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UniProtKB/Swiss-Prot entry Q8TF62


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AT8B4_HUMAN
Primary accession number Q8TF62
Secondary accession number Q9H727
Integrated into Swiss-Prot on April 30, 2003
Sequence was last modified on October 14, 2008 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 60)
Name and origin of the protein
Protein name Probable phospholipid-transporting ATPase IM
Synonyms EC 3.6.3.1
ATPase class I type 8B member 4
Gene name
Name: ATP8B4
Synonyms: KIAA1939
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1093/dnares/8.6.319; PubMed=11853319 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Kikuno R., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.";
DNA Res. 8:319-327(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04601; PubMed=16572171 [NCBI, ExPASy, EBI, Israel, Japan]
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
"Analysis of the DNA sequence and duplication history of human chromosome 15.";
Nature 440:671-675(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 907-1192.
TISSUE=Colon;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB075819; BAB85525.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC009753; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC016045; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC025040; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AK025125; BAB15072.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_079113.2; -.
UniGene Hs.511311
3D structure databases
ModBase Q8TF62.
PTM databases
PhosphoSite Q8TF62; -.
Organism-specific databases
HGNC HGNC:13536; ATP8B4.
GenAtlas ATP8B4.
MIM 609123; gene. [NCBI / EBI]
PharmGKB PA25169; -.
GeneCards Q8TF62.
HUGE KIAA1939.
Gene expression databases
ArrayExpress Q8TF62; -.
CleanEx HS_ATP8B4; -.
GermOnline ENSG00000104043; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0015662; Molecular function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from InterPro).
GO:0004012; Molecular function: phospholipid-translocating ATPase activity (inferred from electronic annotation from InterPro).
GO:0015914; Biological process: phospholipid transport (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001757; ATPase_P.
IPR006539; Flippase.
IPR013200; HAD-SF_hydro-like_3.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF08282; Hydrolase_3; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
TIGRFAMs TIGR01652; ATPase-Plipid; 1.
TIGR01494; ATPase_P-type; 4.
PROSITE PS00154; ATPASE_E1_E2; 1.
ProtoNet Q8TF62.
Genome annotation databases
Ensembl ENSG00000104043; Homo sapiens. [Contig view]
GeneID 79895; -.
KEGG hsa:79895; -.
Phylogenomic databases
HOGENOM Q8TF62; -.
HOVERGEN Q8TF62; -.
Other
LinkHub Q8TF62; -.
NextBio 69726; -.
SOURCE ATP8B4; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Hydrolase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1192  1192     Probable phospholipid-transporting ATPase IM. PRO_0000046368
TOPO_DOM   1     44  44     Cytoplasmic (Potential). 
TRANSMEM   45     66  22     Potential. 
TOPO_DOM   67     72  6     Extracellular (Potential). 
TRANSMEM   73     92  20     Potential. 
TOPO_DOM   93    276  184     Cytoplasmic (Potential). 
TRANSMEM   277    298  22     Potential. 
TOPO_DOM   299    327  29     Extracellular (Potential). 
TRANSMEM   328    349  22     Potential. 
TOPO_DOM   350    871  522     Cytoplasmic (Potential). 
TRANSMEM   872    892  21     Potential. 
TOPO_DOM   893    904  12     Extracellular (Potential). 
TRANSMEM   905    924  20     Potential. 
TOPO_DOM   925    954  30     Cytoplasmic (Potential). 
TRANSMEM   955    976  22     Potential. 
TOPO_DOM   977    990  14     Extracellular (Potential). 
TRANSMEM   991   1013  23     Potential. 
TOPO_DOM   1014   1019  6     Cytoplasmic (Potential). 
TRANSMEM   1020   1040  21     Potential. 
TOPO_DOM   1041   1060  20     Extracellular (Potential). 
TRANSMEM   1061   1085  25     Potential. 
TOPO_DOM   1086   1192  107     Cytoplasmic (Potential). 
ACT_SITE   392    392        4-aspartylphosphate intermediate (By similarity). 
METAL   815    815        Magnesium (By similarity). 
METAL   819    819        Magnesium (By similarity). 
VARIANT   225    225  1     N -> S (in dbSNP:rs16963151 [NCBI]). VAR_046962 
VARIANT   452    452  1     H -> N (in dbSNP:rs2452524 [NCBI]). VAR_046963 
VARIANT   1165   1165  1     N -> K (in dbSNP:rs16962989 [NCBI]). VAR_046964 
VARIANT   1190   1190  1     V -> G (in dbSNP:rs16962987 [NCBI]). VAR_046965 
CONFLICT   631    631        G -> E (in Ref. 1; BAB85525). 
Sequence information
Length: 1192 AA [This is the length of the unprocessed precursor] Molecular weight: 135868 Da [This is the MW of the unprocessed precursor] CRC64: FFE8D935B7544D73 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFCSEKKLRE VERIVKANDR EYNEKFQYAD NRIHTSKYNI LTFLPINLFE QFQRVANAYF 

