[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION. STRAIN=ATCC 34438 / CBS 4732 / DSM 70277 / IFO 1476 / NRRL Y-5445; DOI=10.1016/S1567-1356(02)00135-6; PubMed=12702243 [NCBI, ExPASy, EBI, Israel, Japan] Komduur J.A., Veenhuis M., Kiel J.A.K.W.; "The Hansenula polymorpha PDD7 gene is essential for micropexophagy and microautophagy."; FEMS Yeast Res. 3:27-34(2003).
[2]	NOMENCLATURE. DOI=10.1016/S1534-5807(03)00296-X; PubMed=14536056 [NCBI, ExPASy, EBI, Israel, Japan] Klionsky D.J., Cregg J.M., Dunn W.A. Jr., Emr S.D., Sakai Y., Sandoval I.V., Sibirny A., Subramani S., Thumm M., Veenhuis M., Ohsumi Y.; "A unified nomenclature for yeast autophagy-related genes."; Dev. Cell 5:539-545(2003).

Comments

FUNCTION: Serine/threonine-protein kinase involved in glucose-induced peroxisome degradation (micropexophagy), ethanol-induced macropexophagy and microautophagy. Probably also involved in cytoplasm to vacuole transport (Cvt).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY053423; AAL23618.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P49137; 1NY3. [HSSP ENTRY / PDB]

ModBase

Q8TFN2.

Family and domain databases

InterPro

IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.

Pfam

PF00069; Pkinase; 1.
Pfam graphical view of domain structure.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00220; S_TKc; 1.
SMART graphical view of domain structure.

PROSITE

PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Autophagy; Cytoplasm; Kinase; Nucleotide-binding; Protein transport; Serine/threonine-protein kinase; Transferase; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 804`	`804`	`Serine/threonine-protein kinase ATG1.`	`PRO_0000085650`
`DOMAIN`	`12 308`	`297`	`Protein kinase.`
`NP_BIND`	`18 26`	`9`	`ATP (By similarity).`
`ACT_SITE`	`158 158`		`Proton acceptor (By similarity).`
`BINDING`	`41 41`		`ATP (By similarity).`

Sequence information

Length: 804 AA [This is the length of the unprocessed precursor]

Molecular weight: 89844 Da [This is the MW of the unprocessed precursor]

CRC64: 052186AA1F7FC585 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSKHQTQVVG DFTIGPEIGR GSFANVYKGY DNRTKAPVAV KSVFRSRLKN QKLVENLEIE 

        70         80         90        100        110        120 
ISILKNLKNP HIVALLDCVK TDQYFHLFME YCSLGDLSYF IRRRDQLVQT HPLISSILER 

       130        140        150        160        170        180 
YPSPPNSHGL NKVLVVNFLK QLASALEFLR DQNLVHRDIK PQNLLLSPPV HSKEEFKRKG 

       190        200        210        220        230        240 
YSGLWELPVL KIADFGFARF LPSTSMAETL CGSPLYMAPE ILRYEKYNAK ADLWSVGAVI 

       250        260        270        280        290        300 
YEMSVGKPPF RASNHVELLR KIEKSKDEIT FPVSAEVPDD LVRLICGLLK ANPTERMGFQ 

       310        320        330        340        350        360 
EFFNDPLIVY DVQCADEPLE CSNVDEQLFI SEYLPNLKTS PPAKPAPETI KEESEEEERA 

       370        380        390        400        410        420 
ERAPTDSLLI GKEADLRIPR PMEGSGKDEV IKKLINKSSP PPDTVKDGQI KKGARRDKDD 

       430        440        450        460        470        480 
FVYEKDYVVV EKRTVEVNAI ADELAKAGAG AVAIPSPHLG TNEHSAANPS GPTETQTQRR 

       490        500        510        520        530        540 
FSPSSRTSSI GSNRRPSWGD RKMPISISPT NALTKALGYT SNRLFGQQQQ QPQQAQQAAI 

       550        560        570        580        590        600 
ESAITNVTTN LLATKTLRPL KPSQETSLED TEVINQLELL ATMAHAISLF AEVKFSQLIP 

       610        620        630        640        650        660 
LPPSSSSPGS ADYDEMYQND AFPPQMVKSI SSEGVALYVE TLSLLAKAMS IASDWWHQNS 

       670        680        690        700        710        720 
SKPSTSPKLN DLVQWIRSRF NESLEKAEFL RLRLADANEQ LVGESGSSLN KPVVAEKLIF 

       730        740        750        760        770        780 
DRALEMSRTA AMNELKNEDL LGCELSYSTA IWMLEALLSN DEEPVTGNEK LDAEDKKIIE 

       790        800 
LFINSIGNRL KVLRQKIDKQ GVRS

Q8TFN2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools