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UniProtKB/Swiss-Prot entry Q8TIM8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PURA2_METAC
Primary accession number Q8TIM8
Secondary accession numbers None
Integrated into Swiss-Prot on April 13, 2004
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 42)
Name and origin of the protein
Protein name Adenylosuccinate synthetase 2
Synonyms EC 6.3.4.4
IMP--aspartate ligase 2
AdSS 2
AMPSase 2
Gene name
Name: purA2
OrderedLocusNames: MA_4118
From
Methanosarcina acetivorans [TaxID: 2214] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
DOI=10.1101/gr.223902; PubMed=11932238 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P., McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.;
"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.";
Genome Res. 12:532-542(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE010299; AAM07466.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_618986.1; -.
3D structure databases
HSSP P12283; 1ADE. [HSSP ENTRY / PDB]
ModBase Q8TIM8.
Enzyme and pathway databases
BioCyc MACE188937:MA4118-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004019; Molecular function: adenylosuccinate synthase activity (inferred from electronic annotation from HAMAP).
GO:0005525; Molecular function: GTP binding (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from HAMAP).
GO:0006164; Biological process: purine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00011; -; 1.
PBIL [Tree]
InterPro IPR001114; AdlSucc_Synth.
Graphical view of domain structure.
PANTHER PTHR11846; Asucc_synthtase; 1.
Pfam PF00709; Adenylsucc_synt; 1.
Pfam graphical view of domain structure.
ProDom PD001188; Asucc_synthtase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00788; Adenylsucc_synt; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00184; purA; 1.
PROSITE PS01266; ADENYLOSUCCIN_SYN_1; 1.
PS00513; ADENYLOSUCCIN_SYN_2; FALSE_NEG.
ProtoNet Q8TIM8.
Genome annotation databases
GeneID 1476012; -.
GenomeReviews AE010299_GR; MA_4118.
KEGG mac:MA4118; -.
NMPDR fig|188937.1.peg.4012; -.
Phylogenomic databases
HOGENOM Q8TIM8; -.
Genome annotation databases
CMR Q8TIM8; MA_4118.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; GTP-binding; Ligase; Magnesium; Metal-binding; Nucleotide-binding; Purine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   424  424     Adenylosuccinate synthetase 2. PRO_0000095270
NP_BIND   11    17  7     GTP (Potential). 
ACT_SITE   138   138        By similarity. 
METAL   12    12        Magnesium (By similarity). 
METAL   39    39        Magnesium; via carbonyl oxygen (By similarity). 
Sequence information
Length: 424 AA [This is the length of the unprocessed precursor] Molecular weight: 46759 Da [This is the MW of the unprocessed precursor] CRC64: F285B7D8FD7ABB81 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MFTIITGAQF GDEGKGKIVD LLAKDYDIVA RFQGGNNAGH TVRVGDEVYK LHLIPSGILL 

        70         80         90        100        110        120 
DARVLIGPGV VLNPEVLAEE TAMFEKHGIK VDAEKLGVDA KTSIIMPYHI EMDGLREAAR 

       130        140        150        160        170        180 
KTKIGTTKRG IGYAYIDKVA RDEIRMAELV DKERFLKRLE ELAPQKEKEI EAMGGDPKIV 

       190        200        210        220        230        240 
RDPFLIQKYL ELGEQFASYV TDVSREINQA LDEGKHVMAE AAQGTHLDVI HGTQKFVTSS 

       250        260        270        280        290        300 
STIAGSACAN LGVGPTRVGN VIAIVKAYIT RVGEGPLPTE LSGELGEKIQ KAGGEFGTTT 

       310        320        330        340        350        360 
GRGRRCGWFD LPLLKKAIAL NGYTEISLTK LDVLTGLEPL RICVGYKYKG EDLDYPPELT 

       370        380        390        400        410        420 
EDLWECSPVY EDLPGWETDL TEVKAYSELP ENAQNYIKRL EELMKVPINY ISVGPGREQT 


FKKE
Q8TIM8 in FASTA format

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