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UniProtKB/Swiss-Prot entry Q8UC86

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DXR_AGRT5
Primary accession number Q8UC86
Secondary accession numbers None
Integrated into Swiss-Prot on August 2, 2002
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Synonyms DXP reductoisomerase
EC 1.1.1.267
1-deoxyxylulose-5-phosphate reductoisomerase
2-C-methyl-D-erythritol 4-phosphate synthase
Gene name
Name: dxr
OrderedLocusNames: Atu2612
ORFNames: AGR_C_4736
From
Agrobacterium tumefaciens (strain C58 / ATCC 33970) [TaxID: 176299] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1066804; PubMed=11743193 [NCBI, ExPASy, EBI, Israel, Japan]
Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W.;
"The genome of the natural genetic engineer Agrobacterium tumefaciens C58.";
Science 294:2317-2323(2001).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1066803; PubMed=11743194 [NCBI, ExPASy, EBI, Israel, Japan]
Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58.";
Science 294:2323-2328(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE007869; AAK88334.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AC2897; AC2897.
E97672; E97672.
RefSeq NP_355549.1; -.
3D structure databases
HSSP P45568; 1K5H. [HSSP ENTRY / PDB]
ModBase Q8UC86.
Ontologies
GO
GO:0030604; Molecular function: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity (inferred from electronic annotation from HAMAP).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0016114; Biological process: terpenoid biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00183; -; 1.
PBIL [Tree]
InterPro IPR002110; ANK.
IPR003821; DXP_reductoisomerase.
IPR013644; DXP_reductoisomerase_C.
IPR013512; DXP_reductoisomerase_N.
Graphical view of domain structure.
Pfam PF08436; DXP_redisom_C; 1.
PF02670; DXP_reductoisom; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF006205; Dxp_reductismrs; 1.
PRINTS PR01415; ANKYRIN.
TIGRFAMs TIGR00243; Dxr; 1.
ProtoNet Q8UC86.
Genome annotation databases
GeneID 1134650; -.
GenomeReviews AE007869_GR; Atu2612.
KEGG atc:AGR_C_4736; -.
atu:Atu2612; -.
Phylogenomic databases
HOGENOM Q8UC86; -.
Genome annotation databases
CMR Q8UC86; Atu2612.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Isoprene biosynthesis; Metal-binding; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   397  397     1-deoxy-D-xylulose 5-phosphate reductoisomerase. PRO_0000163595
NP_BIND   14    45  32     NADP (By similarity). 
METAL   156   156        Divalent metal cation (By similarity). 
METAL   158   158        Divalent metal cation (By similarity). 
METAL   227   227        Divalent metal cation (By similarity). 
BINDING   131   131        Substrate (By similarity). 
BINDING   158   158        Substrate (By similarity). 
BINDING   182   182        Substrate (By similarity). 
BINDING   205   205        Substrate (By similarity). 
BINDING   227   227        Substrate (By similarity). 
Sequence information
Length: 397 AA [This is the length of the unprocessed precursor] Molecular weight: 42303 Da [This is the MW of the unprocessed precursor] CRC64: 0A24C408C2D47094 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTNASEMPRK LTILGSTGSI GTNTLDVVRQ LGGRDGFEIM ALTGAGNIAL LAEQAREFGA 

        70         80         90        100        110        120 
QLAVTADDDK YEALKSALAG TGIKVAAGMA GLEEAASMDA GWVMAAIAGT PGLAPTLTAA 

       130        140        150        160        170        180 
RRGADIALAN KECLVSAGDV FLRTVKQGGG RLIPVDSEHS AIFQCLTGEY KQAVERIVLT 

       190        200        210        220        230        240 
ASGGPFRTWS RDEMSNVTAD IARAHPNWSM GLKVSIGSAS MFNKGLEMIE AKYLFDLRPD 

       250        260        270        280        290        300 
QVDVIVHPQS IIHSMVGYTD GSYIAQLGSP DMRTAISYAL TYPERGNLSV ERLDFAKLAR 

       310        320        330        340        350        360 
LDFEAPDEAR FPALRLARMA LERGGLQGAA LNAAEETAFH AFVAGGIGFL DMAEIVETVM 

       370        380        390 
DRMHDGRTAE TMDDVFSADE EARRHALELI ATKEKAA
Q8UC86 in FASTA format

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