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UniProtKB/Swiss-Prot entry Q8VY06


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PREP2_ARATH
Primary accession number Q8VY06
Secondary accession number Q9FX91
Integrated into Swiss-Prot on September 19, 2006
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 35)
Name and origin of the protein
Protein name Presequence protease 2, chloroplastic/mitochondrial [Precursor]
Synonyms PreP 2
AtPreP2
EC 3.4.24.-
Zinc metalloprotease 2
AtZnMP2
Gene name
Name: PREP2
Synonyms: ZNMP2
OrderedLocusNames: At1g49630
ORFNames: F14J22.13
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/35048500; PubMed=11130712 [NCBI, ExPASy, EBI, Israel, Japan]
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
Nature 408:816-820(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
[3]
IDENTIFICATION BY MASS SPECTROMETRY, AND FUNCTION.
DOI=10.1074/jbc.M205500200; PubMed=12138166 [NCBI, ExPASy, EBI, Israel, Japan]
Staahl A., Moberg P., Ytterberg J., Panfilov O., Brockenhuus Von Lowenhielm H., Nilsson F., Glaser E.;
"Isolation and identification of a novel mitochondrial metalloprotease (PreP) that degrades targeting presequences in plants.";
J. Biol. Chem. 277:41931-41939(2002).
[4]
CHARACTERIZATION, IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, AND SUBCELLULAR LOCALIZATION.
DOI=10.1093/pcp/pci107; PubMed=15827031 [NCBI, ExPASy, EBI, Israel, Japan]
Bhushan S., Staahl A., Nilsson S., Lefebvre B., Seki M., Roth C., McWilliam D., Wright S.J., Liberles D.A., Shinozaki K., Bruce B.D., Boutry M., Glaser E.;
"Catalysis, subcellular localization, expression and evolution of the targeting peptides degrading protease, AtPreP2.";
Plant Cell Physiol. 46:985-996(2005).
[5]
CLEAVAGE SPECIFICITY.
DOI=10.1016/j.jmb.2005.04.023; PubMed=15893767 [NCBI, ExPASy, EBI, Israel, Japan]
Staahl A., Nilsson S., Lundberg P., Bhushan S., Biverstaahl H., Moberg P., Morisset M., Vener A., Maeler L., Langel U., Glaser E.;
"Two novel targeting peptide degrading proteases, PrePs, in mitochondria and chloroplasts, so similar and still different.";
J. Mol. Biol. 349:847-860(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AC011807; AAG13049.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY074305; AAL67002.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT004376; AAO42370.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A96533; A96533.
RefSeq NP_175386.2; -.
NP_850961.1; -.
NP_850962.1; -.
UniGene At.27723
3D structure databases
SMR Q8VY06; 99-1077.
ModBase Q8VY06.
Protein family/group databases
MEROPS M16.018; -.
Organism-specific databases
GeneFarm 2580; 225.
TAIR At1g49630; -.
Gene expression databases
ArrayExpress Q8VY06; -.
GermOnline AT1G49630; Arabidopsis thaliana.
Ontologies
GO
GO:0009507; Cellular component: chloroplast (inferred from direct assay from TAIR).
GO:0005739; Cellular component: mitochondrion (inferred from direct assay from TAIR).
GO:0051605; Biological process: protein maturation via proteolysis (inferred from direct assay from TAIR).
QuickGo view.
Family and domain databases
InterPro IPR011237; Pept_M16_core.
IPR011765; Pept_M16_N.
IPR001431; Pept_M16_Zn_BS.
IPR007863; Peptidase_M16_C.
IPR013578; Peptidase_M16C_assoc.
Graphical view of domain structure.
Gene3D G3DSA:3.30.830.10; Pept_M16_core; 1.
Pfam PF08367; M16C_assoc; 1.
PF00675; Peptidase_M16; 1.
PF05193; Peptidase_M16_C; 2.
Pfam graphical view of domain structure.
PROSITE PS00143; INSULINASE; FALSE_NEG.
BLOCKS Q8VY06.
Proteomic databases
ProMEX Q8VY06; -.
Genome annotation databases
GeneID 841387; -.
GenomeReviews CT485782_GR; AT1G49630.
KEGG ath:AT1G49630; -.
NMPDR fig|3702.1.peg.4435; -.
Other
ProtoNet Q8VY06.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chloroplast; Complete proteome; Hydrolase; Magnesium; Metal-binding; Metalloprotease; Mitochondrion; Plastid; Protease; Transit peptide; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     84  84     Chloroplast and mitochondrion (Potential). 
CHAIN   85   1080  996     Presequence protease 2, chloroplastic/mitochondrial. PRO_0000249939
ACT_SITE   164    164        Proton acceptor (By similarity). 
METAL   161    161        Zinc (By similarity). 
METAL   165    165        Zinc (By similarity). 
METAL   261    261        Zinc (By similarity). 
Sequence information
Length: 1080 AA [This is the length of the unprocessed precursor] Molecular weight: 121131 Da [This is the MW of the unprocessed precursor] CRC64: 23425D0E7376E39E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLRSLTCSST ITSTSLFFRS FRQLPRSYLS PSSSTTVVGA SGRNIRRLST LEAAGRRLFL 

