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UniProtKB/Swiss-Prot entry Q8VHC8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MA2B1_CAVPO
Primary accession number Q8VHC8
Secondary accession numbers Q8VHC6 Q8VHC7
Integrated into Swiss-Prot on January 16, 2004
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 32)
Name and origin of the protein
Protein name Lysosomal alpha-mannosidase [Precursor]
Synonyms Laman
EC 3.2.1.24
Lysosomal acid alpha-mannosidase
Mannosidase alpha class 2B member 1
Mannosidase, alpha B
Gene name
Name: MAN2B1
Synonyms: MANB
From
Cavia porcellus (Guinea pig) [TaxID: 10141] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricognathi; Caviidae; Cavia.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], VARIANT AM TRP-227, AND VARIANT ILE-55.
DOI=10.1016/S0925-4439(01)00081-3; PubMed=11959458 [NCBI, ExPASy, EBI, Israel, Japan]
Berg T., Hopwood J.J.;
"Alpha-mannosidosis in the guinea pig: cloning of the lysosomal alpha-mannosidase cDNA and identification of a missense mutation causing alpha-mannosidosis.";
Biochim. Biophys. Acta 1586:169-176(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY036153; AAL58982.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY036154; AAL58983.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY036155; AAL58984.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP Q29451; 1O7D. [HSSP ENTRY / PDB]
SMR Q8VHC8; 49-338, 599-868, 882-1003.
ModBase Q8VHC8.
Family and domain databases
InterPro IPR011682; Glyco_hydro_38_C.
IPR015341; Glyco_hydro_38_central.
IPR000602; Glyco_hydro_38_core.
Graphical view of domain structure.
Gene3D G3DSA:3.20.110.10; Glyco_hydro_38_core; 1.
Pfam PF09261; Alpha-mann_mid; 1.
PF01074; Glyco_hydro_38; 1.
PF07748; Glyco_hydro_38C; 1.
Pfam graphical view of domain structure.
BLOCKS Q8VHC8.
Phylogenomic databases
HOVERGEN Q8VHC8; -.
Other
ProtoNet Q8VHC8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Disease mutation; Glycoprotein; Glycosidase; Hydrolase; Lysosome; Metal-binding; Polymorphism; Signal; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1     47  47     Potential. 
CHAIN   48   1007  960     Lysosomal alpha-mannosidase. PRO_0000012067
ACT_SITE   194    194        Nucleophile (By similarity). 
METAL   70     70        Zinc (By similarity). 
METAL   72     72        Zinc (By similarity). 
METAL   194    194        Zinc (By similarity). 
METAL   444    444        Zinc (By similarity). 
CARBOHYD   131    131        N-linked (GlcNAc...) (Potential). 
CARBOHYD   308    308        N-linked (GlcNAc...) (Potential). 
CARBOHYD   343    343        N-linked (GlcNAc...) (Potential). 
CARBOHYD   365    365        N-linked (GlcNAc...) (Potential). 
CARBOHYD   495    495        N-linked (GlcNAc...) (Potential). 
CARBOHYD   540    540        N-linked (GlcNAc...) (Potential). 
CARBOHYD   639    639        N-linked (GlcNAc...) (Potential). 
CARBOHYD   686    686        N-linked (GlcNAc...) (Potential). 
CARBOHYD   760    760        N-linked (GlcNAc...) (Potential). 
CARBOHYD   927    927        N-linked (GlcNAc...) (Potential). 
DISULFID   53    356        By similarity. 
DISULFID   266    271        By similarity. 
DISULFID   410    470        By similarity. 
DISULFID   491    499        By similarity. 
VARIANT   55     55  1     M -> I. 
VARIANT   227    227  1     R -> W (in AM). 
Sequence information
Length: 1007 AA [This is the length of the unprocessed precursor] Molecular weight: 113184 Da [This is the MW of the unprocessed precursor] CRC64: C128EB9948A44D41 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGASVLPLGL GAGDCQSSSG RRMSACLPRT ALSFLLSLLL ATPGARAAGY ETCPMVQPGM 

        70         80         90        100        110        120 
LNVHLVAHTH DDVGWLKTVD QYYWGIHNDL QQAGVQYILD SVISALLAEP TRRFVYVEMA 

       130        140        150        160        170        180 
FFSRWWHQQT NETQEVVRRL VRQGRLEFAN GGWVMNDEAA THYGAIVDQM TLGLRFLEDT 

       190        200        210        220        230        240 
FGSDGRPRVA WHIDPFGHSR EQASLFAQMG FDGVFFGRID YQDKLVRKKR REMELVWRAS 

       250        260        270        280        290        300 
ASLKAPAADL FTGVLPNNYG PPEGLCWDVL CADPPVVDDP RSPEYNAKKL VSYFLQLATA 

       310        320        330        340        350        360 
QGRYYRTNHT VMTMGSDFQY ENANTWFKNL DKLIQLVNMQ QANGSRVHVL YSTPACYLWE 

       370        380        390        400        410        420 
LNKANLTWPV KEDDFFPYAD GPHMFWTGYF SSRPALKRYE RLSYNFLQVC NQLEAQVGPA 

       430        440        450        460        470        480 
ANVGPYGHGD SSPLNQAMAV LQHHDAVSGT SKQHVADDYA RQLAAGWGPC EVLLSNALAK 

       490        500        510        520        530        540 
LSGSKETFLF CRDLNISICP FSQTSERFQV LVYNPLGRKV DRMVRLPVRK GLFLIKDPGN 

       550        560        570        580        590        600 
NTVPSTVVEL TSSGNPELLF PALVPALGFS VYSVTRVSDQ NPQTRSQHSR PQKYSSPVLS 

       610        620        630        640        650        660 
IKNEYLRASF HPDTGLLSMI EVLDRKLTLP VNQAFFWYNA SVGDKRSSQA SGAYIFRPSQ 

       670        680        690        700        710        720 
QWPFPVSHLA RTRLVKTALV QEVHQNFTAW CSQVVRLYSG QRHLELEWTV GPIPVGDKWG 

       730        740        750        760        770        780 
KEIISRFDTP LETGGVFFTD SNGREVLERR RDYRPSWKLN QTEPVAGNYY PVNSRIYITD 

       790        800        810        820        830        840 
GKMQLTVLTD RSQGGSSMSD GSLELMVHRR LLKDDGRGVG EALQEPGSGG WVRGRHLLLL 

       850        860        870        880        890        900 
DTAREAAAEH RLLAEKELLA PQLVLAPGQG PSYHHDHHEA VPRKQFSGLR RQLPPSVRLL 

       910        920        930        940        950        960 
TLARWGPDTL LLRLEHQFAL GEDSSRNLSL PVTLDLQDLF STFTITRLQE TTLAANQLRA 

       970        980        990       1000 
SASRLKWTTE IDPISRPAVP RLDPSSITLQ PMEIRTFVAS VQWEENS
Q8VHC8 in FASTA format

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