBI, ExPASy, EBI, Israel, Japan]
DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R.;
"The genome sequence of the facultative intracellular pathogen Brucella melitensis.";
Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE009500; AAL51763.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AH3324; AH3324.
RefSeq NP_539499.1; -.
3D structure databases
HSSP P07862; 1IOW. [HSSP ENTRY / PDB]
ModBase Q8YI63.
Enzyme and pathway databases
BioCyc BMEL224914:BMEI0582-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008716; Molecular function: D-alanine-D-alanine ligase activity (inferred from electronic annotation from HAMAP).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00047; -; 1.
PBIL [Tree]
InterPro IPR011761; ATP-grasp.
IPR013816; ATP_grasp_subdomain_2.
IPR000291; D-Ala_lig_Van_CS.
IPR005905; D_ala_D_ala.
IPR011095; Dala_Dala_lig_C.
IPR011127; Dala_Dala_lig_N.
IPR013817; Pre-ATP_grasp.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
G3DSA:3.40.50.20; Pre-ATP_grasp; 1.
Pfam PF07478; Dala_Dala_lig_C; 1.
PF01820; Dala_Dala_lig_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01205; D_ala_D_alaTIGR; 1.
PROSITE PS50975; ATP_GRASP; 1.
PS00843; DALA_DALA_LIGASE_1; 1.
PS00844; DALA_DALA_LIGASE_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q8YI63.
Genome annotation databases
GeneID 1196293; -.
GenomeReviews AE008917_GR; BMEI0582.
KEGG bme:BMEI0582; -.
NMPDR fig|224914.1.peg.581; -.
Phylogenomic databases
HOGENOM Q8YI63; -.
Genome annotation databases
CMR Q8YI63; BMEI0582.
Other
ProtoNet Q8YI63.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   315  315     D-alanine--D-alanine ligase B. PRO_0000177795
DOMAIN   109   309  201     ATP-grasp. 
NP_BIND   135   190  56     ATP (By similarity). 
METAL   259   259        Magnesium or manganese 1 (By similarity). 
METAL   276   276        Magnesium or manganese 1 (By similarity). 
METAL   276   276        Magnesium or manganese 2 (By similarity). 
METAL   278   278        Magnesium or manganese 2 (By similarity). 
Sequence information
Length: 315 AA [This is the length of the unprocessed precursor] Molecular weight: 34269 Da [This is the MW of the unprocessed precursor] CRC64: AA15B74236EE24F8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRRGEARMTG KHVAVLMGGF SSERSVSLSS GVACATTLEE CGYRVTRIDV DRNVASILVE 

        70         80         90        100        110        120 
LKPDVVFNAL HGPFGEDGAI QGVLEYLQIP YTHSGVLASA LAMDKDRAKK VAAAAGVVVA 

       130        140        150        160        170        180 
PSRLMNRFDI GSQHPMKPPY VVKPVREGSS FGVVIVKEDQ PHPPQVIGSA DWKYGDEVMV 

       190        200        210        220        230        240 
EGYIAGRELT CAVMGDRAMD VCEIMPVGYQ FYDYDSKYVA GASTHVCPAK ILPNIYQKIQ 

       250        260        270        280        290        300 
TMALTAHRAI GCRGVSRSDF RFDDRFSEEG EVVWLEINTQ PGMTPTSLVP DIAKAAGISF 

       310 
AELLSWMVED ASCLR
Q8YI63 in FASTA format

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