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[1]
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NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1016/S0006-291X(02)02550-0; PubMed=12419312 [NCBI, ExPASy, EBI, Israel, Japan]
Maruyama T.,
Miyamoto Y.,
Nakamura T.,
Tamai Y.,
Okada H.,
Sugiyama E.,
Nakamura T.,
Itadani H.,
Tanaka K.;
"Identification of membrane-type receptor for bile acids (M-BAR).";
Biochem. Biophys. Res. Commun. 298:714-719(2002).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1074/jbc.M209706200; PubMed=12524422 [NCBI, ExPASy, EBI, Israel, Japan]
Kawamata Y.,
Fujii R.,
Hosoya M.,
Harada M.,
Yoshida H.,
Miwa M.,
Fukusumi S.,
Habata Y.,
Itoh T.,
Shintani Y.,
Hinuma S.,
Fujisawa Y.,
Fujino M.;
"A G protein-coupled receptor responsive to bile acids.";
J. Biol. Chem. 278:9435-9440(2003).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND TISSUE SPECIFICITY.
DOI=10.1016/S0014-5793(02)02775-8; PubMed=12044878 [NCBI, ExPASy, EBI, Israel, Japan]
Takeda S.,
Kadowaki S.,
Haga T.,
Takaesu H.,
Mitaku S.;
"Identification of G protein-coupled receptor genes from the human genome sequence.";
FEBS Lett. 520:97-101(2002).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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- FUNCTION: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.
- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
- TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.
- SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 330 AA [This is the length of the unprocessed precursor] |
Molecular weight: 35248 Da [This is the MW of the unprocessed precursor] |
CRC64: B3A1AEDADEAFE021 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MTPNSTGEVP SPIPKGALGL SLALASLIIT ANLLLALGIA WDRRLRSPPA GCFFLSLLLA
70 80 90 100 110 120
GLLTGLALPT LPGLWNQSRR GYWSCLLVYL APNFSFLSLL ANLLLVHGER YMAVLRPLQP
130 140 150 160 170 180
PGSIRLALLL TWAGPLLFAS LPALGWNHWT PGANCSSQAI FPAPYLYLEV YGLLLPAVGA
190 200 210 220 230 240
AAFLSVRVLA TAHRQLQDIC RLERAVCRDE PSALARALTW RQARAQAGAM LLFGLCWGPY
250 260 270 280 290 300
VATLLLSVLA YEQRPPLGPG TLLSLLSLGS ASAAAVPVAM GLGDQRYTAP WRAAAQRCLQ
310 320 330
GLWGRASRDS PGPSIAYHPS SQSSVDLDLN
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Q8TDU6 in FASTA format |
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ExPASy Home page
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