NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=GB-M1;
DOI=10.1038/35106579; PubMed=11719806 [NCBI, ExPASy, EBI, Israel, Japan]
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.;
"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi.";
Nature 414:450-453(2001).

Comments

CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
PATHWAY: Pyrimidine metabolism; dTTP biosynthesis .
SIMILARITY: Belongs to the thymidylate synthase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AL590448; CAD26314.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_597138.1; -.

3D structure databases

HSSP

P04818; 1HW3. [HSSP ENTRY / PDB]

ModBase

Q8SRG2.

Ontologies

GO:0004799;	Molecular function: thymidylate synthase activity (inferred from electronic annotation from InterPro).
GO:0006231;	Biological process: dTMP biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000398; Thymidylat_synth_C.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.572.10; Thymidylat_synth_C; 1.

PANTHER

PTHR11549:SF2; Thymidylat_synth_C; 1.

Pfam

PF00303; Thymidylat_synt; 1.
Pfam graphical view of domain structure.

PRINTS

PR00108; THYMDSNTHASE.

ProDom

PD001180; Thymidylat_synth; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR03284; thym_sym; 1.

PROSITE

PS00091; THYMIDYLATE_SYNTHASE; 1.

ProtoNet

Q8SRG2.

Genome annotation databases

GeneID

859560; -.

GenomeReviews

AL590448_GR; ECU08_0090.

KEGG

ecu:ECU08_0090; -.

NMPDR

fig|6035.1.peg.1028; -.

Phylogenomic databases

HOGENOM

Q8SRG2; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Methyltransferase; Nucleotide biosynthesis; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 294`	`294`	`Thymidylate synthase 3.`	`PRO_0000140907`
`ACT_SITE`	`174 174`		`By similarity.`

Sequence information

Length: 294 AA [This is the length of the unprocessed precursor]

Molecular weight: 33098 Da [This is the MW of the unprocessed precursor]

CRC64: B2521707E86C157E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPQDPRHPEH QYLDLVKHIL ENGARRMDRT GTGTLSVFGA TMRFSLEDNT FPLLTTRRVF 

        70         80         90        100        110        120 
YRGVVEELLF FLRGETDSKV LEKKGVRIWE KNGAKQFLQS VGIDREEGDL GPIYGFQWRH 

       130        140        150        160        170        180 
FGARYETSAS SYEGKGVDQI ASAIAAIRAN PASRRIVVSA WNPTDLGSMA LPPCHVLFQF 

       190        200        210        220        230        240 
NVTDGKLSCA MYQRSGDMGL GVPFNIASYS LLTILVAHLT GLQPGEFVHF LGDAHVYLDH 

       250        260        270        280        290 
VDSLRQQVQR PPRAFPKLFV SPKGPRTEPE HFQYEDFELV GYDPHPAIKM NMSA

Q8SRG2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools