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UniProtKB/Swiss-Prot entry Q8SPQ7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FMO3_MACMU
Primary accession number Q8SPQ7
Secondary accession numbers None
Integrated into Swiss-Prot on February 12, 2003
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name Dimethylaniline monooxygenase [N-oxide-forming] 3
Synonyms EC 1.14.13.8
Hepatic flavin-containing monooxygenase 3
FMO 3
Dimethylaniline oxidase 3
Gene name
Name: FMO3
From
Macaca mulatta (Rhesus macaque) [TaxID: 9544] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=11717182 [NCBI, ExPASy, EBI, Israel, Japan]
Cashman J.R., Zhang J., Leushner J., Braun A.;
"Population distribution of human flavin-containing monooxygenase form 3: gene polymorphisms.";
Drug Metab. Dispos. 29:1629-1637(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY063498; AAL86612.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001028065.1; -.
UniGene Mmu.3639
3D structure databases
ModBase Q8SPQ7.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0031227; Cellular component: intrinsic to endoplasmic reticulum membrane (inferred from electronic annotation from InterPro).
GO:0005792; Cellular component: microsome (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0004499; Molecular function: flavin-containing monooxygenase activity (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR012143; dManiline_mOase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000960; Flavin_mOase.
IPR002255; Flavin_mOase_3.
Graphical view of domain structure.
Pfam PF00743; FMO-like; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000332; FMO; 1.
PRINTS PR00368; FADPNR.
PR00370; FMOXYGENASE.
PR01123; FMOXYGENASE3.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
ProtoNet Q8SPQ7.
Genome annotation databases
Ensembl ENSMMUG00000007952; Macaca mulatta. [Contig view]
GeneID 574244; -.
KEGG mcc:574244; -.
Phylogenomic databases
HOVERGEN Q8SPQ7; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; FAD; Flavoprotein; Membrane; Microsome; Monooxygenase; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   532  531     Dimethylaniline monooxygenase [N-oxide-forming] 3. PRO_0000147655
NP_BIND   9    14  6     FAD (Potential). 
NP_BIND   191   196  6     NADP (Potential). 
Sequence information
Length: 532 AA [This is the length of the unprocessed precursor] Molecular weight: 60152 Da [This is the MW of the unprocessed precursor] CRC64: 73A4D13EE2A24A72 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGKKVAIIGA GVSGLASIRS CLEEGLEPTC FEKSNDIGGL WKFSDHAEEG RASIYKSVFT 

        70         80         90        100        110        120 
NSSKEMMCFP DFPYPDDFPN FMHNSKIQEY LTAFAKEKSL LKYIQFKTFV SSVNKRPDFA 

       130        140        150        160        170        180 
TTGQWDVTTE RDGKRESAVF DAVMVCSGHH VYPNLPKESF PGLNHFKGKC FHSRDYKEPG 

       190        200        210        220        230        240 
VFKGKRVLVV GLGNSGCDIA TELSHTAEQV VISSRSGSWV MSRVWDNGYP WDMVLITRFG 

       250        260        270        280        290        300 
TFLKNNLPTA ISDWLYMKQM NARFKHENYG LMPLNGVLRK EPVFNDELPA CILCGIVSVK 

       310        320        330        340        350        360 
PNVKKFTETS AIFEDGTTFE GIDCVIFATG YSYTYTFLDE SIIKNRNNEI ILFKGVFPPL 

       370        380        390        400        410        420 
LEKSTIAVIG FVQSLGAAIP TVDLQSRWAA RVIKGTCTLP SMEDMMNDIN EKMERKHKWY 

       430        440        450        460        470        480 
GKSETLQTDY IVYMDELSSF IGVKPNIPWL FLTDPKLAME VYFGPCSPYQ FRLVGPGKWP 

       490        500        510        520        530 
GARNAILTQW DRSLKPLQTR VVGRLQKPCF FFHWLKPFAI PILLIAVFLG LT
Q8SPQ7 in FASTA format

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