ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q8TE23


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name TS1R2_HUMAN
Primary accession number Q8TE23
Secondary accession number Q5TZ19
Integrated into Swiss-Prot on January 4, 2005
Sequence was last modified on October 17, 2006 (Sequence version 2)
Annotations were last modified on    June 10, 2008 (Entry version 57)
Name and origin of the protein
Protein name Taste receptor type 1 member 2 [Precursor]
Synonyms Sweet taste receptor T1R2
G-protein coupled receptor 71
Gene name
Name: TAS1R2
Synonyms: GPR71, T1R2, TR2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT CYS-9.
DOI=10.1073/pnas.072090199; PubMed=11917125 [NCBI, ExPASy, EBI, Israel, Japan]
Li X., Staszewski L., Xu H., Durick K., Zoller M., Adler E.;
"Human receptors for sweet and umami taste.";
Proc. Natl. Acad. Sci. U.S.A. 99:4692-4696(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF458154; AAM12239.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF458149; AAM12239.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF458150; AAM12239.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF458152; AAM12239.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF458153; AAM12239.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF458151; AAM12239.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX537160; CAH69954.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL831755; CAH69954.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL831755; CAI17299.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX537160; CAI17299.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BK000151; DAA00019.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_689418.2; -.
UniGene Hs.553548
3D structure databases
HSSP P23385; 1ISS. [HSSP ENTRY / PDB]
ModBase Q8TE23.
Protein family/group databases
GPCRDB Q8TE23; TS1R2_HUMAN.
Organism-specific databases
H-InvDB HIX0028889; -.
HGNC HGNC:14905; TAS1R2.
GeneLynx TAS1R2; Homo sapiens.
GenAtlas TAS1R2.
MIM 606226; gene. [NCBI / EBI]
PharmGKB PA37919; -.
GeneCards Q8TE23.
Gene expression databases
ArrayExpress Q8TE23; -.
CleanEx HS_TAS1R2; -.
GermOnline ENSG00000179002; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred by curator from UniProtKB).
GO:0046982; Molecular function: protein heterodimerization activity (non-traceable author statement from UniProtKB).
GO:0008527; Molecular function: taste receptor activity (inferred from direct assay from UniProtKB).
GO:0001582; Biological process: detection of chemical stimulus involved in sensory perception of sweet taste (inferred from direct assay from HGNC).
GO:0007186; Biological process: G-protein coupled receptor protein signaling pathway (inferred by curator from HGNC).
QuickGo view.
Family and domain databases
InterPro IPR001828; ANF_lig_bd_rcpt.
IPR000337; GPCR_3.
IPR011500; GPCR_3_NCR.
Graphical view of domain structure.
Pfam PF00003; 7tm_3; 1.
PF01094; ANF_receptor; 1.
PF07562; NCD3G; 1.
Pfam graphical view of domain structure.
PRINTS PR00248; GPCRMGR.
PROSITE PS00979; G_PROTEIN_RECEP_F3_1; FALSE_NEG.
PS00980; G_PROTEIN_RECEP_F3_2; 1.
PS00981; G_PROTEIN_RECEP_F3_3; FALSE_NEG.
PS50259; G_PROTEIN_RECEP_F3_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q8TE23.
Genome annotation databases
Ensembl ENSG00000179002; Homo sapiens. [Contig view]
GeneID 80834; -.
KEGG hsa:80834; -.
NMPDR fig|9606.3.peg.430; -.
Phylogenomic databases
HOGENOM Q8TE23; -.
HOVERGEN Q8TE23; -.
Other
DrugBank DB00168; Aspartame.
SOURCE TAS1R2; Homo sapiens.
GPCRDB-Snakes Q8TE23.
ProtoNet Q8TE23.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Sensory transduction; Signal; Taste; Transducer; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    19  19     Potential. 
CHAIN   20   839  820     Taste receptor type 1 member 2. PRO_0000012957
TOPO_DOM   20   566  547     Extracellular (Potential). 
TRANSMEM   567   587  21     1 (Potential). 
TOPO_DOM   588   602  15     Cytoplasmic (Potential). 
TRANSMEM   603   623  21     2 (Potential). 
TOPO_DOM   624   635  12     Extracellular (Potential). 
TRANSMEM   636   656  21     3 (Potential). 
TOPO_DOM   657   681  25     Cytoplasmic (Potential). 
TRANSMEM   682   702  21     4 (Potential). 
TOPO_DOM   703   727  25     Extracellular (Potential). 
TRANSMEM   728   748  21     5 (Potential). 
TOPO_DOM   749   760  12     Cytoplasmic (Potential). 
TRANSMEM   761   781  21     6 (Potential). 
TOPO_DOM   782   784  3     Extracellular (Potential). 
TRANSMEM   785   805  21     7 (Potential). 
TOPO_DOM   806   839  34     Cytoplasmic (Potential). 
CARBOHYD   84    84        N-linked (GlcNAc...) (Potential). 
CARBOHYD   248   248        N-linked (GlcNAc...) (Potential). 
CARBOHYD   292   292        N-linked (GlcNAc...) (Potential). 
CARBOHYD   312   312        N-linked (GlcNAc...) (Potential). 
CARBOHYD   368   368        N-linked (GlcNAc...) (Potential). 
CARBOHYD   428   428        N-linked (GlcNAc...) (Potential). 
CARBOHYD   487   487        N-linked (GlcNAc...) (Potential). 
CARBOHYD   527   527        N-linked (GlcNAc...) (Potential). 
VARIANT   9     9  1     S -> C (in dbSNP:rs9701796 [NCBI]). VAR_027901 
VARIANT   574   574  1     A -> T (in dbSNP:rs6662276 [NCBI]). VAR_020787 
VARIANT   838   838  1     R -> K (in dbSNP:rs9988418 [NCBI]). VAR_027902 
CONFLICT   191   191        I -> V (in Ref. 1; AAM12239/DAA00019). 
CONFLICT   317   317        R -> G (in Ref. 1; AAM12239/DAA00019). 
CONFLICT   486   486        I -> V (in Ref. 1; AAM12239/DAA00019). 
Sequence information
Length: 839 AA [This is the length of the unprocessed precursor] Molecular weight: 95183 Da [This is the MW of the unprocessed precursor] CRC64: A7F73516489A05F9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGPRAKTISS LFFLLWVLAE PAENSDFYLP GDYLLGGLFS LHANMKGIVH LNFLQVPMCK 

