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UniProtKB/Swiss-Prot entry Q8TRA5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SAHH_METAC
Primary accession number Q8TRA5
Secondary accession numbers None
Integrated into Swiss-Prot on March 25, 2003
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 45)
Name and origin of the protein
Protein name Adenosylhomocysteinase
Synonyms EC 3.3.1.1
S-adenosyl-L-homocysteine hydrolase
AdoHcyase
Gene name
Name: ahcY
OrderedLocusNames: MA_1275
From
Methanosarcina acetivorans [TaxID: 2214] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
DOI=10.1101/gr.223902; PubMed=11932238 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P., McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.;
"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.";
Genome Res. 12:532-542(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE010299; AAM04694.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_616214.1; -.
3D structure databases
HSSP P23526; 1LI4. [HSSP ENTRY / PDB]
ModBase Q8TRA5.
Enzyme and pathway databases
BioCyc MACE188937:MA1275-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004013; Molecular function: adenosylhomocysteinase activity (inferred from electronic annotation from HAMAP).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00563; -; 1.
PBIL [Tree]
InterPro IPR000043; Ad_hcy_hydrolase.
IPR015878; Ado_hCys_hydrolase_NAD-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.1480; Ad_hcy_hydrolase; 1.
PANTHER PTHR23420; Ad_hcy_hydrolase; 1.
Pfam PF05221; AdoHcyase; 1.
PF00670; AdoHcyase_NAD; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001109; Ad_hcy_hydrolase; 1.
TIGRFAMs TIGR00936; ahcY; 1.
PROSITE PS00738; ADOHCYASE_1; 1.
PS00739; ADOHCYASE_2; 1.
ProtoNet Q8TRA5.
Genome annotation databases
GeneID 1473163; -.
GenomeReviews AE010299_GR; MA_1275.
KEGG mac:MA1275; -.
NMPDR fig|188937.1.peg.1240; -.
Phylogenomic databases
HOGENOM Q8TRA5; -.
Genome annotation databases
CMR Q8TRA5; MA_1275.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Hydrolase; NAD; One-carbon metabolism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   411  411     Adenosylhomocysteinase. PRO_0000117003
REGION   173   339  167     NAD binding (By similarity). 
BINDING   121   121        Substrate (By similarity). 
BINDING   146   146        Substrate (By similarity). 
BINDING   176   176        Substrate (By similarity). 
BINDING   180   180        Substrate (By similarity). 
Sequence information
Length: 411 AA [This is the length of the unprocessed precursor] Molecular weight: 44900 Da [This is the MW of the unprocessed precursor] CRC64: C3221440430631F2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTEQELVESG NMKMEWARNH MPVIAIIREK FEKEKPLKGL KVGMALHVEA KTAVLVETLA 

        70         80         90        100        110        120 
AGGAQVAISG CNPLSTQDDV ARALDTRKNI SCFARYGCCT SEYYEAIDKV LDIEPDITID 

       130        140        150        160        170        180 
DGADLIFKLH KERTDLLPKI LGGCEETTTG VHRLHAMEKE GALKMPVIAV NDAMTKYLFD 

       190        200        210        220        230        240 
NRYGTGQSAW DGINRTTNLL VAGKNVVVGG YGWCGRGVAM RAAGLGANVI VTEVDPIRAL 

       250        260        270        280        290        300 
EARMDGYRVM RMADAARLGE IFVTTTGNRD ILTAEHFKVM PDGAVLANSG HFNVEIDMEA 

       310        320        330        340        350        360 
LTSLAKSVKT VRHNIKEYDI GDRRINVIAE GRLVNLAAGD GHPAEVMDMS FANQALCVRY 

       370        380        390        400        410 
IAENTLLNGV HGVPRGIDTY VAKLKLESMG ISIDELTSKQ ECYMTGWECG T
Q8TRA5 in FASTA format

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