        70         80         90        100        110        120 
RRGLKLLSAA SRGLNGQFSR LSIRAVATQS APSSYPGQDE AEKLGFEKVS EEFISECKSK 

       130        140        150        160        170        180 
AVLFKHKKTG CEVMSVSNDD ENKVFGIVFR TPPKDSTGIP HILEHSVLCG SRKYPMKEPF 

       190        200        210        220        230        240 
VELLKGSLHT FLNAFTYPDR TCYPVASTNK KDFYNLVDVY LDAVFFPKCV DDVHTFQQEG 

       250        260        270        280        290        300 
WHYELNDPSE DISYKGVVFN EMKGVYSQPD NILGRVTQQA LCPENTYGVD SGGDPKDIPK 

       310        320        330        340        350        360 
LTFEKFKEFH RQYYHPSNAR IWFYGDDDPV HRLRVLSEYL DMFDASPARD SSKVEPQKLF 

       370        380        390        400        410        420 
SRPRRIVEKY PAGEDGDLKK KHMVCLNWLL SDKPLDLQTQ LALGFLDHLM LGTPASPLRK 

       430        440        450        460        470        480 
ILLESGLGEA LVNSGMEDEL LQPQFSIGLK GVSDDNVQKV EELVMNTLRK LADEGFDTDA 

       490        500        510        520        530        540 
VEASMNTIEF SLRENNTGSS PRGLSLMLQS IAKWIYDMDP FEPLKYEEPL KSLKARIAEK 

       550        560        570        580        590        600 
GSKSVFSPLI EEYILNNPHC VTIEMQPDPE KASLEEAEEK SILEKVKASM TEEDLTELAR 

       610        620        630        640        650        660 
ATEELRLKQE TPDPPDALKC VPSLNLSDIP KEPIYVPTEV GDINGVKVLR NDLFTNNILY 

       670        680        690        700        710        720 
TEVVFDMGSV KHELLQLIPL FCQSLLEMGT QDLTFVQLNQ LIGRKTGGIS VYPLTSSVYG 

       730        740        750        760        770        780 
RDDPCSKIIV RGKSMVGRAE DLFNLMNCVL QEVRFTDQQR FKQFVSQSRA RMENRLRGSG 

       790        800        810        820        830        840 
QGIAAARMDA MLNVAGWMSE QMGGLSYLEF LHTLEQKVDQ DWEGISSSLE EIRRSFLSRN 

       850        860        870        880        890        900 
GCIVNMTADG KSLTNTEKYV GKFLDLLPEN PSGELVTWDA RLPLRNEAIV IPTQVNYVGK 

       910        920        930        940        950        960 
AGNIYSSGYK LDGSSYVISK HISNTWLWDR VRVSGGAYGG SCDFDSHSGV FSFLSYRDPN 

       970        980        990       1000       1010       1020 
LLKTLDIYDG TGDFLRGLDV DEDTLTKAII GTIGDVDSYQ LPDAKGYTSL LRHLLNVTDE 

      1030       1040       1050       1060       1070       1080 
ERQIRREEIL STSLKDFKEF AEAIDSVSDK GVAVAVASQE DIDAANRERS NFFEVKKAAL 

Q8VY06 in FASTA format

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