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UniProtKB/Swiss-Prot entry Q8TDN7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACER1_HUMAN
Primary accession number Q8TDN7
Secondary accession numbers None
Integrated into Swiss-Prot on July 25, 2006
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 38)
Name and origin of the protein
Protein name Alkaline ceramidase 1
Synonyms Alkaline CDase 1
AlkCDase 1
EC 3.5.1.23
N-acylsphingosine amidohydrolase 3
Acylsphingosine deacylase 3
Gene name
Name: ACER1
Synonyms: ASAH3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1074/jbc.M303875200; PubMed=12783875 [NCBI, ExPASy, EBI, Israel, Japan]
Mao C., Xu R., Szulc Z.M., Bielawski J., Becker K.P., Bielawska A., Galadari S.H., Hu W., Obeid L.M.;
"Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides.";
J. Biol. Chem. 278:31184-31191(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
TISSUE SPECIFICITY.
DOI=10.1194/jlr.M600001-JLR200; PubMed=16477081 [NCBI, ExPASy, EBI, Israel, Japan]
Houben E., Holleran W.M., Yaginuma T., Mao C., Obeid L.M., Rogiers V., Takagi Y., Elias P.M., Uchida Y.;
"Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis.";
J. Lipid Res. 47:1063-1070(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF347024; AAL83822.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC112122; AAI12123.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC112124; AAI12125.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00152570; -.
RefSeq NP_597999.1; -.
UniGene Hs.352609
3D structure databases
ModBase Q8TDN7.
Enzyme and pathway databases
BRENDA 3.5.1.23; 247.
Organism-specific databases
GeneCards GC19M006259; -.
HGNC HGNC:18356; ACER1.
GenAtlas ACER1.
PharmGKB PA134897634; -.
Gene expression databases
ArrayExpress Q8TDN7; -.
Bgee Q8TDN7; -.
CleanEx HS_ACER1; -.
GermOnline ENSG00000167769; Homo sapiens.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0000139; Cellular component: Golgi membrane (inferred from electronic annotation from InterPro).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0017040; Molecular function: ceramidase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR008901; APHC.
Graphical view of domain structure.
Pfam PF05875; aPHC; 1.
Pfam graphical view of domain structure.
Genome annotation databases
Ensembl ENSG00000167769; Homo sapiens. [Contig view]
GeneID 125981; -.
KEGG hsa:125981; -.
Phylogenomic databases
HOGENOM Q8TDN7; -.
HOVERGEN Q8TDN7; -.
OMA Q8TDN7; FQYSELV.
Other
NextBio 81606; -.
ProtoNet Q8TDN7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Glycoprotein; Hydrolase; Lipid metabolism; Membrane; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   264  264     Alkaline ceramidase 1. PRO_0000247745
TRANSMEM   28    48  21     Potential. 
TRANSMEM   58    78  21     Potential. 
TRANSMEM   82   102  21     Potential. 
TRANSMEM   120   137  18     Potential. 
TRANSMEM   139   159  21     Potential. 
TRANSMEM   177   197  21     Potential. 
TRANSMEM   207   227  21     Potential. 
CARBOHYD   116   116        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 264 AA [This is the length of the unprocessed precursor] Molecular weight: 31095 Da [This is the MW of the unprocessed precursor] CRC64: E16E5DB81D064F60 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPSIFAYQSS EVDWCESNFQ YSELVAEFYN TFSNIPFFIF GPLMMLLMHP YAQKRSRYIY 

        70         80         90        100        110        120 
VVWVLFMIIG LFSMYFHMTL SFLGQLLDEI AILWLLGSGY SIWMPRCYFP SFLGGNRSQF 

       130        140        150        160        170        180 
IRLVFITTVV STLLSFLRPT VNAYALNSIA LHILYIVCQE YRKTSNKELR HLIEVSVVLW 

       190        200        210        220        230        240 
AVALTSWISD RLLCSFWQRI HFFYLHSIWH VLISITFPYG MVTMALVDAN YEMPGETLKV 

       250        260 
RYWPRDSWPV GLPYVEIRGD DKDC 

Q8TDN7 in FASTA format

View entry in raw text format (no links)
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