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UniProtKB/Swiss-Prot entry Q8TM02

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HDRA_METAC
Primary accession number Q8TM02
Secondary accession numbers None
Integrated into Swiss-Prot on January 16, 2004
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 49)
Name and origin of the protein
Protein name CoB--CoM heterodisulfide reductase 1 iron-sulfur subunit A
Synonym EC 1.8.98.1
Gene name
Name: hdrA
OrderedLocusNames: MA_2868
From
Methanosarcina acetivorans [TaxID: 2214] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
DOI=10.1101/gr.223902; PubMed=11932238 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P., McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.;
"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.";
Genome Res. 12:532-542(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE010299; AAM06247.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_617767.1; -.
3D structure databases
HSSP P07485; 1DWL. [HSSP ENTRY / PDB]
ModBase Q8TM02.
Enzyme and pathway databases
BioCyc MACE188937:MA2868-MON; -.
Ontologies
GO
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051912; Molecular function: CoB--CoM heterodisulfide reductase activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0015948; Biological process: methanogenesis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR003813; FlpD.
IPR016040; NAD(P)-bd.
IPR001327; Pyr_OxRdtase_NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00037; Fer4; 3.
PF02662; FlpD; 1.
PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PROSITE PS00198; 4FE4S_FER_1; 2.
PS51379; 4FE4S_FER_2; 4.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q8TM02.
Genome annotation databases
GeneID 1474765; -.
GenomeReviews AE010299_GR; MA_2868.
KEGG mac:MA2868; -.
NMPDR fig|188937.1.peg.2793; -.
Phylogenomic databases
HOGENOM Q8TM02; -.
Genome annotation databases
CMR Q8TM02; MA_2868.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; Methanogenesis; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   793  793     CoB--CoM heterodisulfide reductase 1 iron-sulfur subunit A. PRO_0000150056
DOMAIN   233   264  32     4Fe-4S ferredoxin-type 1. 
DOMAIN   282   311  30     4Fe-4S ferredoxin-type 2. 
DOMAIN   571   600  30     4Fe-4S ferredoxin-type 3. 
DOMAIN   601   629  29     4Fe-4S ferredoxin-type 4. 
NP_BIND   147   170  24     FAD (Potential). 
METAL   243   243        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   246   246        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   250   250        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   254   254        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   291   291        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   294   294        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   297   297        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   301   301        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   580   580        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   583   583        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   586   586        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   590   590        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   609   609        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   612   612        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   615   615        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   619   619        Iron-sulfur 3 (4Fe-4S) (Potential). 
Sequence information
Length: 793 AA [This is the length of the unprocessed precursor] Molecular weight: 86918 Da [This is the MW of the unprocessed precursor] CRC64: 80204B5433039032 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRIGVYICHC GLNIAGVIDV SALEAMANEL EDVVLAREVQ FLCSDSGQEG IIKDIKDNKL 

        70         80         90        100        110        120 
DRVVVAACSP RLHEKTFRHV MEKAGLNPYL MEMVNIREQC SWVHADDPQM ATQKAFDLIR 

       130        140        150        160        170        180 
MGVAKARFLR ELSATNSKAS RNVLIIGGGV AGIEAALNLA EAGFPVTMVE KESTIGGKMA 

       190        200        210        220        230        240 
LMNEVFPTND CSICVLAPKM TEVQNHPNIT LYTYSEVTDI SGSVGKFHVR VKRKPRFVLE 

       250        260        270        280        290        300 
DKCKGCVDLC SGVCPVEIEN PMNYGIGKTR AIYMPIPQSV PQVVLIDPDH CVGCGLCQLA 

       310        320        330        340        350        360 
CPAEAVDYEQ KPEEIEFEAG AIIVSTGYQL FDASRKKEYG FGKYPDVITN MQLERMLNSA 

       370        380        390        400        410        420 
GPTGGRVLVP STGEPPKSVA FIQCVGSRDK TVGNEYCSRV CCMAALKNSQ MVKERYPDTD 

       430        440        450        460        470        480 
VTIHYIDIRA AGEMYEEYYT RTQEMGVDFI RGKVAEVYSG EDGRPVVRFE NTLESSVEEE 

       490        500        510        520        530        540 
AHDLVVLSTG YEPTKAAEGI GRMLNLARRP DRFFASAHPK MRPVDAPVSG VFLAGCASGP 

       550        560        570        580        590        600 
KEIQVSIAQG SACASKVMQL LGTGELEADP MGAHVDPDKC IGCRTCVEVC KFGKISIENK 

       610        620        630        640        650        660 
KAVVDEVSCY GCGDCSAACP VGAIQMRNFE NEQILAQVRE ATAHKSQCPF IVAFLCNWCS 

       670        680        690        700        710        720 
YACADLTGMS RIRYPTNIRV IRTMCSARVN PEFVLEALKG GADGVLVAGC RMDECHYIHG 

       730        740        750        760        770        780 
NFDAKKRMDI LKEVIKEIGL DPKRLRTLWI SAAEGERFSN TINEFVKELE EIGPIGSEFK 

       790 
QECAVPGVEE VTQ
Q8TM02 in FASTA format

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