        70         80         90        100        110        120 
EYEVKVIGYN LMQAMRFAVE EINNDSSLLP GVLLGYEIVD VCYISNNVQP VLYFLAHEDN 

       130        140        150        160        170        180 
LLPIQEDYSN YISRVVAVIG PDNSESVMTV ANFLSLFLLP QITYSAISDE LRDKVRFPAL 

       190        200        210        220        230        240 
LRTTPSADHH IEAMVQLMLH FRWNWIIVLV SSDTYGRDNG QLLGERVARR DICIAFQETL 

       250        260        270        280        290        300 
PTLQPNQNMT SEERQRLVTI VDKLQQSTAR VVVVFSPDLT LYHFFNEVLR QNFTGAVWIA 

       310        320        330        340        350        360 
SESWAIDPVL HNLTELRHLG TFLGITIQSV PIPGFSEFRE WGPQAGPPPL SRTSQSYTCN 

       370        380        390        400        410        420 
QECDNCLNAT LSFNTILRLS GERVVYSVYS AVYAVAHALH SLLGCDKSTC TKRVVYPWQL 

       430        440        450        460        470        480 
LEEIWKVNFT LLDHQIFFDP QGDVALHLEI VQWQWDRSQN PFQSVASYYP LQRQLKNIQD 

       490        500        510        520        530        540 
ISWHTINNTI PMSMCSKRCQ SGQKKKPVGI HVCCFECIDC LPGTFLNHTE DEYECQACPN 

       550        560        570        580        590        600 
NEWSYQSETS CFKRQLVFLE WHEAPTIAVA LLAALGFLST LAILVIFWRH FQTPIVRSAG 

       610        620        630        640        650        660 
GPMCFLMLTL LLVAYMVVPV YVGPPKVSTC LCRQALFPLC FTICISCIAV RSFQIVCAFK 

       670        680        690        700        710        720 
MASRFPRAYS YWVRYQGPYV SMAFITVLKM VIVVIGMLAT GLSPTTRTDP DDPKITIVSC 

       730        740        750        760        770        780 
NPNYRNSLLF NTSLDLLLSV VGFSFAYMGK ELPTNYNEAK FITLSMTFYF TSSVSLCTFM 

       790        800        810        820        830 
SAYSGVLVTI VDLLVTVLNL LAISLGYFGP KCYMILFYPE RNTPAYFNSM IQGYTMRRD 

Q8TE23 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!