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UniProtKB/Swiss-Prot entry Q8UI99


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_AGRT5
Primary accession number Q8UI99
Secondary accession numbers None
Integrated into Swiss-Prot on July 26, 2002
Sequence was last modified on July 26, 2002 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 43)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: Atu0399
ORFNames: AGR_C_703
From
Agrobacterium tumefaciens (strain C58 / ATCC 33970) [TaxID: 176299] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1066804; PubMed=11743193 [NCBI, ExPASy, EBI, Israel, Japan]
Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W.;
"The genome of the natural genetic engineer Agrobacterium tumefaciens C58.";
Science 294:2317-2323(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1066803; PubMed=11743194 [NCBI, ExPASy, EBI, Israel, Japan]
Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58.";
Science 294:2323-2328(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE007869; AAK86214.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AF2625; AF2625.
E97407; E97407.
RefSeq NP_353429.2; -.
3D structure databases
HSSP P05020; 1J79. [HSSP ENTRY / PDB]
ModBase Q8UI99.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00219; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004721; DHOdimr.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001237; DHOdimr; 1.
TIGRFAMs TIGR00856; pyrC_dimer; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q8UI99.
Genome annotation databases
GeneID 1132437; -.
GenomeReviews AE007869_GR; Atu0399.
KEGG atc:AGR_C_703; -.
atu:Atu0399; -.
Phylogenomic databases
HOGENOM Q8UI99; -.
Genome annotation databases
CMR Q8UI99; Atu0399.
Other
ProtoNet Q8UI99.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   345  345     Dihydroorotase. PRO_0000147202
METAL   13    13        Zinc 1 (By similarity). 
METAL   15    15        Zinc 1 (By similarity). 
METAL   99    99        Zinc 1 (via carbamate group) (By similarity). 
METAL   99    99        Zinc 2 (via carbamate group) (By similarity). 
METAL   136   136        Zinc 2 (By similarity). 
METAL   174   174        Zinc 2 (By similarity). 
METAL   247   247        Zinc 1 (By similarity). 
MOD_RES   99    99        N6-carboxylysine (By similarity). 
Sequence information
Length: 345 AA [This is the length of the unprocessed precursor] Molecular weight: 37950 Da [This is the MW of the unprocessed precursor] CRC64: CCD97B9569F1AF78 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKSLTLRRPD DWHLHLRDGA MLEGVIGDTS RHFARAIIMP NLVPPVVTTA DASAYRERIL 

        70         80         90        100        110        120 
KAIPEGDRFE PLMTLYLTED TVADDVEEGK KSGLITAVKL YPAGATTNSH GGVRDFNKAM 

       130        140        150        160        170        180 
PVLERMAKIG LPLCVHGEVT TPDVDIFDRE KAFIDTVLEP LRQRLPELKV TMEHITTRDG 

       190        200        210        220        230        240 
VDYIKSSNAN LAGSITTHHL IINRNAILVG GIKPHYYCLP VAKREEHRLA LRAAATSGDA 

       250        260        270        280        290        300 
RFFLGTDSAP HVDPLKECAC GCAGIYTSIN TMSCLAHVFE DENALDKLEA FASLNGPAWY 

       310        320        330        340 
GLAPNDETIT LVKREEAVAF PEKIETGAGP VTVFDPMFPL HWDVN 

Q8UI99 in FASTA format

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