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UniProtKB/Swiss-Prot entry Q8YHR9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DDLA_BRUME
Primary accession number Q8YHR9
Secondary accession numbers None
Integrated into Swiss-Prot on October 31, 2003
Sequence was last modified on October 31, 2003 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 45)
Name and origin of the protein
Protein name D-alanine--D-alanine ligase A
Synonyms EC 6.3.2.4
D-alanylalanine synthetaseA
D-Ala-D-Ala ligase A
Gene name
Name: ddlA
OrderedLocusNames: BMEI0727
From
Brucella melitensis [TaxID: 29459] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=16M / ATCC 23456 / NCTC 10094 / Biotype 1;
DOI=10.1073/pnas.221575398; PubMed=11756688 [NCBI, ExPASy, EBI, Israel, Japan]
DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R.;
"The genome sequence of the facultative intracellular pathogen Brucella melitensis.";
Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE009514; AAL51908.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AI3342; AI3342.
RefSeq NP_539644.1; -.
3D structure databases
HSSP P07862; 1IOV. [HSSP ENTRY / PDB]
ModBase Q8YHR9.
Enzyme and pathway databases
BioCyc BMEL224914:BMEI0727-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008716; Molecular function: D-alanine-D-alanine ligase activity (inferred from electronic annotation from HAMAP).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00047; -; 1.
PBIL [Tree]
InterPro IPR011761; ATP-grasp.
IPR013816; ATP_grasp_subdomain_2.
IPR000291; D-Ala_lig_Van_CS.
IPR005905; D_ala_D_ala.
IPR011095; Dala_Dala_lig_C.
IPR011127; Dala_Dala_lig_N.
IPR013817; Pre-ATP_grasp.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
G3DSA:3.40.50.20; Pre-ATP_grasp; 1.
Pfam PF07478; Dala_Dala_lig_C; 1.
PF01820; Dala_Dala_lig_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01205; D_ala_D_alaTIGR; 1.
PROSITE PS50975; ATP_GRASP; 1.
PS00843; DALA_DALA_LIGASE_1; 1.
PS00844; DALA_DALA_LIGASE_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q8YHR9.
Genome annotation databases
GeneID 1196438; -.
GenomeReviews AE008917_GR; BMEI0727.
KEGG bme:BMEI0727; -.
NMPDR fig|224914.1.peg.726; -.
Phylogenomic databases
HOGENOM Q8YHR9; -.
Genome annotation databases
CMR Q8YHR9; BMEI0727.
Other
ProtoNet Q8YHR9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   353  353     D-alanine--D-alanine ligase A. PRO_0000177794
DOMAIN   141   346  206     ATP-grasp. 
NP_BIND   169   224  56     ATP (By similarity). 
METAL   300   300        Magnesium or manganese 1 (By similarity). 
METAL   313   313        Magnesium or manganese 1 (By similarity). 
METAL   313   313        Magnesium or manganese 2 (By similarity). 
METAL   315   315        Magnesium or manganese 2 (By similarity). 
Sequence information
Length: 353 AA [This is the length of the unprocessed precursor] Molecular weight: 37574 Da [This is the MW of the unprocessed precursor] CRC64: 058DAEA09A676155 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MASGKMRIVV LFGGRSAEHD VSVLSATNVM NALDPAKYEA VPVFVTRAGQ WLLSRFVNGA 

        70         80         90        100        110        120 
LEKPSSGAEL CLVPGGCGRA IVVPDAGAPY EADKIDIIFP VLHGLHGEDG AVQGLAQVAR 

       130        140        150        160        170        180 
VPLAGCGIPG SANALDKDIA KRLVNEAGLS TAKSVTITRE EVPAFSALEQ ALGLPIFIKP 

       190        200        210        220        230        240 
ARQGSSVGVH KVVTEADYQA AMSDGFIYDD KLLAEEFIQA REVECGVLED EGGALFVSRA 

       250        260        270        280        290        300 
GEIVPAESHC FYSYDAKYID ADGTEIKVPA ELPEQVENEI RAIAAKAFRV LGCDSMARVD 

       310        320        330        340        350 
FFVTADRRIV LNEINTIPGF TDMSMYFKVM AVSGVSYPEI INRLVAHGLA RGS
Q8YHR9 in FASTA format

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