[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION. DOI=10.1074/jbc.M104087200; PubMed=11533052 [NCBI, ExPASy, EBI, Israel, Japan] Stromhaug P.E., Bevan A., Dunn W.A. Jr.; "GSA11 encodes a unique 208-kDa protein required for pexophagy and autophagy in Pichia pastoris."; J. Biol. Chem. 276:42422-42435(2001).
[2]	NOMENCLATURE. DOI=10.1016/S1534-5807(03)00296-X; PubMed=14536056 [NCBI, ExPASy, EBI, Israel, Japan] Klionsky D.J., Cregg J.M., Dunn W.A. Jr., Emr S.D., Sakai Y., Sandoval I.V., Sibirny A., Subramani S., Thumm M., Veenhuis M., Ohsumi Y.; "A unified nomenclature for yeast autophagy-related genes."; Dev. Cell 5:539-545(2003).

Comments

FUNCTION: Serine/threonine-protein kinase required for pexophagy and autophagy and probably involved in cytoplasm to vacuole transport (Cvt).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY075104; AAL77195.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P49137; 1NY3. [HSSP ENTRY / PDB]

ModBase

Q8TGI1.

Family and domain databases

InterPro

IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.

Pfam

PF00069; Pkinase; 1.
Pfam graphical view of domain structure.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00220; S_TKc; 1.
SMART graphical view of domain structure.

PROSITE

PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Autophagy; Cytoplasm; Kinase; Nucleotide-binding; Protein transport; Serine/threonine-protein kinase; Transferase; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 796`	`796`	`Serine/threonine-protein kinase ATG1.`	`PRO_0000085651`
`DOMAIN`	`9 304`	`296`	`Protein kinase.`
`NP_BIND`	`15 23`	`9`	`ATP (By similarity).`
`ACT_SITE`	`155 155`		`Proton acceptor (By similarity).`
`BINDING`	`38 38`		`ATP (By similarity).`

Sequence information

Length: 796 AA [This is the length of the unprocessed precursor]

Molecular weight: 90050 Da [This is the MW of the unprocessed precursor]

CRC64: 3CFAAE3FE61413FA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPDRKIGDYV VGAEIGRGSF ANVYKGYNSK TQVSVAIKSV IKSRLRNKKL IENLEVEISI 

        70         80         90        100        110        120 
LKNLKHPHVV ALLDCEQSKH YFHLLMEYCS LGDLSYFITK REELISNHPL ITGVFKKYPS 

       130        140        150        160        170        180 
PENSKGLNEV ITINFVQQLA SALKFLRSQN LVHRDIKPQN LLLSPPVSRE VFEDRKYTGL 

       190        200        210        220        230        240 
WELPVLKIAD FGFARFLPAT SMAETLCGSP LYMAPEILRY EKYNAKADLW SVGAVVYEMS 

       250        260        270        280        290        300 
VGTPPFPAHN HVELLRNIER QKDKISFPKV AQVPPEIIQL ICGLLKQQAT ERMSFQEFFN 

       310        320        330        340        350        360 
DPVITTKLQP CSDEPLLPQN QHIDENLFIS EYLPRNSITD KNINNNITNI AKNGVEEALL 

       370        380        390        400        410        420 
EEEDEEEDQD QLPSKNDNIQ HMEPDSSMLL NKTTQKQTEV QSQPRRELVS EKDYVVVEKR 

       430        440        450        460        470        480 
AVEVNALADE LEHAGSGALA MQLTNNVGTP YTRRYSSSSR SSSTGSNQRR PSFGDRKVPI 

       490        500        510        520        530        540 
SISPTNALSK AINIASNRLF KQPSPPKATP VLLEEKDKDK NTERLTSTVF NQNMLNSTTT 

       550        560        570        580        590        600 
REITRPLHSL TITSSTSDEE IIQRLSNLTT KAYAIKLLAE IKFSQLAPLP PSNETAVFDN 

       610        620        630        640        650        660 
YGDDEGTQSG YNNEPLSPIL IKTIGEEGIA LYVKTLFLLS KAMNIAMEWW RLNSLSRPAS 

       670        680        690        700        710        720 
PKLNDLVQWI RGKFNESLEK AEFIKLKLQN AKEQLEESES DTDKTVVAEK LIFDRAIEIS 

       730        740        750        760        770        780 
RIAVVNELKN DDLVGTELSY ATAIWMLEAL LEPDDTEESK LDDEDRKMIE KFISSIGNRL 

       790 
SVLRKKIEST SQETRK

Q8TGI1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools