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UniProtKB/Swiss-Prot entry Q8WTE7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name OR1_ANOGA
Primary accession number Q8WTE7
Secondary accession numbers Q6VPM5 Q7Q1T3
Integrated into Swiss-Prot on March 1, 2004
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    June 10, 2008 (Entry version 44)
Name and origin of the protein
Protein name Odorant receptor Or1
Synonym AgOr1
Gene name
Name: OR1
ORFNames: AGAP009640
From
Anopheles gambiae (African malaria mosquito) [TaxID: 7165] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Anophelinae; Anopheles.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
STRAIN=G3;
DOI=10.1073/pnas.261432998; PubMed=11724964 [NCBI, ExPASy, EBI, Israel, Japan]
Fox A.N., Pitts R.J., Robertson H.M., Carlson J.R., Zwiebel L.J.;
"Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding.";
Proc. Natl. Acad. Sci. U.S.A. 98:14693-14697(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PEST;
DOI=10.1126/science.1076181; PubMed=12364791 [NCBI, ExPASy, EBI, Israel, Japan]
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
"The genome sequence of the malaria mosquito Anopheles gambiae.";
Science 298:129-149(2002).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-236.
STRAIN=4aRR, L3-5, and Yaounde;
PubMed=15642974 [NCBI, ExPASy, EBI, Israel, Japan]
Morlais I., Poncon N., Simard F., Cohuet A., Fontenille D.;
"Intraspecific nucleotide variation in Anopheles gambiae: new insights into the biology of malaria vectors.";
Am. J. Trop. Med. Hyg. 71:795-802(2004).
[4]
FUNCTION, AND INDUCTION.
DOI=10.1038/427212a; PubMed=14724626 [NCBI, ExPASy, EBI, Israel, Japan]
Hallem E.A., Fox A.N., Zwiebel L.J., Carlson J.R.;
"Olfaction: mosquito receptor for human-sweat odorant.";
Nature 427:212-213(2004).
[5]
IDENTIFICATION, AND TISSUE SPECIFICITY.
DOI=10.1126/science.1076196; PubMed=12364795 [NCBI, ExPASy, EBI, Israel, Japan]
Hill C.A., Fox A.N., Pitts R.J., Kent L.B., Tan P.L., Chrystal M.A., Cravchik A., Collins F.H., Robertson H.M., Zwiebel L.J.;
"G protein-coupled receptors in Anopheles gambiae.";
Science 298:176-178(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF364130; AAL35506.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAAB01008980; EAA13838.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY334005; AAR01130.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY334006; AAR01131.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY334007; AAR01132.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_318674.1; -.
3D structure databases
ModBase Q8WTE7.
Protein family/group databases
GPCRDB Q8WTE7; OR1_ANOGA.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (non-traceable author statement from UniProtKB).
GO:0005549; Molecular function: odorant binding (inferred from direct assay from UniProtKB).
GO:0004984; Molecular function: olfactory receptor activity (inferred from direct assay from UniProtKB).
GO:0042048; Biological process: olfactory behavior (inferred from direct assay from UniProtKB).
GO:0007608; Biological process: sensory perception of smell (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR004117; 7tm6_olfct_rcpt.
Graphical view of domain structure.
PANTHER PTHR21137; 7tm6_olfct_rcpt; 1.
Pfam PF02949; 7tm_6; 1.
Pfam graphical view of domain structure.
BLOCKS Q8WTE7.
Genome annotation databases
Ensembl AGAP009640; Anopheles gambiae. [Contig view]
GeneID 1279017; -.
KEGG aga:AgaP_07844; -.
VectorBase AGAP009639; Anopheles gambiae.
Phylogenomic databases
HOGENOM Q8WTE7; -.
Other
GPCRDB-Snakes Q8WTE7.
ProtoNet Q8WTE7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; G-protein coupled receptor; Membrane; Olfaction; Receptor; Sensory transduction; Transducer; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   417  417     Odorant receptor Or1. PRO_0000174286
TOPO_DOM   1     2  2     Extracellular (Potential). 
TRANSMEM   3    23  21     1 (Potential). 
TOPO_DOM   24    45  22     Cytoplasmic (Potential). 
TRANSMEM   46    66  21     2 (Potential). 
TOPO_DOM   67    73  7     Extracellular (Potential). 
TRANSMEM   74    94  21     3 (Potential). 
TOPO_DOM   95   133  39     Cytoplasmic (Potential). 
TRANSMEM   134   154  21     4 (Potential). 
TOPO_DOM   155   178  24     Extracellular (Potential). 
TRANSMEM   179   199  21     5 (Potential). 
TOPO_DOM   200   284  85     Cytoplasmic (Potential). 
TRANSMEM   285   305  21     6 (Potential). 
TOPO_DOM   306   317  12     Extracellular (Potential). 
TRANSMEM   318   338  21     7 (Potential). 
TOPO_DOM   339   417  79     Cytoplasmic (Potential). 
CONFLICT   55    55        M -> V (in Ref. 3; AAR01130/AAR01131/AAR01132). 
CONFLICT   129   129        Q -> R (in Ref. 3; AAR01130/AAR01131/AAR01132). 
CONFLICT   176   176        H -> R (in Ref. 3; AAR01130/AAR01131/AAR01132). 
Sequence information
Length: 417 AA [This is the length of the unprocessed precursor] Molecular weight: 48520 Da [This is the MW of the unprocessed precursor] CRC64: F60D7D7BD93D37F2 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKLNKLNPRW DAYDRRDSFW LQLLCLKYLG LWPPEDTDQA TRNRYIAYGW ALRIMFLHLY 

        70         80         90        100        110        120 
ALTQALYFKD VKDINDIANA LFVLMTQVTL IYKLEKFNYN IARIQACLRK LNCTLYHPKQ 

       130        140        150        160        170        180 
REEFSPVLQS MSGVFWLMIF LMFVAIFTII MWVMSPAFDN ERRLPVPAWF PVDYHHSDIV 

       190        200        210        220        230        240 
YGVLFLYQTI GIVMSATYNF STDTMFSGLM LHINGQIVRL GSMVKKLGHD VPPERQLVAT 

       250        260        270        280        290        300 
DAEWKEMRKR IDHHSKVYGT MYAKVTECVL FHKDILSFGD EVQDIFQGSI FAQVCASVII 

       310        320        330        340        350        360 
ICMTLLQATG DDVTMADLLG CGFYLLVMTS QVFIFCYVGN EISYTTDKFT EFVGFSNYFK 

       370        380        390        400        410 
FDKRTSQAMI FFLQMTLKDV HIKVGSVLKV TLNLHTFLQI MKLSYSYLAV LQSMESE 

Q8WTE7 in FASTA format

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