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UniProtKB/Swiss-Prot entry Q8TSV7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HDRD_METAC
Primary accession number Q8TSV7
Secondary accession numbers None
Integrated into Swiss-Prot on January 16, 2004
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name CoB--CoM heterodisulfide reductase 2 iron-sulfur subunit D
Synonym EC 1.8.98.1
Gene name
Name: hdrD
OrderedLocusNames: MA_0688
From
Methanosarcina acetivorans [TaxID: 2214] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
DOI=10.1101/gr.223902; PubMed=11932238 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P., McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.;
"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.";
Genome Res. 12:532-542(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE010299; AAM04128.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_615648.1; -.
3D structure databases
ModBase Q8TSV7.
Enzyme and pathway databases
BioCyc MACE188937:MA0688-MON; -.
Ontologies
GO
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051912; Molecular function: CoB--CoM heterodisulfide reductase activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0015948; Biological process: methanogenesis (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR004017; Cys_rich_region.
IPR012285; Fum_reductase_C.
Graphical view of domain structure.
Gene3D G3DSA:1.10.1060.10; Fum_reductase_C; 1.
Pfam PF02754; CCG; 2.
PF00037; Fer4; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PROSITE PS00198; 4FE4S_FER_1; 2.
PS51379; 4FE4S_FER_2; 2.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q8TSV7.
Genome annotation databases
GeneID 1472580; -.
GenomeReviews AE010299_GR; MA_0688.
KEGG mac:MA0688; -.
NMPDR fig|188937.1.peg.674; -.
Phylogenomic databases
HOGENOM Q8TSV7; -.
Genome annotation databases
CMR Q8TSV7; MA_0688.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Methanogenesis; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   409  409     CoB--CoM heterodisulfide reductase 2 iron-sulfur subunit D. PRO_0000150079
DOMAIN   14    44  31     4Fe-4S ferredoxin-type 1. 
DOMAIN   81   110  30     4Fe-4S ferredoxin-type 2. 
METAL   24    24        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   27    27        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   30    30        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   34    34        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   90    90        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   93    93        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   96    96        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   100   100        Iron-sulfur 1 (4Fe-4S) (Potential). 
Sequence information
Length: 409 AA [This is the length of the unprocessed precursor] Molecular weight: 45202 Da [This is the MW of the unprocessed precursor] CRC64: 579201A5293BC83F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAKKTPSIDT KNLTAVQLME LDSCTRCGEC VKWCPTYAAS GQKPGLAPRD KILRWRQYMN 

        70         80         90        100        110        120 
KSYGLKAKLF GPTEIPQSEL EEFKDDVHGC TTCGICATVC ESGINTVELW ESLRTNLVKK 

       130        140        150        160        170        180 
GIGPFGKQGM FPKLIGQYHN PYLLDQKDRL AWVPPDVKIA DKANIVYFTG CTAGYKQLAL 

       190        200        210        220        230        240 
AFATSRVLNK LGIEFTMLGE DEWCCGSALI RTGQVHVNDV AKELAKHNVE AIKAKGATKV 

       250        260        270        280        290        300 
LYACAGCFRA SKVDWPRLLG EELPFEVVHI TEFLEDLIKK DKIKWEKSLD KTVTYHDPCH 

       310        320        330        340        350        360 
LGRHVGVFEP PRYVLSHIPG VKFVEMDRVK EFQRCCGAGG GVKAGIPDLA LSVAESRVKD 

       370        380        390        400 
ALDTNADVLS SACPFCKRNL MDGRDSLKAD IEVEDVIVLV AQALGLSVE
Q8TSV7 in FASTA format

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