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UniProtKB/Swiss-Prot entry Q8TCD6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PHOP2_HUMAN
Primary accession number Q8TCD6
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 41)
Name and origin of the protein
Protein name Pyridoxal phosphate phosphatase PHOSPHO2
Synonym EC 3.1.3.74
Gene name
Name: PHOSPHO2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Bone, and Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
ENZYME ACTIVITY, AND BIOPHYSICOCHEMICAL PROPERTIES.
DOI=10.1016/j.bbapap.2005.06.009; PubMed=16054448 [NCBI, ExPASy, EBI, Israel, Japan]
Roberts S.J., Stewart A.J., Schmid R., Blindauer C.A., Bond S.R., Sadler P.J., Farquharson C.;
"Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2.";
Biochim. Biophys. Acta 1752:73-82(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AC016772; AAY24234.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC022324; AAH22324.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC106013; AAI06014.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001008489.1; -.
UniGene Hs.655150
3D structure databases
ModBase Q8TCD6.
Organism-specific databases
H-InvDB HIX0002574; -.
HGNC HGNC:28316; PHOSPHO2.
GenAtlas PHOSPHO2.
PharmGKB PA134947617; -.
GeneCards Q8TCD6.
Gene expression databases
ArrayExpress Q8TCD6; -.
GermOnline ENSG00000144362; Homo sapiens.
Ontologies
GO
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0033883; Molecular function: pyridoxal phosphatase activity (inferred from electronic annotation from EC).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR006384; HAD-SF_hydro_IB_hyp1.
IPR006383; HAD-SF_hydro_IB_PSP-like.
IPR016965; PyrdxlP_Pase_PHOSPHO2.
Graphical view of domain structure.
Pfam PF06888; Put_Phosphatase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF031051; PyrdxlP_Pase_PHOSPHO2; 1.
TIGRFAMs TIGR01489; DKMTPPase-SF; 1.
TIGR01488; HAD-SF-IB; 1.
ProtoNet Q8TCD6.
Genome annotation databases
Ensembl ENSG00000144362; Homo sapiens. [Contig view]
GeneID 493911; -.
KEGG hsa:493911; -.
Phylogenomic databases
HOVERGEN Q8TCD6; -.
Other
LinkHub Q8TCD6; -.
NextBio 111796; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Hydrolase; Magnesium; Metal-binding; Pyridoxal phosphate.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   241  241     Pyridoxal phosphate phosphatase PHOSPHO2. PRO_0000068833
ACT_SITE   8     8        Nucleophile (By similarity). 
ACT_SITE   10    10        Proton donor (By similarity). 
METAL   8     8        Magnesium (By similarity). 
METAL   10    10        Magnesium (By similarity). 
METAL   179   179        Magnesium (By similarity). 
BINDING   19    19        Substrate (By similarity). 
BINDING   99    99        Substrate (By similarity). 
Sequence information
Length: 241 AA [This is the length of the unprocessed precursor] Molecular weight: 27769 Da [This is the MW of the unprocessed precursor] CRC64: C9F0447F2A1A5FFA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKILLVFDFD NTIIDDNSDT WIVQCAPNKK LPIELRDSYR KGFWTEFMGR VFKYLGDKGV 

        70         80         90        100        110        120 
REHEMKRAVT SLPFTPGMVE LFNFIRKNKD KFDCIIISDS NSVFIDWVLE AASFHDIFDK 

       130        140        150        160        170        180 
VFTNPAAFNS NGHLTVENYH THSCNRCPKN LCKKVVLIEF VDKQLQQGVN YTQIVYIGDG 

       190        200        210        220        230        240 
GNDVCPVTFL KNDDVAMPRK GYTLQKTLSR MSQNLEPMEY SVVVWSSGVD IISHLQFLIK 


D 

Q8TCD6 in FASTA format

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