[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
DOI=10.1038/35068589; PubMed=11260718 [NCBI, ExPASy, EBI, Israel, Japan]
Jarillo J.A.,
Capel J.,
Tang R.-H.,
Yang H.-Q.,
Alonso J.M.,
Ecker J.R.,
Cashmore A.R.;
"An Arabidopsis circadian clock component interacts with both CRY1 and phyB.";
Nature 410:487-490(2001).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
DOI=10.1105/tpc.13.12.2659; PubMed=11752379 [NCBI, ExPASy, EBI, Israel, Japan]
Schultz T.F.,
Kiyosue T.,
Yanovsky M.,
Wada M.,
Kay S.A.;
"A role for LKP2 in the circadian clock of Arabidopsis.";
Plant Cell 13:2659-2670(2001).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/45471; PubMed=10617197 [NCBI, ExPASy, EBI, Israel, Japan]
Lin X.,
Kaul S.,
Rounsley S.D.,
Shea T.P.,
Benito M.-I.,
Town C.D.,
Fujii C.Y.,
Mason T.M.,
Bowman C.L.,
Barnstead M.E.,
Feldblyum T.V.,
Buell C.R.,
Ketchum K.A.,
Lee J.J.,
Ronning C.M.,
Koo H.L.,
Moffat K.S.,
Cronin L.A.,
Shen M., ![]()
Pai G.,
Van Aken S.,
Umayam L.,
Tallon L.J.,
Gill J.E.,
Adams M.D.,
Carrera A.J.,
Creasy T.H.,
Goodman H.M.,
Somerville C.R.,
Copenhaver G.P.,
Preuss D.,
Nierman W.C.,
White O.,
Eisen J.A.,
Salzberg S.L.,
Fraser C.M.,
Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
Nature 402:761-768(1999).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K.,
Lim J.,
Dale J.M.,
Chen H.,
Shinn P.,
Palm C.J.,
Southwick A.M.,
Wu H.C.,
Kim C.J.,
Nguyen M.,
Pham P.K.,
Cheuk R.F.,
Karlin-Newmann G.,
Liu S.X.,
Lam B.,
Sakano H.,
Wu T.,
Yu G.,
Miranda M., ![]()
Quach H.L.,
Tripp M.,
Chang C.H.,
Lee J.M.,
Toriumi M.J.,
Chan M.M.,
Tang C.C.,
Onodera C.S.,
Deng J.M.,
Akiyama K.,
Ansari Y.,
Arakawa T.,
Banh J.,
Banno F.,
Bowser L.,
Brooks S.Y.,
Carninci P.,
Chao Q.,
Choy N.,
Enju A.,
Goldsmith A.D.,
Gurjal M.,
Hansen N.F.,
Hayashizaki Y.,
Johnson-Hopson C.,
Hsuan V.W.,
Iida K.,
Karnes M.,
Khan S.,
Koesema E.,
Ishida J.,
Jiang P.X.,
Jones T.,
Kawai J.,
Kamiya A.,
Meyers C.,
Nakajima M.,
Narusaka M.,
Seki M.,
Sakurai T.,
Satou M.,
Tamse R.,
Vaysberg M.,
Wallender E.K.,
Wong C.,
Yamamura Y.,
Yuan S.,
Shinozaki K.,
Davis R.W.,
Theologis A.,
Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
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[5]
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GENE FAMILY, AND NOMENCLATURE.
DOI=10.1016/S1360-1385(00)01769-6; PubMed=11077244 [NCBI, ExPASy, EBI, Israel, Japan]
Xiao W.,
Jang J.-C.;
"F-box proteins in Arabidopsis.";
Trends Plant Sci. 5:454-457(2000).
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[6]
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INTERACTION WITH SKP1A; SKP1B; SKP1C; SKP1D; SKP1E; SKP1K; SKP1N; SKP1TA; SKP1TB; ADO1; AD03; APRR1 AND APRR5, SELF-ASSOCIATION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
DOI=10.1093/jxb/erh226; PubMed=15310821 [NCBI, ExPASy, EBI, Israel, Japan]
Yasuhara M.,
Mitsui S.,
Hirano H.,
Takanabe R.,
Tokioka Y.,
Ihara N.,
Komatsu A.,
Seki M.,
Shinozaki K.,
Kiyosue T.;
"Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis.";
J. Exp. Bot. 55:2015-2027(2004).
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[7]
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INTERACTION WITH DI19 AND COL1, AND SUBCELLULAR LOCATION.
DOI=10.1093/pcp/pci144; PubMed=15937324 [NCBI, ExPASy, EBI, Israel, Japan]
Fukamatsu Y.,
Mitsui S.,
Yasuhara M.,
Tokioka Y.,
Ihara N.,
Fujita S.,
Kiyosue T.;
"Identification of LOV KELCH PROTEIN2 (LKP2)-interacting factors that can recruit LKP2 to nuclear bodies.";
Plant Cell Physiol. 46:1340-1349(2005).
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- FUNCTION: Component of E3 ubiquitin ligase complexes that plays a central role blue-light-dependent circadian cycles. Acts as a blue-light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO2) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including transition to flowering time, hypocotyl elongation, cotyledons and leaves movement rhythms. APRR1 and APRR5 seem to be substrates of the SCF(ADO1) complex.
- PATHWAY: Protein modification; protein ubiquitination.
- SUBUNIT: Self-associates. Interacts with ADO1, AD03, SKP1A/ASK1, SKP1B/ASK2, SKP1C/ASK3, SKP1D/ASK4, SKP1E/ASK5, SKP1K/ASK11, SKP1N/ASK14, SKP1TA/ASK20A, SKP1TB/ASK20B, APRR1, APRR5, DI19 and COL1.
- INTERACTION:
Q9LKL2:APRR1; NbExp=2; IntAct=EBI-1015688, EBI-618423;
Q8LFV3:DOF3.3; NbExp=3; IntAct=EBI-1015688, EBI-1536119;
Q93ZL5:DOF5.2; NbExp=3; IntAct=EBI-1015688, EBI-1536103;
Q8W1E3:DOF5.5; NbExp=1; IntAct=EBI-1015688, EBI-1536051;
Q9SQI2:GI; NbExp=2; IntAct=EBI-1015688, EBI-446380;
- SUBCELLULAR LOCATION: Nucleus.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | Q8W420-2 |
| Features which should be applied to build the isoform sequence: VSP_016048. |
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- TISSUE SPECIFICITY: Weakly expressed in seedlings, root tips, stems, leaves, flowers, young siliques, sepals and seeds.
- PTM: FMN binds covalently to cysteine after exposure to blue light and is reversed in the dark (By similarity).
- MISCELLANEOUS: 'Adagio' means slowly in Italian.
- SIMILARITY: Belongs to the ADAGIO family.
- SIMILARITY: Contains 1 F-box domain.
- SIMILARITY: Contains 5 Kelch repeats.
- SIMILARITY: Contains 1 PAC (PAS-associated C-terminal) domain.
- SIMILARITY: Contains 1 PAS (PER-ARNT-SIM) domain.
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