        70         80         90        100        110        120 
LCLLILQLIP EISSLTWFTT IVPLVLVITM TAVKDATDDY FRHKSDNQVN NRQSEVLINS 

       130        140        150        160        170        180 
KLQNEKWMNV KVGDIIKLEN NQFVAADLLL LSSSEPHGLC YVETAELDGE TNLKVRHALS 

       190        200        210        220        230        240 
VTSELGADIS RLAGFDGIVV CEVPNNKLDK FMGILSWKDS KHSLNNEKII LRGCILRNTS 

       250        260        270        280        290        300 
WCFGMVIFAG PDTKLMQNSG KTKFKRTSID RLMNTLVLWI FGFLICLGII LAIGNSIWES 

       310        320        330        340        350        360 
QTGDQFRTFL FWNEGEKSSV FSGFLTFWSY IIILNTVVPI SLYVSVEVIR LGHSYFINWD 

       370        380        390        400        410        420 
RKMYYSRKAI PAVARTTTLN EELGQIEYIF SDKTGTLTQN IMTFKRCSIN GRIYGEVHDD 

       430        440        450        460        470        480 
LDQKTEITQE KEPVDFSVKS QADREFQFFD HHLMESIKMG DPKVHEFLRL LALCHTVMSE 

       490        500        510        520        530        540 
ENSAGELIYQ VQSPDEGALV TAARNFGFIF KSRTPETITI EELGTLVTYQ LLAFLDFNNT 

       550        560        570        580        590        600 
RKRMSVIVRN PEGQIKLYSK GADTILFEKL HPSNEVLLSL TSDHLSEFAG EGLRTLAIAY 

       610        620        630        640        650        660 
RDLDDKYFKE WHKMLEDANA ATEERDERIA GLYEEIERDL MLLGATAVED KLQEGVIETV 

       670        680        690        700        710        720 
TSLSLANIKI WVLTGDKQET AINIGYACNM LTDDMNDVFV IAGNNAVEVR EELRKAKQNL 

       730        740        750        760        770        780 
FGQNRNFSNG HVVCEKKQQL ELDSIVEETI TGDYALIING HSLAHALESD VKNDLLELAC 

       790        800        810        820        830        840 
MCKTVICCRV TPLQKAQVVE LVKKYRNAVT LAIGDGANDV SMIKSAHIGV GISGQEGLQA 

       850        860        870        880        890        900 
VLASDYSFAQ FRYLQRLLLV HGRWSYFRMC KFLCYFFYKN FAFTLVHFWF GFFCGFSAQT 

       910        920        930        940        950        960 
VYDQWFITLF NIVYTSLPVL AMGIFDQDVS DQNSVDCPQL YKPGQLNLLF NKRKFFICVL 

       970        980        990       1000       1010       1020 
HGIYTSLVLF FIPYGAFYNV AGEDGQHIAD YQSFAVTMAT SLVIVVSVQI ALDTSYWTFI 

      1030       1040       1050       1060       1070       1080 
NHVFIWGSIA IYFSILFTMH SNGIFGIFPN QFPFVGNARH SLTQKCIWLV ILLTTVASVM 

      1090       1100       1110       1120       1130       1140 
PVVAFRFLKV DLYPTLSDQI RRWQKAQKKA RPPSSRRPRT RRSSSRRSGY AFAHQEGYGE 

      1150       1160       1170       1180       1190 
LITSGKNMRA KNPPPTSGLE KTHYNSTSWI ENLCKKTTDT VSSFSQDKTV KL 

Q8TF62 in FASTA format

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