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UniProtKB/Swiss-Prot entry Q8TMD5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name THIM_METAC
Primary accession number Q8TMD5
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 2002
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 50)
Name and origin of the protein
Protein name Hydroxyethylthiazole kinase
Synonyms EC 2.7.1.50
4-methyl-5-beta-hydroxyethylthiazole kinase
Thz kinase
TH kinase
Gene name
Name: thiM
OrderedLocusNames: MA_2723
From
Methanosarcina acetivorans [TaxID: 2214] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
DOI=10.1101/gr.223902; PubMed=11932238 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P., McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.;
"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.";
Genome Res. 12:532-542(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE010299; AAM06102.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_617622.1; -.
3D structure databases
HSSP P39593; 1EKQ. [HSSP ENTRY / PDB]
ModBase Q8TMD5.
Enzyme and pathway databases
BioCyc MACE188937:MA2723-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0004417; Molecular function: hydroxyethylthiazole kinase activity (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009228; Biological process: thiamin biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
HAMAP MF_00228; -; 1.
PBIL [Tree]
InterPro IPR000417; Hyethyz_kinase.
IPR011144; Hyethyz_kinsmonf.
Graphical view of domain structure.
PANTHER PTHR20857:SF14; Hyethyz_kinase; 1.
Pfam PF02110; HK; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000513; Thz_kinase; 1.
PRINTS PR01099; HYETHTZKNASE.
TIGRFAMs TIGR00694; thiM; 1.
ProtoNet Q8TMD5.
Genome annotation databases
GeneID 1474616; -.
GenomeReviews AE010299_GR; MA_2723.
KEGG mac:MA2723; -.
NMPDR fig|188937.1.peg.2648; -.
Phylogenomic databases
HOGENOM Q8TMD5; -.
Genome annotation databases
CMR Q8TMD5; MA_2723.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Thiamine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   261  261     Hydroxyethylthiazole kinase. PRO_0000156968
METAL   89    89        Magnesium 1 (By similarity). 
METAL   121   121        Magnesium 1 (By similarity). 
BINDING   40    40        Substrate; via amide nitrogen (By similarity). 
BINDING   116   116        ATP (By similarity). 
BINDING   162   162        ATP (By similarity). 
BINDING   189   189        Substrate; via amide nitrogen (By similarity). 
Sequence information
Length: 261 AA [This is the length of the unprocessed precursor] Molecular weight: 27767 Da [This is the MW of the unprocessed precursor] CRC64: 1C119D21B4CDB056 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNEPLKTIRE TKPLIHHITN WVTIYECANM TRAFGALPVM AHAPEECADM TKISSALVLN 

        70         80         90        100        110        120 
IGTLTSEIID SMLLSAAAAN ERDIPVVLDA VGVGATKFRD EMAAKILASV HIDIIKGNYS 

       130        140        150        160        170        180 
EIAKLAGENA ETKGVEATSI DADPAKVAKA FAKAESCVVV MTGKEDIISD GDRTFIVKNG 

       190        200        210        220        230        240 
HELMGSIVGT GCMAASIVGL FAAVNRDYCD AAKDALCYFG ASGELAAAKS SGPGSFKVHL 

       250        260 
YDEVFNLSDE KVKSMKNFEE K
Q8TMD5 in FASTA format

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