[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1; Weiss R.B., Dunn D.M., Robb F.T., Brown J.R.; "The complete sequence of the Pyrococcus furiosus genome."; Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.
COFACTOR: Magnesium (By similarity).
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE010263; AAL81761.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_579366.1; -.

3D structure databases

HSSP

P17256; 1KVK. [HSSP ENTRY / PDB]

ModBase

Q8U0F3.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0000287;	Molecular function: magnesium ion binding (inferred from electronic annotation from HAMAP).
GO:0004496;	Molecular function: mevalonate kinase activity (inferred from electronic annotation from HAMAP).
GO:0008299;	Biological process: isoprenoid biosynthetic process (inferred from electronic annotation from InterPro).
GO:0016310;	Biological process: phosphorylation (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

HAMAP

MF_00217; -; 1.
PBIL [Tree]

InterPro

IPR006204; GHMP_kinase.
IPR013750; GHMP_kinase_C.
IPR006203; GHMP_knse_ATP_bd_CS.
IPR006205; Mev_gal_kin.
IPR006206; Mev_galkinase.
IPR014721; Ribosomal_S5_D2-type_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.

PANTHER

PTHR10457:SF4; Mev_gal_kin; 1.

Pfam

PF08544; GHMP_kinases_C; 1.
PF00288; GHMP_kinases_N; 1.
Pfam graphical view of domain structure.

PRINTS

PR00959; MEVGALKINASE.

TIGRFAMs

TIGR00549; mevalon_kin; 1.

PROSITE

PS00627; GHMP_KINASES_ATP; 1.

ProtoNet

Q8U0F3.

Genome annotation databases

1469514; -.

AE009950_GR; PF1637.

pfu:PF1637; -.

fig|186497.1.peg.1685; -.

Phylogenomic databases

HOGENOM

Q8U0F3; -.

Genome annotation databases

CMR

Q8U0F3; PF1637.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Nucleotide-binding; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 334`	`334`	`Mevalonate kinase.`	`PRO_0000156668`
`NP_BIND`	`110 120`	`11`	`ATP (Potential).`

Sequence information

Length: 334 AA [This is the length of the unprocessed precursor]

Molecular weight: 35606 Da [This is the MW of the unprocessed precursor]

CRC64: B1ABB8A1994B5083 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKVIASAPAK VILFGEHSVV YGKPAIAAAI DLRTFVEAEL IREKKIRIEA HDIKVPGLTV 

        70         80         90        100        110        120 
SFSENEIYFE TDYGKAAEVL SYVREAINLV LEEADKKNVG IKVSITSQIP VGAGLGSSAA 

       130        140        150        160        170        180 
VAVATIGAVS KLLGLELSKE EIAKMGHKTE LLVQGASSGI DPTVSAIGGF IFYEKGKFEH 

       190        200        210        220        230        240 
LPFMELPIVV GYTGSSGPTK ELVAMVRKRY EEMPELIVPI LEAMGKVVEK AKDVILSNVD 

       250        260        270        280        290        300 
KEEKFERLGV LMNINHGLLD ALGVSTKKLS ELVYAARVAG ALGAKITGAG GGGCMYALAP 

       310        320        330 
NKQREVATAI RIAGGTPMIT EISREGLKIE EVIK

Q8U0F3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools