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UniProtKB/Swiss-Prot entry Q8TMT1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNLI_METAC
Primary accession number Q8TMT1
Secondary accession numbers None
Integrated into Swiss-Prot on August 13, 2002
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 42)
Name and origin of the protein
Protein name DNA ligase
Synonyms EC 6.5.1.1
Polydeoxyribonucleotide synthase [ATP]
Gene name
Name: lig
OrderedLocusNames: MA_2571
From
Methanosarcina acetivorans [TaxID: 2214] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
DOI=10.1101/gr.223902; PubMed=11932238 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P., McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.;
"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.";
Genome Res. 12:532-542(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE010299; AAM05952.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_617472.1; -.
3D structure databases
ModBase Q8TMT1.
Enzyme and pathway databases
BioCyc MACE188937:MA2571-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0003910; Molecular function: DNA ligase (ATP) activity (inferred from electronic annotation from HAMAP).
GO:0006310; Biological process: DNA recombination (inferred from electronic annotation from HAMAP).
GO:0006281; Biological process: DNA repair (inferred from electronic annotation from HAMAP).
GO:0006260; Biological process: DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00407; -; 1.
PBIL [Tree]
InterPro IPR000977; DNA_ligase.
IPR012309; DNA_ligase_A_C.
IPR012310; DNA_ligase_A_M.
IPR012308; DNA_ligase_A_N.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.
Gene3D G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
Pfam PF04679; DNA_ligase_A_C; 1.
PF01068; DNA_ligase_A_M; 1.
PF04675; DNA_ligase_A_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00574; dnl1; 1.
PROSITE PS00697; DNA_LIGASE_A1; 1.
PS00333; DNA_LIGASE_A2; FALSE_NEG.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q8TMT1.
Genome annotation databases
GeneID 1474460; -.
GenomeReviews AE010299_GR; MA_2571.
KEGG mac:MA2571; -.
NMPDR fig|188937.1.peg.2498; -.
Phylogenomic databases
HOGENOM Q8TMT1; -.
Genome annotation databases
CMR Q8TMT1; MA_2571.
Other
ProtoNet Q8TMT1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   568  568     DNA ligase. PRO_0000059603
ACT_SITE   256   256        N6-AMP-lysine intermediate (By similarity). 
Sequence information
Length: 568 AA [This is the length of the unprocessed precursor] Molecular weight: 63177 Da [This is the MW of the unprocessed precursor] CRC64: 64AA8AF2BBAE1261 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTSFREFAET CQAIEKISST IETTNKVADL LKKVDVEELP LATHFIMSEV FPAWSGEQLG 

        70         80         90        100        110        120 
IGTSLLYSSL SKASGMSVRS IESLIRTTGD IGETALLILK EKRKNQVTFS SFLEEQPELS 

       130        140        150        160        170        180 
ITEVYQRFKT ASEASGKGSQ ELKIKNLQFL FNSSTPREAK YISRLALEEL RIGVGEGVVR 

       190        200        210        220        230        240 
DAIARAFSVP SDKVEHAFMV TNDLGIVAAA AKEGGIEALE SLGIEINRPI KMMLSQISPD 

       250        260        270        280        290        300 
IDADIRDMKG AAIEWKFDGA RVQIHKNGNS VTLFSRKLEN VTNSLPDLVE IIRKHVKAES 

       310        320        330        340        350        360 
AILDGEAVAV DENGKPRAFQ EILKRFRRKY DVEEKALGIP IQLNLFDIMY LNGRTLIDLP 

       370        380        390        400        410        420 
LVERRKALES CVESSVEDSK SISVDEQVIT GDLELVEKIY REALNAGHEG VMVKNPNSAY 

       430        440        450        460        470        480 
SPGKRGKNWL KKKPLMETLD LVVVGAEWGY GRRANLIGSY SVACYDPETS RFLQVGKVGT 

       490        500        510        520        530        540 
GLTDEQLKEL TEMLSGLMEG GEAGGVFAIR PKVVLEIAFE EIQKSPNYDS GFALRFPRFI 

       550        560 
RIRDDKDPEE ADTIQRIGRV YSQQLKRL 

Q8TMT1 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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