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UniProtKB/Swiss-Prot entry Q8RY89


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PI5K8_ARATH
Primary accession number Q8RY89
Secondary accession number Q9C962
Integrated into Swiss-Prot on October 25, 2005
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 41)
Name and origin of the protein
Protein name Phosphatidylinositol-4-phosphate 5-kinase 8
Synonyms AtPIP5K8
EC 2.7.1.68
1-phosphatidylinositol-4-phosphate kinase 8
PtdIns(4)P-5-kinase 8
Diphosphoinositide kinase 8
Gene name
Name: PIP5K8
OrderedLocusNames: At1g60890
ORFNames: T7P1.4
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/35048500; PubMed=11130712 [NCBI, ExPASy, EBI, Israel, Japan]
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
Nature 408:816-820(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
[3]
GENE FAMILY, AND NOMENCLATURE.
DOI=10.1104/pp.004770; PubMed=12226484 [NCBI, ExPASy, EBI, Israel, Japan]
Mueller-Roeber B., Pical C.;
"Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C.";
Plant Physiol. 130:22-46(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AC018908; AAG51639.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY074507; AAL69491.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY133824; AAM91758.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D96634; D96634.
RefSeq NP_176286.2; -.
UniGene At.28792
3D structure databases
HSSP P78356; 1BO1. [HSSP ENTRY / PDB]
ModBase Q8RY89.
Organism-specific databases
TAIR At1g60890; -.
Gene expression databases
ArrayExpress Q8RY89; -.
GermOnline AT1G60890; Arabidopsis thaliana.
Ontologies
GO
GO:0005886; Cellular component: plasma membrane (inferred from direct assay from TAIR).
GO:0016308; Molecular function: 1-phosphatidylinositol-4-phosphate 5-kinase activity (inferred from electronic annotation from EC).
GO:0046488; Biological process: phosphatidylinositol metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR003409; MORN.
IPR002498; PIP5K_core.
IPR016034; PIP5K_core_sub.
IPR017163; PIP5K_pln_prd.
Graphical view of domain structure.
PANTHER PTHR23086; PIP5K; 1.
Pfam PF02493; MORN; 8.
PF01504; PIP5K; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF037274; PIP5K_plant_prd; 1.
SMART SM00698; MORN; 8.
SM00330; PIPKc; 1.
SMART graphical view of domain structure.
ProtoNet Q8RY89.
Genome annotation databases
GeneID 842381; -.
GenomeReviews CT485782_GR; AT1G60890.
KEGG ath:AT1G60890; -.
NMPDR fig|3702.1.peg.5471; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Kinase; Repeat; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   769  769     Phosphatidylinositol-4-phosphate 5-kinase 8. PRO_0000185480
REPEAT   16    38  23     MORN 1. 
REPEAT   39    61  23     MORN 2. 
REPEAT   62    84  23     MORN 3. 
REPEAT   85   107  23     MORN 4. 
REPEAT   108   130  23     MORN 5. 
REPEAT   131   153  23     MORN 6. 
REPEAT   154   176  23     MORN 7. 
REPEAT   177   198  22     MORN 8. 
DOMAIN   428   765  338     PI5K. 
REGION   725   746  22     Activation loop (By similarity). 
Sequence information
Length: 769 AA [This is the length of the unprocessed precursor] Molecular weight: 87403 Da [This is the MW of the unprocessed precursor] CRC64: 2E8A045211FB39A3 [This is a checksum on the sequence]
        10         20         30         40         50         60 
METRPAERVF SNGDVYSGQL KGTLPHGKGK YAWPDGIIYE GDWEEGKISG RGKLMWSSGA 

        70         80         90        100        110        120 
KYEGDFSGGY LHGFGTLTSP DGSVYAGAWR MNVRHGLGRK EYCNSDVYDG SWREGLQDGS 

       130        140        150        160        170        180 
GSYSWYNGNR FIGNWKKGKM SGRGVMSWAN GDLFNGFWLN GLRHGSGVYK YADGGFYFGT 

       190        200        210        220        230        240 
WSRGLKDGSG VFYPAGSKHP SLKKWHRHFG YDDTGNFLLS HNSTINIDDL RTSKAVSRSL 

       250        260        270        280        290        300 
SELTTTSGLT RTSERYPDDY WSTSDPPRDF MHHGPSSKSA RSVDSGQSEI RDKNPIVFER 

       310        320        330        340        350        360 
EYMQGVLIKE RIMSSIDMSH RARPLNLTKE VTVSACVSFL GGKWNHYLML NLQLGIRYTV 

       370        380        390        400        410        420 
GKITPVPPRE VRASDFSERA RIMMFFPRNG SQYTPPHKSI DFDWKDYCPM VFRNLREMFK 

       430        440        450        460        470        480 
LDAADYMMSI CGDDGLREIS SPGKSGSIFY LSHDDRFVIK TLKRSELKVL LRMLPRYYEH 

       490        500        510        520        530        540 
VGDYENTLIT KFFGVHRIKL KWGKKVRFVV MGNMFCTELK IHRRYDLKGS TQGRYTEKNK 

       550        560        570        580        590        600 
IGEKTTLKDL DLAYEFHMDK LLREALFKQI ILDCSFLESL QILDYSLLLG LHFRAPDPLT 

       610        620        630        640        650        660 
DILEPPNEMS DQESDSVGSV DVNLPREPSI PPKGLLMVTH EPNSVNTAPG PHIRGSTLRA 

       670        680        690        700        710        720 
FSVGEKEVDL ILPGTARLRV QLGVNMPAQA HHKLGQDNEE SGTVELFEVY DVVVYMGIID 

       730        740        750        760 
ILQEYNMKKK VEHTCKSMKY DPMTISAIEP TLYSKRFIDF LLKVFPEKA 

Q8RY89 in FASTA format

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