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UniProtKB/Swiss-Prot entry Q8TIB9


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HDRC_METAC
Primary accession number Q8TIB9
Secondary accession numbers None
Integrated into Swiss-Prot on January 16, 2004
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name CoB--CoM heterodisulfide reductase 1 iron-sulfur subunit C
Synonym EC 1.8.98.1
Gene name
Name: hdrC
OrderedLocusNames: MA_4236
From
Methanosarcina acetivorans [TaxID: 2214] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
DOI=10.1101/gr.223902; PubMed=11932238 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P., McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.;
"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.";
Genome Res. 12:532-542(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE010299; AAM07581.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_619101.1; -.
3D structure databases
ModBase Q8TIB9.
Enzyme and pathway databases
BioCyc MACE188937:MA4236-MON; -.
Ontologies
GO
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051912; Molecular function: CoB--CoM heterodisulfide reductase activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0015948; Biological process: methanogenesis (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR017680; CoB/CoM_hetero-S_rdtase_csu.
IPR012285; Fum_reductase_C.
Graphical view of domain structure.
Gene3D G3DSA:1.10.1060.10; Fum_reductase_C; 1.
Pfam PF00037; Fer4; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PROSITE PS00198; 4FE4S_FER_1; 2.
PS51379; 4FE4S_FER_2; 2.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q8TIB9.
Genome annotation databases
GeneID 1476130; -.
GenomeReviews AE010299_GR; MA_4236.
KEGG mac:MA4236; -.
NMPDR fig|188937.1.peg.4127; -.
Phylogenomic databases
HOGENOM Q8TIB9; -.
Genome annotation databases
CMR Q8TIB9; MA_4236.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Methanogenesis; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   161  161     CoB--CoM heterodisulfide reductase 1 iron-sulfur subunit C. PRO_0000150072
DOMAIN   10    40  31     4Fe-4S ferredoxin-type 1. 
DOMAIN   51    82  32     4Fe-4S ferredoxin-type 2. 
METAL   19    19        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   22    22        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   25    25        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   29    29        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   62    62        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   65    65        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   68    68        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   72    72        Iron-sulfur 1 (4Fe-4S) (Potential). 
Sequence information
Length: 161 AA [This is the length of the unprocessed precursor] Molecular weight: 18150 Da [This is the MW of the unprocessed precursor] CRC64: 3D0339845B0DD95C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSEELLKLLK AEGLDLLSCM HCGICTGSCP SGRHTGLNTR RIIRDARKNR AAVLSDYDLW 

        70         80         90        100        110        120 
LCTTCYTCQE RCPRGIPITD AILELRRLAV REGLMLPEHR FVSEMVLECG HAVPLDEETK 

       130        140        150        160 
KKREELGLDP IPETVQKDPE ALEGLKTLLK TCKFDELVAK K 

Q8TIB9 in FASTA format

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