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- FUNCTION: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events (By similarity).
- CATALYTIC ACTIVITY: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
- SUBUNIT: Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Binds LRP1B; binding is followed by internalization and degradation (By similarity).
- SUBCELLULAR LOCATION: Secreted, extracellular space (By similarity).
- DOMAIN: Both FN1 and one of the kringle domains are required for binding to fibrin (By similarity).
- DOMAIN: Both FN1 and EGF-like domains are important for binding to LRP1 (By similarity).
- DOMAIN: The FN1 domain mediates binding to annexin A2 (By similarity).
- DOMAIN: The second kringle domain is implicated in binding to cytokeratin-8 and to the endothelial cell surface binding site (By similarity).
- PTM: The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa (By similarity).
- SIMILARITY: Belongs to the peptidase S1 family [view classification].
- SIMILARITY: Contains 1 EGF-like domain.
- SIMILARITY: Contains 1 fibronectin type-I domain.
- SIMILARITY: Contains 2 kringle domains.
- SIMILARITY: Contains 1 peptidase S1 domain [view classification].
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 562 AA [This is the length of the unprocessed precursor] |
Molecular weight: 63668 Da [This is the MW of the unprocessed precursor] |
CRC64: F9E6B4C77CB101E8 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MYALKRELWC VLLLCGAICT SPSQETHRRL RRGVRSYRVT CRDEKTQMIY QQHQSWLRPL
70 80 90 100 110 120
LRGNRVEHCW CNDGQTQCHS VPVKSCSEPR CFNGGTCLQA IYFSDFVCQC PVGFIGRQCE
130 140 150 160 170 180
IDARATCYED QGITYRGTWS TTESGAECVN WNTSGLASMP YNGRRPDAVK LGLGNHNYCR
190 200 210 220 230 240
NPDKDSKPWC YIFKAEKYSP DFCSTPACTK EKEECYTGKG LDYRGTRSLT MSGAFCLPWN
250 260 270 280 290 300
SLVLMGKIYT AWNSNAQTLG LGKHNYCRNP DGDTQPWCHV LKDHKLTWEY CDLPQCVTCG
310 320 330 340 350 360
LRQYKEPQFR IKGGLYADIT SHPWQAAIFV KNRRSPGERF LCGGILISSC WVLSAAHCFQ
370 380 390 400 410 420
ERFPPHHVRV VLGRTYRLVP GEEEQAFEVE KYIVHKEFDD DTYDNDIALL QLKSDSLTCA
430 440 450 460 470 480
QESDAVRTVC LPEANLQLPD WTECELSGYG KHEASSPFYS ERLKEAHVRL YPSSRCTSKH
490 500 510 520 530 540
LFNKTITNNM LCAGDTRSGG DNANLHDACQ GDSGGPLVCM KGNHMTLVGV ISWGLGCGQK
550 560
DVPGVYTKVT NYLNWIRDNT RP
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Q8SQ23 in FASTA format |
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