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UniProtKB/Swiss-Prot entry Q8TK88

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NADE_METAC
Primary accession number Q8TK88
Secondary accession numbers None
Integrated into Swiss-Prot on November 15, 2002
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 42)
Name and origin of the protein
Protein name NH(3)-dependent NAD(+) synthetase
Synonym EC 6.3.1.5
Gene name
Name: nadE
OrderedLocusNames: MA_3526
From
Methanosarcina acetivorans [TaxID: 2214] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
DOI=10.1101/gr.223902; PubMed=11932238 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P., McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.;
"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.";
Genome Res. 12:532-542(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE010299; AAM06889.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_618409.1; -.
3D structure databases
HSSP P08164; 1KQP. [HSSP ENTRY / PDB]
ModBase Q8TK88.
Enzyme and pathway databases
BioCyc MACE188937:MA3526-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0003952; Molecular function: NAD+ synthase (glutamine-hydrolyzing) activity (inferred from electronic annotation from InterPro).
GO:0008795; Molecular function: NAD+ synthase activity (inferred from electronic annotation from EC).
GO:0009435; Biological process: NAD biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00193; -; 1.
PBIL [Tree]
InterPro IPR003694; NAD_synthase.
IPR014729; Rossmann-like_a/b/a_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
Pfam PF02540; NAD_synthase; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00552; nadE; 1.
ProtoNet Q8TK88.
Genome annotation databases
GeneID 1475420; -.
GenomeReviews AE010299_GR; MA_3526.
KEGG mac:MA3526; -.
NMPDR fig|188937.1.peg.3435; -.
Phylogenomic databases
HOGENOM Q8TK88; -.
Genome annotation databases
CMR Q8TK88; MA_3526.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Ligase; NAD; Nucleotide-binding.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   256  256     NH(3)-dependent NAD(+) synthetase. PRO_0000152223
NP_BIND   29    36  8     ATP (By similarity). 
ACT_SITE   31    31        By similarity. 
Sequence information
Length: 256 AA [This is the length of the unprocessed precursor] Molecular weight: 28295 Da [This is the MW of the unprocessed precursor] CRC64: DDAFF53CBB97B8CE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDFEKAQNRI IEFIRNETDK AGVDGAVVGI SGGIDSALTA TLTVEALGKE RVLGLHMPES 

        70         80         90        100        110        120 
SLTPAVDSED AKILADWLGI EYRTIDISGI VSAFMASIPE SESSDRLTRG NLKARTRMSL 

       130        140        150        160        170        180 
LYFHANRLNR MVVGTGNKTE ILLGYYTKYG DGGVDLEPIG GIYKTEVWEL SRRLGIPDPL 

       190        200        210        220        230        240 
ITKKPSAGLW TGQTDEAELG ISYLKVDDVL RMIEEGAEQE KILKDTGISI EQLNSVTRRI 

       250 
ERNEHKRKSP PVPELY
Q8TK88 in FASTA format

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